تأثیر تمرین تناوبی با شدت بالا بر مقادیر سرمی عامل رشد فیبروبلاست 21، مقاومت به انسولین و پروفایل لیپیدی در زنان چاق غیرفعال

نوع مقاله: مقاله پژوهشی

نویسندگان

1 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

3 کارشناسی ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

چکیده

عامل رشد فیبروبلاست 21 (FGF21) از هورمون‌های متابولیسمی بدن است که از بافت‌های مختلف ترشح می‌شود و در متابولیسم کربوهیدرات و لیپید نقش دارد و به بهبود همئوستاز گلوکز، پارامترهای چربی و کاهش وزن منجر می‌شود. بنابراین، هدف پژوهش حاضر بررسی تأثیر هشت هفته تمرین تناوبی با شدت بالا (HIIT) بر مقادیر سرمی FGF21، پروفایل لیپیدی و مقاومت به انسولین زنان چاق غیرفعال بود. 20 زن چاق غیرفعال (میانگین سن 96/2 ± 15/30 سال و BMI 27/1 ± 34/30 Kg/m2) به‌طور تصادفی در دو گروه 10 نفری HIIT و کنترل، داوطلب شرکت در پژوهش حاضر شدند. برنامۀ تمرین HIIT به مدت هشت هفته، سه جلسه در هفته و با شدت 90 درصد ضربان قلب هدف اجرا شد. داده‌های پژوهش با استفاده از آزمون آماریt  همبسته وt  مستقل در سطح معناداری 05/0P< تجزیه‌وتحلیل شدند. نتایج تحلیل آماری نشان داد برنامۀ تمرین HIIT به‌طور معناداری مقادیر سرمی FGF21 و HDL-Cزنان چاق غیرفعال را افزایش (05/0P<) و به‌طور معناداری مقاومت به انسولین، گلوکز، انسولین، کلسترول تام، تری‌گلیسیرید، CO/HDLرا کاهش داد. همچنین، نتایج آزمونt  مستقل نشان داد بین تمرین HIIT و کنترل در مقادیر FGF21 و گلوکز تفاوت معناداری وجود دارد (05/0P<).براساس نتایج پژوهش حاضر، به‌نظر می‌رسد تمرین HIIT با افزایش مقادیر  FGF21ممکن است نقش مؤثری در همئوستاز گلوکز، کاهش تودۀ چربی و افزایش مصرف انرژی داشته باشد و برای پیشگیری از چاقی و بهبود شاخص مقاومت به انسولین مورد توجه قرار گیرد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of High Intensity Interval Training on Serum Levels of FGF21, Insulin Resistance and Lipid Profile in Sedentary Obese Women

نویسندگان [English]

  • javad toloueiazar 1
  • Asghar Tofighi 2
  • rogayhe alizadeh 3
1 Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2 Associate Professor of exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
3 M.Sc. of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
چکیده [English]

Fibroblast growth factor 21 (FGF21) is one of the metabolism hormones which is secreted from different tissues, plays a role in carbohydrate and lipid metabolism and improves glucose hemostasis, fat parameters and weight loss. Thus, the aim of this study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on serum levels of FGF21, lipid profile and insulin resistance in sedentary obese women. 20 sedentary obese women (mean age 30.15±2.96 years and BMI 30.34±1.27 Kg/m2) volunteered to participate in the study and were randomly assigned to HIIT and control groups (each group 10 subjects). HIIT program was conducted for 8 weeks, 3 sessions each week with 90% target heart rate. The research data were analyzed by independent and dependent t tests at P<0.05. The results of the statistical analysis showed that HIIT program significantly increased serum levels of FGF21 and HLD-C (P<0.05) and significantly decreased insulin resistance, glucose, insulin, total cholesterol, triglyceride and CO/HDL in sedentary obese women. Also, the results of independent t test showed a significant difference between HIIT and control groups in FGF21 and glucose levels (P<0.05). According to the results of this study, it seems that high intensity interval training (HIIT) may play an influential role in glucose hemostasis, decreasing fat mass, and increasing energy expenditure through an increase in FGF21 levels and therefore may be considered to prevent obesity and improve  insulin resistance marker.

کلیدواژه‌ها [English]

  • FGF21
  • high intensity interval training
  • insulin resistance
  • lipid profile
  • sedentary obese women
1. Calvani R, Leeuwenburgh C, Marzetti E. Brown adipose tissue and the cold war against obesity. Diabetes. 2014;63(12):3998-4000.

2. Plinta R, Olszanecka-Glinianowicz M, Drosdzol-Cop A, Chudek J, Skrzypulec-Plinta V. The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players. Journal of endocrinological investigation. 2012;35(6):595-601.

3. Slusher A, Whitehurst M, Zoeller R, Mock J, Maharaj M, Huang C-J. Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals. Nutrition, Metabolism and Cardiovascular Diseases. 2015;25(9):839-45.

4. Sypniewska G. Laboratory assessment of cardiometabolic risk in overweight and obese children. Clinical biochemistry. 2015;48(6):370-6.

5. Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, et al. Interplay between FGF21 and insulin action in the liver regulates metabolism. The Journal of clinical investigation. 2014;124(2):515-27.

6. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes care. 2012;35(6):1364-79.

7. Kim KH, Lee M-S. FGF21 as a stress hormone: the roles of FGF21 in stress adaptation and the treatment of metabolic diseases. Diabetes & metabolism journal. 2014;38(4):245-51.

8. Bottcher RT, Niehrs C. Fibroblast growth factor signaling during early vertebrate development. Endocrine reviews. 2004;26(1):63-77.

9. Kim KH, Lee M-S. FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs. Journal of Endocrinology. 2015;226(1):R1-R16.

10. Cuevas-Ramos D, Almeda-Valdes P, Gómez-Pérez FJ, Meza-Arana CE, Cruz-Bautista I, Arellano-Campos O, et al. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. European journal of endocrinology. 2010;163(3):469-77.

11. Liu J, Xu Y, Hu Y, Wang G. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism. 2015;64(3):380-90.

12. Taniguchi H, Tanisawa K, Sun X, Cao Z-B, Oshima S, Ise R, et al. Cardiorespiratory fitness and visceral fat are key determinants of serum fibroblast growth factor 21 concentration in Japanese men. The Journal of Clinical Endocrinology & Metabolism. 2014;99(10):E1877-E84.

13. Kim KH, Kim SH, Min Y-K, Yang H-M, Lee J-B, Lee M-S. Acute exercise induces FGF21 expression in mice and in healthy humans. PloS one. 2013;8(5):e63517.

14. Farzanegi P. The effect of aerobic training on levels of FGF21 in diabetic woman. 2014.

15. Azuma K, Osawa Y, Tabata S, Katsukawa F, Ishida H, Oguma Y, et al. Decrease in regional body fat after long-term high-intensity interval training. The Journal of Physical Fitness and Sports Medicine. 2017;6(2):103-10.

16. Avazpor S, Kalkhoran J, Amini HA. The Comparison of the Effects of Two Types of High Intensity Interval Training (HIIT) on Body Mass and Physiological Indexes in Inactive Female Students. J Sports Sci.2016;219:4-25.

17. Connolly LJ, Nordsborg NB, Nyberg M, Weihe P, Krustrup P, Mohr M. Low-volume high-intensity swim training is superior to high-volume low-intensity training in relation to insulin sensitivity and glucose control in inactive middle-aged women. European journal of applied physiology. 2016;116(10):1889-97.

18. Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes care.2002;25(10):1729-36.

19. Organization WH. Global recommendations on physical activity for health. 2010.

20. Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women. Medicine and science in sports and exercise. 1980; 12 (3):175-81.

21. Siahkouhian M, Azizan S, Roohi BN. A new approach for the determination of anaerobic threshold: methodological survey on the modified Dmax method. 2012.

22. Gurd BJ, Perry CG, Heigenhauser GJ, Spriet LL, Bonen A. High-intensity interval training increases SIRT1 activity in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism. 2010;35(3):350-7.

23. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.

24. Jung TW, Yoo HJ, Choi KM. Implication of hepatokines in metabolic disorders and cardiovascular diseases. BBA clinical. 2016;5:108-13.

25. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. Journal of applied physiology. 2007.

26. Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, et al. Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. Physiological reports. 2016;4(12):e12828.

27. Cuevas-Ramos D, Almeda-Valdés P, Meza-Arana CE, Brito-Córdova G, Gómez-Pérez FJ, Mehta R, et al. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PloS one. 2012;7(5):e38022.

28. Abbasi DA, Hedayatzadeh S, Abdi A, Abbaszadeh SH. The effect of 8 weeks of aerobic exercise on serum levels of FGF21, apolipoprotein A-1and LDL-c to HDL-C ratio in obese women. 2016.

29. Kong Z, Sun S, Liu M, Shi Q. Short-term high-intensity interval training on body composition and blood glucose in overweight and obese young women. Journal of diabetes research. 2016;2016.

30. Birjandi SC, Saghebjoo M, Hedayati M. Effect of high intensity interval training and L-Arginine supplementation on serum levels of fibroblast growth factor 21 and atrial natriuretic peptide in overweight and obese young men. Journal Of Birjand University Of Medical Sciences. 2016; 23 (3):211-21.

31. Hu FB, Li TY, Colditz GA, Willett WC, Manson JE. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. Jama. 2003;289(14):1785-91.

32. Marquis-Gravel G, Hayami D, Juneau M, Nigam A, Guilbeault V, Latour É, et al. Intensive lifestyle intervention including high-intensity interval training program improves insulin resistance and fasting plasma glucose in obese patients. Preventive medicine reports. 2015;2:314-8.

33. Oberlin DJ, Smith J, Ritsche K, Wideman L. High intensity interval training in healthy males does not improve markers of insulin sensitivity. Journal of Sports Science. 2015;3(2):49-56.

34. Camporez JPG, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, et al. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology. 2013;154(9):3099-109.

35. Elmer DJ, Laird RH, Barberio MD, Pascoe DD. Inflammatory, lipid, and body composition responses to interval training or moderate aerobic training. European journal of applied physiology. 2016;116(3):601-9.

36. Petersen BA, Hastings B, Gottschall JS. High intensity interval cycling improves physical fitness in terainedadults. Journal of Fitness Research. 2016;5(1).

37. Mohamadhasani F, Esfandyarinezhad A. Effect of two training on orexin A and lipid profile in obese adolescent boys. Bulletin de la Societe Royale des Sciences de Liege. 2016;85:653-7.

38. Vainionpää A, Korpelainen R, Kaikkonen H, Knip M, LeppÄluoto J, Jämsä T. Effect of impact exercise on physical performance and cardiovascular risk factors. Medicine and science in sports and exercise. 2007;39(5):756-63.

39. Paahoo A,  Tadibi V, Behpoor N. (2015). “The effect of 12 weeks high intensity interval training (HIIT) on testosterone, cortisol and lipid profile levels in obese and overweight boys.” Metabolism and Exercise A bioannual journal. VOL. 5.NO(1) PP:46-58.(In persian).