نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 دکتری تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

2 استاد، دکتری تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

3 دانشیار، دکتری تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

چکیده

VEGF قوی‌ترین میتوژن مخصوص سلول‌های آندوتلیال، فاکتور اصلی در رخداد فرایند آنژیوژنز است. ازاین‌رو هدف از تحقیق حاضر، بررسی پاسخ فاکتور رشدی آندوتلیال عروقی (VEGF) و هورمون کورتیزول سرمی، به یک جلسه فعالیت تناوبی شدید و تعیین ارتباط بین سطوح سرمی آنهاست. به همین منظور 11 مرد غیرورزشکار (میانگین سنی 80/23 سال) داوطلبانه انتخاب شدند و به اجرای یک جلسه فعالیت تناوبی شدید پرداختند. نمونه‌های خونی قبل، بلافاصله و دو ساعت بعد از اجرای فعالیت گرفته شد. از آزمون آماری تحلیل واریانس با اندازه‌های تکراری (Repeated Measures) و آزمون همبستگی پیرسون برای آنالیز داده‌ها استفاده شد. بلافاصله بعد از اجرای فعالیت، کاهش سطح VEGF سرمی به‌صورت غیرمعنادار مشاهده شد (74/10 درصد). سطح VEGF سرمی دو ساعت پس از اجرای فعالیت افزایش یافت و به مقداری بالاتر از سطح استراحتی رسید (20/13 درصد). سطوح کورتیزول سرمی بلافاصله و دو ساعت بعد از اجرا کاهش یافت که این کاهش فقط در مرحلۀ 2 ساعت بعد از اجرای فعالیت نسبت به سطح استراحتی معنادار بود. علاوه‌بر این، هیچ ارتباط معناداری بین سطوح VEGF و کورتیزول سرمی در مراحل قبل، بلافاصله و دو ساعت بعد از اجرای فعالیت ورزشی مشاهده نشد. به‌طور کلی می‌توان نتیجه گرفت که اجرای یک جلسه فعالیت تناوبی شدید، احتمالاً تأثیرات معناداری بر سطوح VEGF سرمی ندارد و از طرفی می‌تواند موجب کاهش هورمون کورتیزول آزاد سرمی شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Responses of Vascular Endothelial Growth Factor and Cortisol Hormone to a Session of High Intensity Interval Training and the Relationship between Their Serum Levels

نویسندگان [English]

  • mehdi yadegari 1
  • ali asghar ravasi 2
  • Siroos Choobineh 3

1 PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran

2 . Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 Associate professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

چکیده [English]

VEGF as the most potent mitogen related to endothelial cells is the main factor in the incidence of angiogenesis process. Thus the aim of the present study was to examine the responses of VEGF and serum cortisol to a session of high intensity interval training and to determine the relationship between their serum levels. 11 non-athlete men (mean age 23.80 years) were selected voluntarily and participated in a session of high intensity interval training. Blood samples were collected before, immediately and 2 hours after the training. Analysis of variance (ANOVA) with repeated measures and Pearson correlation test were used to analyze data. Serum VEGF decreased insignificantly immediately after the training (10.74%) while it increased 2 hours after the training and reached above the rest level (13.20). The serum cortisol decreased immediately and 2 hours after the training and this reduction was significant only in the phase of 2 hours after the training compared with the rest level. There was no significant relationship between VEGF and serum cortisol before, immediately and 2 hours after the training. In general, it can be concluded that a session of high intensity interval training may not have significant effects on serum VEGF levels and on the other hand, it can reduce serum free cortisol hormone.

کلیدواژه‌ها [English]

  • angiogenesis
  • capillary density
  • cortisol hormone
  • growth factor
  • interval training
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