نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I
نویسندگان
1 دانشجوی دکتری سلامت در بلایا و فوریتها، دانشگاه علوم پزشکیکرمان،کرمان، ایران
2 . کارشناس ارشد فیزیولوژی ورزشی، دانشگاه تهران،تهران، ایران
3 دانشیارگروه فیزیولوژی ورزشی دانشگاه تهران، تهران،ایران
4 کارشناس ارشد آسیب شناسی و حرکات اصلاحی دانشگاه تهران،تهران، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Mir-210 is pro-angiogenic micro-RNA in endothelial cells that improves angiogenesis process by suppressing (EphrinA3) and increasing the migration of some gene and protein targets (VEGF). In this study, 12 male rats (age: 8 weeks, mean weight: 180±20 g) were selected and randomly divided into control (n=6) and exercise (n=6) groups. High intensity interval training was performed for 4 weeks, 5 days a week including 3 high intervals (4 minutes at 90-100% of VO2max) and 3 low intervals (2 minutes at 50-60% VO2max). Gene expression was calculated by Real time-PCR technique and 2-∆∆CT. Independent t test was used to determine the significance of variables between the groups.The results showed that high intensity interval training significantly changed the increase of gene expression of Mir-210 and VEGF (P=0.005) (P=0.003). Also, the decrease in gene expression of EphrinA3 receptor in the exercise group was significant compared with the control group (P=0.000). Generally, perhaps due to hypoxiawhich happened along with high intensity interval training, increased gene expression of Mir-210 and VEGF improved the pro-angiogenic function of endothelial cells and this adaptation increased angiogenesis in rats.
کلیدواژهها [English]