نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 کارشناس ارشد، دانشکدة تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران

2 دانشیار ، دانشکدة تربیت بدنی و علوم ورزشی دانشگاه شهید بهشتی، تهران، ایران

3 دانشیار، پژوهشکدة غدد درون ریزی و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران 4

4 استادیار، دانشکدة تربیت بدنی و علوم ورزشی، دانشگاه علامه طباطبائی، تهران، ایران

چکیده

هدف از تحقیق حاضر بررسی تأثیر تمرین استقامتی و مصرف ویتامین E بر غلظت آدیپونکتین و شاخص مقاومت انسولین بود. به این منظور 30 زن سالم غیرفعال (سن 7/3±8/24 سال، وزن 3/1± 3/60 کیلوگرم، قد 3/1±9/161سانتی‌متر) به سه گروه ورزش و ویتامین E (VE)، ویتامین E (V) و کنترل (C) تقسیم شدند. آزمودنی‌های گروه ورزش و ویتامین سه بار در هفته با شدت 65 تا 80 درصد حداکثر ضربان قلب تمرین کردند و مکمل ویتامین E را به مدت چهار هفته روزی IU 400 همراه با ناهار مصرف کردند. آزمودنی­های گروه ویتامین E هیچ‌گونه فعالیت ورزشی نداشتند. آنالیز آماری داده‌ها نشان داد که غلظت آدیپونکتین در هر سه گروه کاهش معنا­دار (05/0P<) مشابهی نشان داد، با این­ حال، بین سه گروه تفاوت معنا­داری (05/0P>) مشاهده نشد. مقایسۀ درون‌گروهی و بین­گروهی برای غلظت انسولین و همچنین شاخص مقاومت انسولین در سه گروه تفاوت معنا­داری نشان نداد (05/0P>). اگرچه غلظت گلوکز در سه گروه کاهش معنا­داری داشت، بین سه گروه تفاوت معنا­داری یافت نشد. بنابراین می­توان نتیجه گرفت که ترکیب تمرین استقامتی و مصرف ویتامین E در کوتاه‌مدت تأثیری بر غلظت آدیپونکتین و شاخص مقاومت انسولین زنان سالم ندارد.

کلیدواژه‌ها

عنوان مقاله [English]

The Interactive Effect of Endurance Training and Vitamin E Intake on Adiponectin and Insulin Resistance Index Levels in Inactive Women

نویسندگان [English]

  • Zeinab Hosseinzadeh 1
  • Sajad Ahmadizad 2
  • Mehdi Hedayati 3
  • Minoo Bassami 4
  • Hosna Rashidi 1

چکیده [English]

The aim of this study was to investigate the interactive effect of endurance training and vitamin E intake on adiponectin concentration and insulin resistance index. 30 healthy inactive women (age, 24.8±3.7 years, weight, 60.3±1.3 kg, height, 161.9±1.3 cm) were divided into three groups including vitamin E and exercise (VE), vitamin E (V) and control (C). Subjects in VE group performed a training protocol 3 times per week at the intensity of 65 to 80% of maximal heart rate and daily consumed 400 IU vitamin E at lunch for 4 weeks. Subjects in V group did not perform any exercise training. Data analysis revealed that adiponectin concentration significantly reduced similarly in all three groups (P<0.05); however, no significant differences were found among the groups (P>0.05). Intra-group and intergroup comparisons for insulin concentration and insulin resistance index showed no significant differences in all groups (P>0.05). Although glucose concentration reduced significantly in all three groups, no significant differences were found among them.Therefore, it could be concluded that short-term combination of endurance training and vitamin E consumption does not influence adiponectin concentration and insulin resistance index in healthy women.

کلیدواژه‌ها [English]

  • Adipokine
  • aerobic exercise
  • insulin
  • vitamin E
1. شیدفر فرزاد، رضایی خدیجه؛ حسینی، شریعه؛ حیدری، ایرج. ( 1387 ). اثر ویتامین مقاومت به انسولین و عوامل خطرساز بیماری های قلبی - عروقی در افراد مبتلا به سندرم متابولیک.454-مجلة غدد درو نریز و متابولیسم ایران، سال دهم، ش 5، ص445

2. Ahmadizad, S. and Mahmoud, S. (2006). Responses of platelet activation and function to
a single bout of resistance exercise and recovery. Clinical Hemorheol and Microcircul.,
35:159-168.
3. Ahmadizad, S., Haghighi, A.H. and Hamedinia, M.R. (2007). Effects of resistance versus
endurance training on serum adiponectin and insulin resistance index. Eur J of
Endocrinol., 157 625-631.
4. Andersson, A., Sjodin, A, Olsson, R. and Vessby, B. (1998). Effects of physical exercise
on phospholipid fatty acid composition in skeletal muscle. American J of Physiology.,
274: E432-E438.
5. Brigelius-Flohe, R. and Traber, M. (1999). Vitamin E: function and metabolism. Faseb J.,
13: 1145-1155.
6. Dela, F., Handberg, A., Mikines, K.J., Vinten, J. and Galbo, H. (1993). GLUT4 and
insulin receptor binding and kinase activity in trained human muscle. J of Physiol., 469:
615-624.
7. Dela, F., Ploug, T., Handberg, A., Petersen, L.N., Larsen, J.J., Mikines, K.J. and Galbo,
H. (1994). Physical training increases muscle GLUT4 protein and mRNA in patients with
NIDDM. Diabetes., 43: 862-865.
8. Ebeling, P., Bourey, R., Koranyi, L., Tuominen, J.A., Groop, L.C., Henriksson, J., and et
al. (1993). Mechanism of enhanced insulin sensitivity in athletes: increased blood flow,
muscle glucose transport protein (Glut4) concentration, and glycogen synthase activity. J
of Clin Invest., 92:1623-1631.
9. Erin, E., Kersha, W. and Jeffrey S. (2004). Adipose tissue as an endocrine organ. J of Clin
Endocrin Metab., 89(6): 2548-2556.
10. Esposito, K., Pontillo, A., Di palo, C. and et al. (2003). Effect of weight loss and lifestyle
changes on vascular inflammatory markers in obese women: a randomized trial. JAMA.,
289:1799-1804.
11. Frank, L.L., Sorensen, B.E., Yasui, Y. and Shelley, S. (2005). Effects of exercise on
metabolic risk variables in overweight postmenopausal women: a randomized clinical
trial. Obes Res., 13: 615-625.
12. Goldstein, B.J. and Scalia, R. (2004). Adiponectin: a novel adipokine linking adipocytes
and vascular function. J of Clin Endocrinol Metab., 89(6):2563-2568.
13. Hickey, M.S., Pories, W.J., MacDonald, K.G., Cory, K.A., Dohm, G.L, Swanson, M.S,
and et al. (1998). A new paradigm for type 2 diabetes mellitus: could it be a disease of the
foregut? Ann Surg., 227: 637-644.
14. Holst, D., Grimaldi, P.A. (2002). New factors in the regulation of adipose differentiation
and metabolism. Curr Opin Lipidol., 13:241-245.
15. Houstis, N., Rosen E.D. and Lander E.S. (2006). Reactive oxygen species have a causal
role in multiple forms of insulin resistance. Nature., 440:944-948.
16. Ivy, J.I., Zderic, T.W. and Fogt, D.L. (1992). Prevention and treatment of noninsulin
dependent diabetes mellitus. Exer Sport Sci Rev, 27: 1-35.
17. Joseph, A., Amiot, Landrier, J., Gouranton, E., Yazidi, C.E., Malezet, C.h., Balaguer, P.
and Borel, P. (2009). Proliferator-Activated Receptor {gamma}-Dependent Mechanism
Adiponectin Expression Is Induced by Vitamin E via a Peroxisome. Endocrinol.,
150:5318-5325.
18. Kraemer, W.J., Ratamess, N.A. and French, D.N. (2002). Resistance training for health
and performance. Curr Sports Med Rep., 1(3):165-171.
19. Kriketos, A.D., Gan, S.K.H., Poynten, A.M. and Furler, S.M. (2004). Exercise
increases adiponectin levels and insulin sensitivity in humans. Diabetes Care., 27 (2):
629-630.
20. Marcell, T.J., Mcauley, K.A., Traustadottir, T. and Reaven, P.D. (2005). Exercise
training is not associated with improved levels of C-reactive protein or adiponectin.
Metabol., 54(4): 533-541.
21. Matsuzawa, Y., Funahashi, T., Kihara, S. and Shimomura, I. (2004). Adiponectin and
Metabolic Syndrome. Thromb Vasc Biol., 24: 29-33.
22. Matthews, D.R., Hosker, A.S., Rudenski, B.A., and et al. (1985). Homeostasis model
assessment: Insulin resistance and b-cell function from fasting plasma glucose and insulin
concentrations in man. Diabetol., 28: 412-419.
23. Monzillo, I.U., Hamdy, O., Horton, E.S., Ledbury, S., Mullooly, C., Jarema, C., and et al.
(2003). Effect of lifestyle modification on adipokine levels in obese subjects with insulin
resistance. Obes Res., 11(9):1048-1054.
24. Naglaa, F.A., Nasr Arafat, B., Enas, M.K. and Mona Maher, A. (2010). Effect of Exercise
Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High
Fat Diet. American J of Biochem Biotechnol., 6(2): 77-83.
25. Oberbach, A., Tonjes, A., Kloting, N. and et al. (2006). Effect of a 4 week physical
training program on plasma concentrations of inflammatory markers in patients with
abnormal glucose tolerance. Eur J of Endocrinol., 154:577-585.
26. Ouchi, N., kihara, S., Arita, Y. and et al. (2000). Adiponectin, an adipocyte-derived
plasma protein, inhibits endothelial nf-kappab signaling through a camp-dependent
pathway. Circulation., 102:1296-1301.
27. Ouchi, N., kihara, S., Arita, Y. and et al. (1999). Novel modulator for endothelial
adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation.,
100:2473-2476.
28. Paolisso, G., Di Maro, G., Galzerano, D., Cacciapuoti, F., Varricchio, G., Varricchio, M.
and et al. (1994). Pharmacological doses of vitamin E and insulin action in elderly
subjects. Am J Clin Nutr., 59: 1291-1296.
29. Ring-Dimitriou, S., Paulweber, B., von Duvillard, S.P., Stadlmann, M., LeMura L.M.,
Lang, J. and Muller, E. (2006). The effect of physical activity and physical fitness on
plasma adiponectin in adults with predisposition to metabolic syndrome. Eur J Appl
Physiol., 98(5):472-481.
30. Ryan, A.S., Berman, D., Nicklas, B.J., Sinha, M., Gingerich, R., Meneilly, G.S., and et al.
(2003 ). Plasma adiponectin and leptin levels, body composition, and glucose utilization
in adult women with wide ranges of age and obesity.Diabetes Care.,. 26 (8): 2383-2388.
31. Shen, X.H., Tang, Q.Y., Huang, J. and Cai, W. (2010). Vitamin e regulates adipocytokine
expression in a rat model of dietary-induced obesity. Exper Biol Med.,235: 47-51. -
32. Shojaee-Moradie, F., Baynes, K. C.R., Pentecost, C., Bell, J. D., Thomas, E.L., Jackson,
N. C.,. and et al. (2007). Exercise training reduces fatty acid availability and improves the
insulin sensitivity of glucose metabolism. Diabetologia., 50:404-413.
33. Tarquini, R., lazzeri, C. and Gemini, G.F. (2007). Adiponectin and the cardiovascular
system: from risk to disease. Intern Emerg Med., 2:165-176.
34. Vaccarino, V., Bremner, D. (2005). Stress Response and the Metabolic Syndrome.
Cardiology., 11 (2): 1-11.
35. Wayne, H., Sutherland, F., Patrick, J., Robert, J., Sylvia, A. and Anne, R. (2007). Vitamin
e supplementation and plasma 8-isoprostane and adiponectin in overweight subjects.
Obesity., 15: 286-391.
36. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R.E. and
Tataranni, P.A. (2001). Hypoadiponectinemia in obesity and type 2 diabetes: close
association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab.,
86(5):1930-1935.
37. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., and et al. (2003).
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature.,
423(6941):762-769.
38. Yanovski, J., Yanovski, S. (1999). Recent advances in basic obesity research. Biochem
Biophys Res Commun., 257(1):79-83.
39. Yokoyama, H., Emoto, M., Araki, T., Fujiwara, S., Motoyama, K., Morioka, T., and et al.
(2004). Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in
type 2 diabetes. Diabetes Care., 27:1756-1758