نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 دانشجوی دکتری،گروه تربیت بدنی و علوم ورزشی دانشکده ادبیات ،علوم انسانی و اجتماعی،دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران

2 دکتری فیزیولوژی ورزش، استادیار گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات، علوم انسانی و اجتماعی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران

3 ،دانشیار و هیات علمی دانشکده تربیت بدنی ،دانشگاه آزاد اسلامی واحد تهران مرکز، تهران، ایران

4 دکترای فیزیولوژی ورزش ،استادیار و هیات علمی گروه تربیت بدنی و علوم ورزشی ، دانشکده ادبیات ،علوم انسانی و اجتماعی،دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران

چکیده

استفادة مفید از داروها مثل متادون همراه با تمرینات ورزشی می‌تواند سطح سلامتی را بهبود بخشد. هدف از این مطالعه، مقایسة اثر تمرینات متفاوت همراه با مصرف متادون بر فیبرینوژن و نیمرخ لیپیدی مردان معتاد بود. بدین‌منظور 90 مرد معتاد (3 /4 ±8/36 سال) تحت درمان در زندان به‌صورت تصادفی به شش گروه 15 نفره تقسیم شدند: کنترل، معتادان گمنام یا NA، تمرین هوازی+متادون، تمرین هوازی+کاهش متادون، تمرین مقاومتی+متادون، تمرین مقاومتی+کاهش متادون. گروه‌های تجربی تمرین را به مدت 12 هفته و 3 جلسه در هفته اجرا کردند. تمرین هوازی شامل 4 تا 8 ست 3 دقیقه‌ای با 90-80 درصد ضربان قلب بیشینه روی دوچرخة کارسنج بود. تمرین مقاومتی با 12 تکرار و 3 ست 70 تا 85 درصد یک تکرار بیشینه بود. دادها با نرم‌افزار SPSS و تحلیل واریانس چندگانه (MANOVA) و آزمون تعقیبی توکی در سطح معنا‌داری (05/0P≤) تحلیل شدند. یافته‌ها نشان داد میزان لیپوپروتیین پرچگال (HDL) خون در گروه‌های تمرین نسبت به گروه کنترل با افزایش معنا‌دار (0001/0P≤) همراه بود. همچنین سطوح لیپوپروتیین کم‌چگال )005/0P≤)، تری‌گلیسرید (008/0P≤)، کلسترول تام (014/0 P≤) و فیبرینوژن (0001/0P≤)در گروه‌های تمرینی نسبت به گروه کنترل با کاهش معنا‌داری همراه بود. همچنین تأثیر تمرین هوازی نسبت به تمرین مقاومتی در تمامی متغیرهای اندازه‌گیری‌شده بیشتر بود.نتایج نشان داد تمرین ورزشی منظم به‌ویژه از نوع هوازی و مقاومتی همراه با کاهش مصرف متادون تأثیر مطلوبی بر عوامل التهابی و در نهایت سلامتی و تندرستی افراد معتاد دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Aerobic and Resistance Training with Different dose of Methadone on Fibrinogen and Lipid Profile in Addicted Men

نویسندگان [English]

  • Rasoul Chegol 1
  • Mandana gholami 2
  • Hasan Matin Homaee 3
  • Hosein Abednatanzi 4
  • Farshad Ghazalian 4

1 Ph.D. Student, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran

2 . Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences,

3 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Tehran Central Branch, Tehran, Iran

4 Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran

چکیده [English]

Background and Aim: Effective use of medications as methadone with exercise training can facilitate the development of healthy. The aim of this study was to compare the effect of different training with methadone on fibrinogen and lipid profile of addicted men.
Methodology: 90 addicted men are treated in prison (36.8 ± 4.3yrs) were randomly divided into six groups (n=15): control, Narcotics Anonymous(NA), aerobic training + methadone, aerobic training + methadone reduction, resistance training + methadone, Resistance training + methadone reduction. Experimental groups performed training for 12 weeks, three sessions in week. Aerobic training consisted of 4 to 8 sets, 3-min at 80–90 % maximum heart rate (HRmax) on a cycle ergometer. Resistance training performed with 8 to 12 repetitions, 3 sets and 70-85% one repetition maximum(1RM). Data were analyzed by SPSS software and Multiple analysis of variance (MANOVA) and Tukey post hoc test at the significant level (P≤0.05).
Results: The high-density lipoproteins (HDL) level of blood in the training groups was significantly increased (P≤00001) compared to the control group. Also, low-density lipoproteins (LDL, P≤0.005), Triglycerides (TG, P≤0/008), Total Cholesterol (P≤0/014 and fibrinogen (P≤00001) levels were significantly reduced in the training groups compared to the control group. Also, the aerobic training groups had a greater effect of all the measured variables than the resistance training.
Conclusion: regular exercise, especially aerobic and resistance exercises with a reduction in methadone has a favorable effect on inflammatory factors and ultimately the health of addicted people

کلیدواژه‌ها [English]

  • Aerobic and Resistance training"
  • " Fibrinogen"
  • " Lipid profile "
  • " Methadone
  • "Withdrawal addiction
1.   Bonakdaran S, Akbari Rad M, Hasanzadeh Deloie M, Akhoondpoor manteghi M, Firoozi A. QTc Prolongation in Methadone Users and Its Relation with Hormonal Changes. Medical Journal of Mashhad University of Medical Sciences. 2017;60(2):441-9.
2.   Feizi Manesh B, Yarahmadi Y. A Survey of the Effect of Methadone Maintenance Treatment (MMT) on Cognitive Functions of Opioid-dependent Patients in Central prison of Hamedan. Middle Eastern Journal of Disability Studies. 2017;7(0):16-.
3.   Vestal-Laborde A, Eschenroeder A, Bigbee J, Robinson S, Sato-Bigbee C. The Opioid System and Brain Development: Effects of Methadone on the Oligodendrocyte Lineage and the Early Stages of Myelination. Developmental Neuroscience. 2014;36.
4.   Aghili M, Moloodi M, Afshar H, Salehi M, Hasanzadeh A, Adibi P. Prevalence of Gastrointestinal Symptoms in Opioid Consumers Referring to Methadone Maintenance Treatment (MMT) Clinics in Isfahan, Iran. Journal of Isfahan Medical School. 2013;31:843-50.
5.   Khalili M, Ghosian MH, Niknam A. Study and Comparison of the Effect of Oral Administration of Peganum Harmala Seeds and Methadone on Morphine Withdrawal Syndrome in Rats. Pathobiology Research. 2010;13(1):37-46.
6.   Greeneltch K, Kelly-Welch A, Shi Y, Keegan A. Chronic Morphine Treatment Promotes Specific Th2 Cytokine Production by Murine T Cells In Vitro via a Fas/Fas Ligand-Dependent Mechanism. Journal of immunology (Baltimore, Md : 1950). 2005;175:4999-5005.
7.   Loui monfared A, Mami S, Salati AP. The Effect of the Opium Addiction on Histological Structure of Liver and Kidney in Rabbits. Journal of Ilam University of Medical Sciences. 2013;21(3):39-45.
8.   Donges C, Duffield R, Drinkwater E. Effects of Resistance or Aerobic Exercise Training on Interleukin-6, C-Reactive Protein, and Body Composition. Medicine and Science in Sports and Exercise. 2010;42:304-13.
9.   Timmons B, Bar-Or O. Growth-Related Changes in the Acute Immune Response to Exercise in Healthy Boys. Medicina Sportiva. 2008;12:92-8.
10. Khademi A, Tofighi A, Tolouei azar J, Saify Nabiabad H, Nouri Habashi A. Modulation of Blood Hemostasis by Concurrent Training in Obese Women with Low-mobility. Studies in Medical Sciences. 2019;29(11):781-92.
11. barzegari H, Choobineh S, akbarnejad a, rahimzadeh h. The Effect of Endurance Training on Some Inflammatory Markers in Male Smokers. Sport Physiology & Management Investigations. 2018;10(2):21-30.
12. Somkuwar SS, Staples MC, Fannon MJ, Ghofranian A, Mandyam CD. Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior. Brain Plast. 2015;1(1):63-81.
13. Zou L, Pan Z, Yeung A, Talwar S, Wang C, Liu Y, et al. A Review Study on the Beneficial Effects of Baduanjin. The Journal of Alternative and Complementary Medicine. 2018;24(4):324-35.
14. Pouladi S, Bagherpour Borazjani A, Motamed N, Amini A, Rahbar A, Vahedparast H, et al. A Survey on the Effect of Psyllium on Serum Levels of Triglycerid and Lipoproteins. Iranian South Medical Journal. 2009;11(2):139-46.
15. SAREMI A. Sporting Exercies and Diabetes Mellitus Type 2: a Review on Evidences. Journal of Cell and Tissue. 2011;2(3):-.
16. Najafipour H, Joukar S, Malekpour-Afshar R, Mirzaeipour F, Nasri HR. Passive Opium Smoking Does not have Beneficial Effect on Plasma Lipids and Cardiovascular Indices in Hypercholesterolemic Rabbits with Ischemic and Non-ischemic Hearts. J Ethnopharmacol. 2010;127(2):257-63.
17. Abbasi Moghdam M, Keshvari M, Tahramuzi MA. The Effect of 8 Weeks Aerobic Training on Changes Beta-endorphin, Cortisol, Growth Hormone Levels and Anthropometric Factors in Recovering Addicts. Medical Journal of Tabriz Univercity of Medical Science. 2019;40(60 #T00182):-.
18. Fathi M, Mir E. The Effect of 12 Resistance Training Sessions on Some Coagultion and Fibrinolytic Factors In Non-active Men. Journal Of PracticalL Studies at Biosciences in Sport. 2015;3(5):-.
19. Vakili J, Hosseinpour L. The Effect of 8 Weeks Aerobic Exercise Traning along with Green Tea Consumption on the Cardiovascular Risk in Obese Women. Journal of Practical Studies at Biosciences in Sport. 2015;3(5):-.
20. Nash MS, Jacobs PL, Mendez AJ, Goldberg RB. Circuit Resistance Training Improves the Atherogenic Lipid Profiles of Persons with Chronic Paraplegia. The Journal of Spinal Cord Medicine. 2001;24(1):2-9.
21. Mirzaeipour F, Azdaki N, Mohammadi G, Oshaghi E. The Effects of Opium Addiction through Different Administration Routes on Inflammatory and Coagulation Factors. Journal of Kerman University of Medical Sciences. 2013;20:292-300.
22. Moloudi A, Sabzi F, Shahhosaini E. Analysis of Coagulation Tests, Proteins C and S, and Plasma Fibrinogen in Addicts and Non-addicts with Coronary Artery Disease. Journal of Kermanshah University of Medical Sciences. 2014;17(12):e74287.
23. Maesomi M, Nasri HR, Farajpour F. Comparison of Plasma Fibrinogen Level in Opium Addict Men with Non-addict men. Journal of Kerman University of Medical Sciences. 2001;8(1):27-31.
24. Dehghan S, Sharifi GR, Faramarzi M. The Effect of Eight Week Low Impact Rhythmic Aerobic Training on Total Plasma Homocysteine Concentration in Older Non-athlete Women. Journal of Mazandaran University of Medical Sciences. 2009;19(72):53-9.
25. Saremi A, Khalaji H, Momeni S. Effect of Resistance Training on Serum Level of C-Reactive Protein (CRP) and Fibrinogen in Male Addicts. Research on Addiction. 2016; 9(36):111-24.
26. Kamath S, Lip GY. Fibrinogen: Biochemistry, Epidemiology and Determinants. QJM: An International Journal of Medicine. 2003;96(10):711-29.
27. Ghanei AM, Saadatnia M, Javanmard S. Effects of opium addiction on  vascular endothelium. Journal of Isfahan Medical School. 2013;30:2084-90.
28. Haddadi F, Jazizadeh-Karimi M, Rostami Nejad M, Sokhtehzari S, Monazami AH, Asad MR. The Effect of Endurance Training on Addicted Women’s Level of Alkaline Phosphates Who Use Methadone. Report of Health Care. 2015;1(2):44-6.
29. Torabi S, Asad MR, Tabrizi A. The Effect of 8 Weeks of Moderate-Intensity Endurance Training on Serum Levels of Liver Enzymes and Insulin Resistance Index in Women with Type 2 Diabetes. Qom University of Medical Sciences Journal. 2017;11(7):47-55.