نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
نویسندگان
1 دانشجوی دکتری، گروه فیزیولوژی ورزشی ، واحد کرمانشاه ، دانشگاه آزاد اسلامی ، کرمانشاه ، ایران
2 استادیار، گروه فیزیولوژی ورزشی ، واحد کرمانشاه ، دانشگاه آزاد اسلامی ، کرمانشاه ، ایران (نویسنده مسئول)
3 استادیار، گروه حرکات اصلاحی ، واحد کرمانشاه ، دانشگاه آزاد اسلامی ، کرمانشاه ، ایران
4 دانشیار، گروه جراحی عروق و تروما ، واحد توسعه تحقیقات بالینی ، بیمارستان امام رضا (ع) ، دانشگاه علوم پزشکی کرمانشاه ، کرمانشاه ، ایران
چکیده
هدف از پژوهش حاضر مقایسة تأثیر شش ماه برنامة ترکیبی مراقبتی با مکمل‌دهی سیر بر برخی عوامل انعقادی در مردان میانسال مبتلا به DVT بود. تحقیق حاضر از نوع نیمه‌تجربی و با طرح کارآزمایی بالینی (کد: IRCT20210718051924N1) انجام گرفت. آزمودنی‌ها 40مرد (سن 01/4±50/51 سال، درصد چربی 24/3±63/28 درصد) با سابقة حداقل 3 سال ابتلا به DVT بودند که از داروی وارفارین استفاده می‌کردند و به‌صورت تصادفی در چهار گروه 1. تمرین‌ترکیبی، 2. تمرین‌ترکیبی+مکمل سیر، 3. مکمل سیر و 4. کنترل تقسیم شدند. تمرین ترکیبی به مدت 24 هفته با تواتر 3 جلسه در هفته که ابتدا تمرین مقاومتی (با شدت 50 – 60 درصد 1RM) و سپس تمرین هوازی (با شدت 55 تا 60 درصد ضربان قلب ذخیره) انجام گرفت. مکمل سیر روزانه 1200میلی‌گرم به‌صورت کپسول هر روز ساعت 10صبح استفاده شد. فاکتورهای PT، PTT و INR پیش و پس از 24 هفته اندازه‌گیری شد. از آزمون تحلیل واریانس دوطرفه، آزمون tزوجی (به‌منظور بررسی تفاوت درون‌گروهی) و آزمون تعقیبی توکی (به‌منظور بررسی تفاوت بین‌گروهی) در سطح معناداری (05/0P<) استفاده شد. یافته‌ها نشان داد هم تمرین ترکیبی+سیر و هم مصرف سیر به‌تنهایی بر میزان PT (سیر 3/3 درصد افزایش 004/0P=؛ تمرین+مکمل 3/13 درصد افزایش 001/0P=) و INR (سیر 2 درصد افزایش 013/0P=؛ تمرین+مکمل 46 درصد افزایش 001/0P=) تأثیر معناداری داشتند. همچنین تمرین ترکیبی+سیر بر میزان PTT5/1 درصد افزایش (014/0P=) تأثیر معناداری داشت. اما این میزان تأثیرات در گروه تمرینات ترکیبی (PT: 355/0P=، INR:259/0P=، PTT:448/0P=) و گروه سیر در میزان PTT (504/0p=) معنادار نبود. همچنین 24 هفته تمرین ترکیبی توأم با مصرف سیر بیشترین میزان افزایش PT و INR را نسبت به سایر گروه‌ها در پی داشت (PT: نسبت به مکمل سیر 004/0P=، نسبت به تمرین ترکیبی 004/0P=، INR: نسبت به مکمل سیر 001/0P=، نسبت به تمرین ترکیبی 004/0P=). توصیه می‌شود از تمرینات ترکیبی توأم با مصرف سیر به‌دلیل تأثیر بر فاکتورهای PT و INR و نقش مهم این فاکتورها در برقراری تعادل مجدد هموستاز استفاده شود.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The effect of a six-month combined care program with garlic supplementation on coagulation factors in middle-aged men with deep vein thrombosis
نویسندگان [English]
- Hamed Saed 1
- Sedigheh Hosseinpour Delavar 2
- Hassan Safikhani 3
- Mohammadreza Sobhiyeh 4
1 1. PhD student ، Department of Exercise physiology ، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran
2 Assistant Professor، Department of Exercise Physiology، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran (Corresponding Author)
3 Assistant Professor، Department of Corrective Exercises ، Kermanshah Branch ، Islamic Azad University ، Kermanshah ، Iran
4 Associate Professor , Department of Vascular & Endovascular Surgery, Clinical Research Development Center, Imam Reza Hospital، Kermanshah University of Medical Sciences ، Kermanshah , Iran
چکیده [English]
The purpose of this study was to compare the effect of six-months of combined care program with garlic supplementation on coagulation factors (INR, PPT, PT) in middle-aged men with DVT. The present study was a quasi-experimental with a clinical trial design (code: IRCT20210718051924N1). Subjects were 40 men (age: 51.50 ±4.01 years, fat percentage: 28.63 ±3.24) with a history of at-least 3 years of DVT who were taking warfarin randomly divided into four groups: Combined-exercise, Combined-exercise +garlic, Garlic and Control. Combined-exercise for 24 weeks, 3 sessions per-week, first resistance training (50 to 60% 1RM) and then aerobic training (55 to 60% of the reserve-heart-rate). 1200mg daily garlic supplement was used in the form of capsules at ten o'clock in the morning. PT, PTT and INR factors were measured before and after 24 weeks. Two-way analysis of variance, paired t-test and Tukey post-hoc test were used (P<0.05). The results showed that both combined-exercise +garlic and consumption of garlic increased the PT (garlic 3.3%, p=0.004; exercise +supplement 13.3%, P=0.001) and INR (garlic 2%, p=0.013; exercise +supplement 46%, p=0.001) had a significant effect, also combined-exercise +garlic on the PTT 1.5% (p=0.014) had a significantly effect. But this wasn’t of effects in the combined-exercises (PT: p=0.355, INR: p=0.259, PTT: p=0.448) and the group Garlic was-not significant in PTT (p=0.504). It is recommended to use combined exercises with garlic consumption because of its effect on PT and INR and the important role of these factors in rebalancing homeostasis.
کلیدواژه‌ها [English]
- Combined Exercise
- Deep Vein Thrombosis (DVT)
- Coagulation Factors
- Garlic Supplement
Copyright © 2021
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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