تأثیر مصرف عصارۀ استویا و تمرین هوازی بر میزان امنتین -1 سرمی و نیمرخ لیپیدی در رت‌های دیابتی‌شده با STZ

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران

2 دانشیار گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه رازی ، کرمانشاه، ایران.

3 .دانشیار گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه رازی ، کرمانشاه، ایران

چکیده

امنتین-1، آدیپوکین مترشح از بافت چربی احشایی، در توسعۀ اختلالات مرتبط با دیابت (همچون مقاومت انسولینی و دیس لیپیدمی) نقش دارد. ضمن استفاده از تمرینات هوازی به‌دلیل تأثیرات مثبت آنها، ﺗﺤﻘﯿﻘﺎت ﺟﺪﯾﺪ ﺑﻬﺮهﻣﻨﺪی از ﮔﯿﺎﻫﺎن داروﯾﯽ را در ﺑﻬﺒﻮد ﺳﻄﺢ ﺳﻼﻣﺖ، ﭘﯿﺸﮕﯿﺮی و ﻫﻤﭽﻨﯿﻦ درﻣﺎن ﺑﯿﻤﺎری دﯾﺎﺑﺖ ﻣﺆﺛﺮ ﻣﯽداﻧﻨﺪ. یکی از اﯾﻦ ﮔﯿﺎﻫﺎن، ﮔﯿﺎه اﺳﺘﻮﯾﺎست. هدف این پژوهش، بررسی اثر تمرین هوازی و مصرف عصارۀ استویا، بر میزان امنتین-1 سرمی و نیمرخ لیپیدی در رت‌های دیابتی بود. 35 ﺳﺮ رت ﻧﺮ در محدودۀ وزنی180تا220 ﮔﺮم به‌طور ﺗﺼﺎدﻓﻲ به گروه‌های ﻛﻨﺘﺮل ﻏﻴﺮدﻳﺎﺑﺘﻲ، ﻛﻨﺘﺮل دﻳﺎﺑﺘﻲ، دﻳﺎﺑﺘﻲ ﺗﻤﺮﻳﻦ، دیابتی عصاره و دیابتی تمرین همراه با استویا تقسیم شدند. ﺗﻤﺮﻳنات هوازی ﺷﺎﻣﻞ دویدن بر روی تردمیل (5 روز در ﻫﻔﺘﻪ، ﺑه مدت 6 ﻫﻔﺘﻪ) بود، دریافت عصاره نیز در همین مدت ادامه یافت. در پایان مداخله نمونه‌های خونی به‌منظور سنجش مقادیر امنتین-1 و نیمرخ لیپیدی به‌دست آمد. داده‌ها ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن آنوآ یکسویه و آزمون توکی ﺗﺤﻠﯿﻞ شد. نتایج نشان داد ﺳﻄﻮح ﺳﺮﻣﯽ اﻣﻨﺘﯿﻦ- 1 در ﮔﺮوه ﮐﻨﺘﺮل دﯾﺎﺑﺘﯽ در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﮔﺮوه ﮐﻨﺘﺮل ﻏﯿﺮدﯾﺎﺑﺘﯽ ﭘﺎﯾﯿﻦﺗﺮ ﺑﻮد (001/0= P). برنامۀ تمرینی هوازی و دریافت استویا به افزایش معنادار امنتین-1 و HDL و کاهش معنادار TG ، TC،  LDLو  VLDLدر گروه‌های تجربی نسبت به گروه کنترل دیابتی منجر شد (05/0P<). اﻳﻦ ﻧﺘﺎﻳﺞ ﺣﺎﻛﻲ از افزایش اﻣﻨﺘﻴﻦ-1 و بهبود ﭘﺮوﻓﺎﻳﻞ ﻟﻴﭙﻴﺪی پس از انجام تمرین هوازی و مصرف استویا بود. این تأثیرات هنگام استفادۀ همزمان از تمرین و استویا بیشتر بود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Stevia Extract Consumption and Aerobic Exercise on Serum Omentin-1 and Lipid Profile in STZ Induced Diabetic Rats

نویسندگان [English]

  • abdollah akbari 1
  • vahid tadibi 2
  • N Behpour 3
1 PhD Student, Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2 Associate Professor; Department of exercise physiology, Faculty of Physical of Physical Education and Sport Sciences, Razi University , Kermanshah, Iran.
3 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Razi University , Kermanshah, Iran
چکیده [English]

Omentin-1 (adipokine derived from visceral adipose tissue) is associated with the development of diabetic disorders (such as insulin resistance and dyslipidemia). While aerobic exercises are employed due to their positive effects, new research has shown that medicinal plants are effective in improving the health and preventing and treating diabetes. One of these plants is the Stevia plant. The aim of this study was to investigate the effect of aerobic exercise and stevia extract consumption on serum omentin-1 and lipid profile in diabetic rats. 35 male rats (180-220 g weight range) were randomly divided into non-diabetic control, diabetic control, diabetic exercise, diabetic extract, and diabetic exercise along with stevia groups. Aerobic exercises included running on the treadmill, 5 days a week for 6 weeks and the extract was received in the same period. At the end of the intervention, blood samples were collected to measure the omentin-1 levels and lipid profile. Data were analyzed by one-way ANOVA and Tukey test.Results showed that omentin-1 levels in diabetic control group were lower than non-diabetic control group (P=0.001). The aerobic exercise program and stevia consumption significantly increased omentin-1 and HDL and significantly decreased TG, TC, LDL and VLDL in the experimental groups compared with the diabetic control group (P<0.05). These results indicated an increase in omentin-1 and improvement of lipid profile after aerobic exercise and stevia extract consumption. These effects were higher when exercise and stevia were used simultaneously.

کلیدواژه‌ها [English]

  • Adipokine
  • aerobic exercise
  • diabetes
  • omentin
  • Stevia
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