نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 . دانشجوی دکتری دانشکدۀ علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

2 دانشیار گروه فیزیولوژی ، دانشکده علوم ورزشی -دانشگاه اصفهان، اصفهان، ایران

3 استادیار مرکز تحقیقات رشد و نمو، بیمارستان امام حسین، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

اختلال در عملکرد اندوتلیال، نشانگر اولیۀ بیماری‌های قلبی و کاهش عملکرد طبیعی عروق خونی است. هدف کلی این مطالعه مقایسۀ اثر تمرینات مدرسه‌محور و تناوبی شدید رویmiR125a-5p، پروتئین واکنشگرC و نیمرخ لیپیدی نوجوانان دارای اضافه‌وزن و چاق بود. 45 دانش‌آموز پسر دارای اضافه‌وزن و چاق با میانگین سنی  1 ± 14 سال و شاخص تودۀ بدن (kg/m2 17/2±43/26) به شکل داوطلبانه و مساوی به گروه‌های مدرسه‌محور، تناوبی شدید و کنترل تقسیم شدند و به مدت 12هفته، هفته‌ای سه جلسه در تمرینات شرکت داشتند. تغییرات در سطوح miR125a، گردش خون، پروتئین واکنشگرC و نیمرخ لیپیدی قبل و بعد از مداخلات ورزشی اندازه‌گیری شد. نتایج نشان داد که مقادیر پروتئین واکنشگرC، شاخص تودة بدن، WHR، درصد چربی بدن، لیپوپروتئین کم‌چگال و سطوح تری‌گلیسرید در گروه‌های تجربی در مقایسه با گروه کنترل کاهش وجود داشت (05/0P≤). از سوی دیگر افزایش معنا‌داری در اوج اکسیژن مصرفی و مقادیر لیپوپروتئین پرچگال آزمودنی‌ها مشاهده شد (001/0P=)، اما تفاوت بین میانگین‌های گروه‌های تجربی در هر دو متغیر معنا‌دار نبود (15/0P=). همچنین افزایش معنا‌داری در سطوحmiR-125a-5p  گروه‌ها وجود داشت و تفاوت بین گروه‌های تجربی نیز معنا‌دار بود (001/0P=). در مجموع به‌نظر می‌رسد هر دو شیوۀ تمرینی سبب بهبود عملکرد اندوتلیال و  نیمرخ لیپیدی می‌شوند، اما تمرینات مدرسه‌محور در سنین نوجوانی اثربخشی نسبتاً بیشتری دارند. بنابراین، با توجه به ماهیت دشوار اجرای تمرینات تناوبی شدید در کودکان چاق، بهره‌گیری بیشتر از تمرینات مدرسه‌محور پیشنهاد می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A Comparison of the Effect of High Intensity Interval Training and School –Based Training on has-miR125a-5p, CRP and Lipid Profile of Overweight and Obese Adolescents

نویسندگان [English]

  • Sadegh Valipoor 1
  • Vazgan Minasian 2
  • Silva Hovsepian 3

1 PhD Student, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

2 Associate Professor, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

3 Assistant Professor, Child Growth and Development Research Center, Imam Hossein Children's Hospital, Isfahan, Iran

چکیده [English]

Endothelial dysfunction is an early indicator of cardiac diseases, and loss of normal homeostatic function in the blood vessels. The aim of this study was to compare the effect of school-based and high intensity interval training on miR125a-5p, C-reactive protein and lipid profile of overweight and obese adolescents. 45 overweight and obese male students (mean age 14±1 years, body mass index 26.43±2.17 kg/m2) were voluntarily divided into three equal groups: school-based training, high intensity interval training and control. Subjects participated in the training for12 weeks and 3 sessions per week. Changes of circulating miR125a-5p, C-reactive protein and lipid profile were measured before and after the training interventions. Findings revealed that C-reactive protein, body mass index, WHR, body fat percentage, low-density lipoprotein, and triglyceride of experimental subjects decreased compared with the control group (P≤0.05). There were significant increases in the VO2 peak and high density lipoprotein levels of subjects (P=0.001), but the differences between experimental groups were not significant in both variables (P=0.15). Also, there was a significant increase in the levels of miR125a-5p, and the difference between the experimental groups was significant (P=0.001). Generally, it seems that both types of training improved the endothelial function and lipid profile, but school-based training is relatively more effective in adolescents. Therefore, based on the difficult nature of high intensity interval training for obese children, further use of school-based training is suggested.

کلیدواژه‌ها [English]

  • CRP
  • miR125a-5p
  • obesity
  • training interventions
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