مقایسۀ تأثیر هشت هفته تمرین هوازی و مقاومتی بر عوامل آنژیوژنیکی( VEGF ( و آنژیوستاتیکی ) ES ( در زنان غیرفعال

نوع مقاله : مقاله پژوهشی


1 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

2 استاد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

3 دانشیار فیزیولوژی ورزشی، دانشکدة تربیت بدنی و علوم وررزشی، دانشگاه تهران، تهران، ایران


آنژیوژنز فرایندی حیاتی در رشد و توسعۀ بافتی به‌ویژه بافت عضلانی محسوب می‌شود که تحت تأثیر انقباض عضلانی قرار می‌گیرد. مدالیته‌های تمرینی مختلف می‌توانند بر تعادل عوامل آنژیوژنیکی و آنژیوستاتیکی تأثیر داشته باشند. ازاین‌رو هدف پژوهش حاضر بررسی تأثیر 8 هفته تمرین هوازی و مقاومتی بر فاکتور رشد اندوتلیال عروقی (VEGF) و اندوستانین (ES) در زنان غیرفعال بود. 30 زن غیرفعال به‌طور تصادفی در سه گروه تمرین هوازی، مقاومتی و کنترل قرار گرفتند. تمرین مقاومتی به مدت 8 هفته، سه جلسه در هفته و با 3 ست 10 تکراری با شدت 60 تا 70 درصد 1RM برای نه حرکت، تمرین هوازی به مدت 8 هفته، 3 جلسه در هفته و هر جلسه به مدت 30 دقیقه با شدت 65 تا 70 درصد ضربان قلب بیشینه انجام گرفت. 48 ساعت قبل و بعد از آخرین جلسۀ تمرینی در شرایط ناشتا، خون‌گیری از گروه‌های پژوهش انجام شد. مقادیر VEGF و ES با استفاده از کیت به روش ELISA اندازه‌گیری شد. داده‌های پژوهش با استفاده از آزمون آماری t همبسته و ANOVA در سطح معناداری (05/0>P) تجزیه‌وتحلیل شدند. نتایج درون‌گروهی پژوهش حاضر نشان داد برنامۀ تمرین هوازی و مقاومتی به‌طور معناداری مقادیر سرمی VEGF را افزایش و ES را کاهش داد. همچنین، نتایج آزمون ANOVA و آزمون تعقیبی توکی نیز نشان داد بین تمرین هوازی و مقاومتی در مقادیر VEGF و ES تفاوت معناداری وجود ندارد (05/0<P). نتایج پژوهش حاضر نشان داد تمرین مقاومتی می‌تواند آثار مشابه تمرین استقامتی در کنترل و تعادل مثبت آنژیوژنزی داشته باشد.


عنوان مقاله [English]

The Comparison of the Effect of 8 Weeks of Aerobic and Resistance Training on Angiogenic (VEGF) and Angiostatic (ES) Factors in Sedentary Women

نویسندگان [English]

  • javad tolouei azar 1
  • ali asghar ravasi 2
  • Rahman Soori 3
  • Ali Akbarnejad 3
1 Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
2 Professor of exercise Physiology, Faculty of physical education and sport sciences, University of Tehran, Tehran, Iran.
3 Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
چکیده [English]

Angiogenesis is a vital process in growth and development of tissues, especially muscle tissues that is affected by muscle contraction. Different training modalities can affect the balance between angiogenic and angiostatic factors. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic and resistance training on vascular endothelial growth factor (VEGF) and endostatin (ES) in sedentary women. 30 sedentary women were randomly assigned to 3 groups: aerobic, resistance and control. Resistance training was performed for 8 weeks, 3 sessions per week and three 10-repetiton sets with intensity of 60-70% of 1RM for 9 movements. Aerobic training was performed for 8 weeks, 3 sessions per week, 30 minutes each session with intensity of 65-70% of maximum heart rate. Blood samples were collected 48 hours before and after the last training session in the fasting state. VEGF and ES values were measured using ELISA kit. Data were analyzed by dependent t test and ANOVA at (P<0.05). Intra-group results showed that aerobic and resistance training significantly increased serum levels of VEGF and significantly decreased ES. Also, the results of ANOVA and Tukey post hoc test revealed no significant difference in the amounts of VEGF and ES between resistance and aerobic training (P>0.05). The results of this study showed that resistance training could have the same effects as endurance training in the control and positive balance of angiogenesis

کلیدواژه‌ها [English]

  • Aerobic training
  • angiogenesis
  • endostatin
  • resistance training
  • sedentary women
  • vascular endothelial growth factor
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