ردیابی گیرنده عامل رشد اندوتلیال عروقی-2 و حجم عروق ریوی پس از 6 هفته تمرین تناوبی شدید

نوع مقاله: مقاله پژوهشی

نویسندگان

1 استاد، دکتری تخصصی فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

2 استادیار، دکتری تخصصی بافت‌شناسی، گروه علوم پایه دانشکدۀ دامپزشکی، دانشگاه تبریز، تبریز، ایران

3 . دکتری تخصصی فیزیولوژی ورزشی،گروه فیزیولوژی ورزشی دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

چکیده

گیرنده دوم فاکتور رشد اندوتلیال عروقی(VEGFR-2) قوی ترین پیام رسان آنژیوژنیک مرتبط با VEGFاست . هدف مطالعه حاضر بررسی تاثیر یک دوره تمرین تناوبی شدید بر بیان VEGFR-2 و حجم عروق ریوی رت های نر بود. این پژوهش از جمله مطالعات تجربی بود که نمونه های آن را 10 سر رت نر نژاد ویستار تشکیل داده بودند که به طور تصادفی و به صورت مساوی به گروه‌ تمرین و کنترل تقسم شدند.رت‌ها در طی 6 هفته، برنامه تمرین تناوبی شدید را با سرعت 25 متر بر دقیقه شروع و با سرعت 70 متر بر دقیقه به پایان رساندند.هر جلسه تمرین شامل10 تکرار 1 دقیقه ای با مراحل استراحت 2 دقیقه ای در بین دوره ها بود. در پایان، جهت انجام آزمایشهای ایمونوهیستوشیمیایی و استریولوژی بافت ریه خارج گردید. تجزیه و تحلیل آماری با استفاده آزمون t مستقل و ضریب همبستگی پیرسون نشان از افزایش معنادار VEGFR-2(001/0 sig ) و حجم عروق ریوی(042/0 sig )در گروه تمرین نسبت به گروه کنترل و همچنین وجود ارتباط مثبت و نسبتا قوی بین تغییرات این دو شاخص با تمرین ورزشی داشت (035/0 sig ). به طور کلی به نظر می رسد 6 هفته تمرین تناوبی شدید پتانسیل پیشبرد فرایندهای پروآنژیوژنیک ریوی را دارا است.

کلیدواژه‌ها


عنوان مقاله [English]

vascular endothelial growth factor receptor-2 and the pulmonary vascular volume Tracking, after 6 weeks of high-intensity interval training

نویسندگان [English]

  • shadmehr Mirdar 1
  • gholamreza Hamidiyan 2
  • mehdi yadegari 3
1 Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
2 Assistant Professor, PhD of Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
3 . PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
چکیده [English]

VEGF-2 has most potent angiogenic signaling associated with VEGF that So far,no has been published research in relation to the effect of exercise training on the vascular volume and it, in the lung . therefore, present study aim was investigate the effect of an high-intensity interval training period on VEGFR-2 expression and pulmonary vascular volume in male Wistar rats. This research including the experimental studies that samples its had formed 10 male Wistar rats,that to form of Randomly and equally were divided into training and control groups. Training program Was started with 25 meters per minute and with 70 meters per minute was Finished at the end of the period. In each training session, rats completed the 1-min activity with 10 repetition and work to rest ratio was 1:2. In the end, lung tissue extracted for stereologicaly and Immunohistochemistry tests. Statistical analysis whit Independent t-test, and Pearson correlation coefficient showed, significantly increase in VEGFR-2(sig: 0/001) and pulmonary vascular volume(sig: 0/042) in the exercise group compared to the control group, and positive correlation between changes in these two indicators whit exercise(sig: 0/035). In general it seems that 6 weeks of high-intensity interval training has potential to promote of lung angiogenic processes.

کلیدواژه‌ها [English]

  • high intensity interval training
  • Lung
  • Vascular andothelial growth factor
  • Vascular volume

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