تأثیر هشت هفته تمرین مقاومتی بر مقادیر سرمی IL-15، IL-6، TNF-α و مقاومت به انسولین در مردان سالمند دیابتی نوع 22

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران.

3 دکتری فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، گیلان، ایران.

چکیده

هدف از پژوهش حاضر بررسی تأثیر 8 هفته تمرین مقاومتی بر مقادیر سرمی IL-15، IL-6 ، TNF-α و مقاومت به انسولین در مردان سالمند دیابتی نوع 2 بود. بدین‌منظور، 20 مرد سالمند مبتلا به دیابت نوع 2 (سن 97/4±45/72 سال، وزن 57/12±70/79 کیلوگرم، BMI 07/91±4/27 کیلوگرم) انتخاب شدند و به‌طور تصادفی در دو گروه تمرین مقامتی (10 نفر) و کنترل (10 نفر) قرار گرفتند. گروه تمرین مقاومتی به مدت 8 هفته، 3 جلسه در هر هفته، 8 حرکت را 3 ست با 10 تکرار با 70 درصد 1RM اجرا کردند. از آزمون ANCOVA و T همبسته برای تحلیل داده‌ها استفاده و سطح معنا‌داری 05/0 درنظر گرفته شد. در حالت پایه و 48 ساعت پس از آخرین جلسۀ تمرینی نمونه‌های خون جمع‌آوری و مقادیر سرمی IL-15، IL-6، TNF-α، انسولین، گلوکز به روش الایزا اندازه‌گیری شد. نتایج تحلیل آماری نشان داد که 8 هفته تمرین مقاومتی به‌طور معناداری مقادیر سرمی IL-15 را افزایش و مقادیر انسولین، گلوکز و مقاومت به انسولین را کاهش داد. با این حال، تأثیر معناداری بر مقادیر سرمی IL-6 و TNF-α نداشت. براساس نتایج پژوهش حاضر، به‌نظر می‌رسد که تمرین مقاومتی می‌تواند با افزایش مقادیرIL-15 به بهبود مقاومت به انسولین در مردان سالمند دیابتی نوع 2 منجر شود.

کلیدواژه‌ها


عنوان مقاله [English]

The effects of eight weeks of resistance training on serum levels IL-15, IL-6, TNF-α and insulin resistance in older type 2 diabetic men

نویسندگان [English]

  • javad tolouei azar 1
  • fatemeh shabkhiz 2
  • mousa khalafi 3
1 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2 Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran. Tehran. Iran
3 PhD of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Guilan, Iran
چکیده [English]

The aim of this study is to investigate the effects of eight weeks of resistance training on serum levels of IL-15, IL-6, TNF-α and insulin resistance in elderly men with type 2 diabetes. For this purpose, twenty elderly man with type 2 diabetes (age: 72.45 ± 4.97, weight: 79.77 ± 12.57, BMI: 27.91 ± 4.7) were randomly assigned to two groups of resistance training (n =10) and control (n = 10). Resistance Training was performed for eight weeks for 3 sessions/wk, 8 main movement including 3 sets with 10 repetitions at 70% 1RM. The paired t test and ANCOVA were used to analyze data in the significance level of 0.05. Blood samples were collected at baseline and 48 hours following the last training session. Serum levels of IL-15, IL-6, TNF-α, insulin and glucose were measured by ELISA method. The results of data analysis showed that eight weeks of resistance training led to an increase in serum levels of IL-15 and a decrease in serum levels of insulin, glucose and insulin resistance. However, it had no significant effect on serum levels of IL-6 and TNF-α. Based on the results of this study, it seems that resistance training may lead to improved insulin resistance in elderly men with type 2 diabetes by increasing the circulating levels of IL-15

کلیدواژه‌ها [English]

  • resistance training
  • Inflammatory myokine
  • Aging
  • type 2 diabetes
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