تأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) و استقامتی بر میزان قند خون و محتوای پروتئین فولیستاتین در بافت بطن چپ قلب موش‌های صحرایی نر مبتلا به دیابت نوع 1

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکدة علوم ورزشی، دانشگاه شمال، آمل، ایران

2 استادیار گروه فیزیولوژی ورزشی، دانشکدة علوم ورزشی، دانشگاه شمال، آمل، ایران

چکیده

فولیستاتین یک پروتئین کلیدی در تنظیم هیپرتروفی عضلانی (قلبی و اسکلتی) است که بیماری دیابتی نوع 1 می‌تواند به نقص در عملکرد آن منجر شود. بنابراین، هدف از تحقیق حاضر، بررسی تأثیر 6 هفته تمرین تناوبی با شدت بالا (HIIT) و استقامتی بر میزان قند خون و محتوای پروتئین فولیستاتین در بافت بطن چپ قلب موش‌های صحرایی نر مبتلا به دیابت نوع 1 است. در این تحقیق، 18 سر موش صحرایی نر 2 ماهه نر از نژاد اسپراگ‌داولی با میانگین وزن 20±300 گرم انتخاب شدند. پس از دیابتی شدن نوع 1 از طریق محلول استرپتوزوتوسین، به روش تصادفی به 3 گروه: 1. تمرین HIIT 2. تمرین استقامتی و 3. کنترل (هر گروه 6 سر) تقسیم شدند. گروه‌های تمرینی 4 روز در هفته مطابق با برنامه‌های تمرینی HIIT و استقامتی به مدت 6 هفته به تمرین ورزشی پرداختند. برای تجزیه‌وتحلیل داده‌ها از آزمون آنوای-یکطرفه و آزمون تعقیبی توکی استفاده شد. 6 هفته تمرین HIIT و استقامتی به کاهش معنا‌دار میزان قند خون (0001/0=P) و افزایش معنا‌دار محتوای پروتئین فولیستاتین (0001/0=P) نسبت به گروه کنترل منجر شد. تمرین HIIT و استقامتی، سطوح قند خون را کاهش داد که نشان‌دهندة این مطلب است، که این دو نوع تمرینی می‌تواند راه درمانی مناسب و غیرتهاجمی برای کنترل دیابت باشد. همچنین تمرین استقامتی و تمرین HIIT به افزایش محتوای درون سلولی پروتئین فولیستاتین منجر شد که این افزایش در گروه استقامتی بیشتر بوده است که می‌تواند جهت هیپرتروفی فیزیولوژیک و کاهش عوارض پاتولوژیک قلبی از جمله کاردیومیوپاتی دیابتی مفید باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of six weeks of high-intensity interval training (HIIT) and endurance on blood glucose and Follistatin protein content in the left ventricular tissue of the heart of male rats with type 1 diabetes

نویسندگان [English]

  • Hajar Khanjani 1
  • Mohammedreza Esmaelzadeh Toloee 2
1 Master of Exercise Physiology, Sport Sciences Faculty, Shomal University, Amol, Iran
2 Assistant Professor. Department of Exercise Physiology, Sport Sciences Faculty, Shomal University, Amol, Iran.
چکیده [English]

Follistatin is a key protein in the regulation of muscles (heart and Skeletal) hypertrophy that type 1 diabetes can lead to dysfunction. Therefore, the aim of the present study was to investigate the effect of six weeks of high-intensity interval training (HIIT) and endurance on blood glucose and Follistatin protein content in the left ventricular tissue of the heart of male rats with type 1 diabetes. In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 300±20 g were selected. After becoming type 1 diabetic through streptozotocin solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 6 weeks according to HIIT and endurance training programs. One-way ANOVA and Tukey post hoc test were used to analyze the data. Six weeks of HIIT and endurance training resulted in a significant decrease in blood glucose levels (p=0.0001) and a significant increase in Follistatin protein content (p=0.0001) compared to the control group. HIIT and endurance training lowered blood glucose levels, indicating that these two types of training could be appropriate and non-invasive treatment for control diabetes. Also, endurance training and HIIT training increased the intracellular content of Follistatin protein, which can be useful for physiological hypertrophy and reduction of cardiac pathological complications, including diabetic cardiomyopathy.

کلیدواژه‌ها [English]

  • Blood Glucose
  • diabetes
  • Endurance training
  • Follistatin. Heart
  • high-intensity interval training
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