نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
نویسندگان
1 گروه فیزیولوژی ورزشی، دانشکدة علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
2 نویسنده مسؤول، گروه فیزیولوژی ورزشی، دانشکدة علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
3 گروه تربیت بدنی و علوم ورزشی، دانشکدة علوم انسانی، دانشگاه کاشان، کاشان، ایران.
4 گروه اطفال، دانشکدة پزشکی، بیمارستان بوعلی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.
چکیده
مقدمه: شواهد زیادی مبنی بر اثر مکمل‌یاری عصارۀ شاتوت و تمرینات ورزشی بر شاخص‌های التهابی مؤثر در پاتوژنز دیابت در سالمندان وجود ندارد. هدف از تحقیق حاضر، بررسی اثر 8 هفته تمرینات ترکیبی (هوازی + مقاومتی) و مصرف عصارۀ برگ شاتوت بر سطوح سرمی لیپوکالین 2، اینترلوکین 1 بتا و شاخص‌های متابولیکی مرتبط با دیابت در بیماران سالمند مبتلا به دیابت نوع دو بود.
روش پژوهش: در این پژوهش نیمه‌تجربی و یک‌سوکور، 40 نفر از مردان سالمند با محدودۀ سنی 67.07±7.48 سال به‌صورت هدفمند به‌عنوان نمونه انتخاب شدند و به‌طور تصادفی، در پنج گروه مساوی (تمرین، مکمل، مکمل+تمرین، دارونما و کنترل)، قرار گرفتند. دوز روزانه 1000 میلی‌گرم (دو عدد کپسول 500 میلی‌گرمی) عصارۀ برگ شاتوت در 3 نوبت، به مدت 2 ماه استفاده شد. گروه‌ها به مدت 8 هفته و هر هفته 3 جلسه به مدت 90 دقیقه به تمرین پرداختند. متغیرهای مورد بررسی 24 ساعت پیش و 48 ساعت پس از دورۀ مداخلـه اندازه‌گیری شدند.
یافته‌ها: مقدار لیپوکالین 2، اینترلوکین 1 بتا و مقاومت به انسولین در پس‌آزمون گروه تمرین، تمرین+مکمل و مکمل نسبت به پیش‌آزمون کاهش معناداری داشت (P<0.05). در تغییرات بین‌گروهی، مقدار لیپوکالین 2، اینترلوکین 1 بتا و مقاومت به انسولین در گروه تمرین، تمرین+مکمل و مکمل نسبت به گروه دارونما و کنترل کاهش معناداری داشت (P<0.05).
نتیجه‌گیری: به‌نظر می‌رسد مصرف عصارۀ شاتوت می‌تواند تأثیرگذاری تمرین ورزشی را در کاهش نشانگرهای التهابی مؤثر در دیابت افزایش دهد و به‌همراه تمرین ترکیبی تأثیر هم‌افزایی داشته باشد.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The Effect of Mulberry leaf Extract Supplementation and Combined Exercises on Lipocalin-2, Interleukin 1 beta Levels and Diabetes-Related Metabolic Parameters in Elderly Patients With Type 2 Diabetes
نویسندگان [English]
- Mohammad Ebrahim Bahram 1
- Roghayeh Afroundeh 2
- MohammadJavad Pourvaghar 3
- Farnaz Seify 1
- Leila Katebi 4
1 Department of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
2 Corresponding Author, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
3 Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
4 Department of Pediatrics, School of Medicine Bu'ali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
چکیده [English]
Introduction: There is not much evidence about the complementary effect of Mulberry extract and exercise on the inflammatory indicators that are effective in the pathogenesis of diabetes in the elderly. This study aimed to investigate the effect of 8 weeks of combined exercise (aerobic+ resistance) and consumption of Mulberry leaf extract on serum levels of lipocalin-2, interleukin-1 beta, and metabolic parameters related to diabetes in elderly patients with type 2 diabetes.
Methods: In this quasi-experimental and single-blind study, 40 elderly with an age range of 67.07±7.48 years were purposefully selected as a sample and randomly assigned into five equal groups (Exercise, Supplement, Supplement + Exercise, Placebo, and Control). A daily dose of 1000 mg (two 500 mg capsules) of Mulberry leaf extract was used three times weekly for two months. The groups practiced three 90 minutes sessions per week for eight weeks. The studied variables were measured 24 hours before and 48 hours after the intervention period.
Results: The levels of lipocalin-2, interleukin-1 beta, and insulin resistance in the post-test of Exercise, Supplement + Exercise, and Supplement groups were significantly reduced compared to the pre-test (P<0.05). In the inter-group changes, the level of lipocalin-2, interleukin-1 beta, and insulin resistance in the Exercise, Supplement + Exercise, and Supplement groups had a significant decrease compared to the Placebo and Control groups (P<0.05).
Conclusion: It seems that the consumption of Mulberry extract can increase the effectiveness of exercise in reducing the inflammatory markers effective in diabetes and have a synergistic effect along with combined exercise.
کلیدواژه‌ها [English]
- Combined Exercises
- Lipocalin 2
- Interleukin 1 Beta
- Mulberry Leaf Extract
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