نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 دکتری فیزیولوژی ورزش دانشکدۀ تربیت ‌بدنی دانشگاه تهران

2 استاد دانشکدۀ تربیت ‌بدنی

3 دانشیار فیزیولوژی ورزش دانشکده تربیت بدنی دانشگاه تهران،ایران

4 دانشیار بیوشیمی، مرکز تحقیقات سلولی و مولکولی، پژوهشکدۀ علوم غدد درون‌ریز، دانشگاه علوم‌پزشکی شهیدبهشتی

چکیده

اپلین، ادیپوکاینی جدید است که مهم‌ترین نقش فیزیولوژیکی آن، تعامل مستقیم با هورمون انسولین است. هدف اصلی این تحقیق، بررسی اثر دوازده هفته تمرینات ترکیبی بر اپلین پلاسما و مقاومت انسولینی زنان نسبتاً چاق بود. بدین منظور، چهل دانشجو با BMI بیش از 25 و غیرورزشکار، به‌صورت تصادفی از بین بیش از چهارصد دانشجوی واجد شرایط، پس از تکمیل رضایت‌نامه و پرسش‌نامۀ سلامت جسمانی و فعالیت بدنی انتخاب و به‌وسیلۀ جدول اعداد تصادفی، به دو گروه تجربی و کنترل تقسیم شدند. پروتکل تمرینی گروه تجربی، دوازده هفته شامل هفت جلسه فعالیت در هفته بود که چهار جلسه را تمرینات استقامتی شامل تمرینات تناوبی دویدن ملایم یا پیاده‌روی تند، دو جلسه را تمرینات مقاومتی به روش دایره‌ای و یک جلسه را تمرینات هندبال به خود اختصاص داد. نمونه‌گیری خون از دو گروه، پس از 12 ساعت ناشتایی و در دو نوبتِ قبل از شروع برنامۀ تمرینی و 72 ساعت پس از پایان برنامۀ تمرینی انجام پذیرفت. مقادیر اپلین و انسولین پلاسما با روش الایزا اندازه‌گیری شد. به‌منظور مقایسۀ متغیرها بین دو گروه تجربی و کنترل، از آزمون آماری ANOVA با اندازه‌گیری‌های مکرر (2×2)، در سطح 05/0p <  استفاده شد. بر اساس نتایج، کاهش معنی‌داری در مقادیر اپلین (035/0p =)، شاخص مقاومت انسولینی (014/0p =) و تودۀ چربی (001/0p <) گروه تجربی پس از دورۀ تمرینی ملاحظه شد. این نتایج، نقش محوری کاهش وزن را در بهبود هم‌زمان الگوی ترشح ادیپوسایتوکاین اپلین و حساسیت انسولینی نمایان ساخت.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of 12 Weeks of Combined Training on Plasma Apelin and Insulin Resistance in Overweight Women

نویسندگان [English]

  • Masumeh Helalizadeh 1
  • Abas Gaeini 2
  • Mohammad Reza Kordi 3
  • Ali Asghar Ravasi 2
  • Mehdi Hedayati 4

1 PhD of Exersice Physiologhy, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 . Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

4 . Associate Professor of Biochemistry, Cellular & Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده [English]

The most important physiological role of apelin as a novel adipokine is co- relation with insulin hormone. The aim of this study was to investigate the effects of 12 weeks combined training on plasma apelin and insulin resistance index in overweight females. Therefore, 40 non athlete and over weight female students (BMI, 25-30), were selected and divided randomly in two experimental and control groups, equally. Training program was done seven days a week for 12 weeks. The endurance training program, which was performed four sessions per week, included intermittent running and walking. Two sessions per week were assigned to progressive resistance training consisted of circuit trainings. One session per week was also allocated to handball training. Blood samples were taken in fasting state from all subjects. Plasma apelin and insulin concentrates were determined by ELISA test. The statistical analyze of research was done by Repeated ANOVA (2×2), at the significance level of p

کلیدواژه‌ها [English]

  • adipocytokine
  • apelin
  • combined training
  • Insulin sensitivity
  • overweight
 
 
 
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