تأثیر دو شیوۀ تمرین هوازی (تداومی و تناوبی) و مکمل‌یاری با کمپلکس وانادیم- روی بر بیان ژن‌های آنتی‌اکسیدانی در بافت بیضۀ رت‌های تغذیه‌شده با محلول فروکتوز

حامد چمن, نادر; صفرزاده, علی رضا; حمیدیان, غلامرضا; نصیری, خدیجه

doi:10.22059/jsb.2023.361255.1594

نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

¹ گروه فیزیولوژی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.

² نویسنده مسِئول، گروه فیزیولوژی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.

³ گروه دامپزشکی، دانشکدۀ علوم پایه، دانشگاه تبریز، تبریز، ایران.

https://doi.org/10.22059/jsb.2023.361255.1594

چکیده

مقدمه: مصرف زیاد فروکتوز به ایجاد مقاومت به انسولین و افزایش استرس اکسایشی در بافت‌های مختلف بدن از جمله بافت بیضه منجر می‌شود. هدف پژوهش حاضر بررسی تأثیر تمرینات هوازی (تداومی و تناوبی) و مکمل‌یاری با وانادیم-روی بر بیان ژن‌های آنتی‌اکسیدانی بافت بیضه در رت‌های تغذیه‌شده با شربت فروکتوز بود.
روش پژوهش: 56 سر رت نر در هفت گروه شامل کنترل نرمال (NC)، کنترل فروکتوز (FC)، تمرین تداومی با شدت متوسط (FCT)، تمرین تناوبی با شدت بالا (FIT)، مکمل وانادیم-روی (FS)، تمرین تداومی با شدت متوسط+ مکمل وانادیم-روی (FSCT) و تمرین تناوبی با شدت بالا+مکمل وانادیم-روی (FSIT) قرار گرفتند. بیان ژن‌های GPX، SOD و CAT در بافت بیضه و سطوح سرمی TAC، TOC، گلوکز، انسولین و HOMA-IR ارزیابی شد. تحلیل آماری توسط آزمون‌های آنووای یکسویه و تعقیبی بنفرونی در سطح معناداری ( P≤0.05) تجزیه‌وتحلیل شد.
یافته‌ها: مصرف 16 هفته شربت فروکتوز به افزایش معنادار سطوح سرمی گلوکز، HOMA-IR و TOC و کاهش معنادار TAC سرم و بیان ژن‌های GPX، SOD و CAT در بافت بیضۀ گروه FC در مقایسه با گروه NC منجر شد (P<0.05). هشت هفته مصرف مکمل وانادیم-روی و تمرینات هوازی (تداومی و تناوبی) موجب کاهش سطوح سرمی گلوکز، HOMA-IR و TOC و افزایش TAC سرم و بیان ژن‌های GPX، SOD و CAT در مقایسه با گروه FC شد (P<0.05).
نتیجه‌گیری: نتایج این تحقیق نشان می‌دهد تمرینات هوازی (تداومی و تناوبی) و مصرف مکمل وانادیم-روی موجب بهبود وضعیت متابولیکی و متعاقب آن بهبود وضعیت اکسایشی در آزمودنی‌های مبتلا به مقاومت انسولینی می‌شود.

کلیدواژه‌ها

موضوعات

فیزیولوژی ورزشی

عنوان مقاله [English]

The Effect of Two Types of Aerobic Training (Continuous and Interval) and Vanadium-Zinc Complex Supplementation on Antioxidant Genes Expression in the Testicular Tissue of Rats Fed With Fructose Solution

نویسندگان [English]

Nader Hamedchaman ¹
Alireza Safarzade ²
Gholamreza Hamidian ³
Khadijeh Nasiri ¹

¹ Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran.

² Corresponding Author, Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran.

³ Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

چکیده [English]

Introduction: Excessive fructose consumption induces insulin resistance and elevates oxidative stress levels in various body tissues, including the testicular tissue. The present study aimed to investigate the effects of aerobic training (continuous and interval) and vanadium-zinc supplementation on the expression of antioxidant genes in testicular tissue in rats fed with fructose syrup.
Methods: fifty-six male rats were divided into seven groups including normal control (NC), fructose control (FC), moderate-intensity continuous training (FCT), high-intensity interval training (FIT), vanadium-zinc supplement (FS), moderate-intensity continuous training+vanadium-zinc supplement (FSCT) and high-intensity interval training+vanadium-zinc supplement (FSIT). The GPX, SOD, and CAT genes expression in testicular tissue and serum levels of TAC, TOC, glucose, insulin, and HOMA-IR were measured. One-way ANOVA and Bonferroni post-hoc tests were used for data analysis at a significant level of P≤0.05.
Results: Sixteen weeks of fructose syrup consumption led to a significant increase in serum glucose, HOMA-IR, and TOC levels and a significant decrease in serum TAC, and the levels of GPX, SOD, and CAT gene expression in the testicular tissue of the FC group compared with NC group (P<0.05). Eight weeks of vanadium-zinc supplementation and aerobic training (continuous and interval) were associated with a decrease in serum glucose, HOMA-IR, and TOC levels and an increase in serum TAC and levels of GPX, SOD, and CAT gene expression compared with the FC group (P<0.05).
Conclusion: The results of this research showed that aerobic training (continuous and interval) and vanadium-zinc supplementation improve the metabolic status and subsequently improve the oxidative status in subjects suffering from insulin resistance.

کلیدواژه‌ها [English]

Aerobic Training
Insulin Resistance
Stress Oxidative
Vanadium
Zinc

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[69] Alshammari E, Shafi S, Nurmi-Lawton J, Taylor A, Lanham-New S, Ferns G. Altered antioxidant and trace-element status in adolescent female gymnasts. International journal of sport nutrition and exercise metabolism. 2010 Aug 1;20(4):291-8. https://doi.org/10.1123/ijsnem.20.4.291

[70] Koury JC, Portella ES, de Oliveira CF, Lopes GC, Donangelo CM. Zinc and Copper Biochemical lndices of Antioxidant Status in Elite Athletes of Different Modalities. International Journal of Sport Nutrition & Exercise Metabolism. 2004 Jun 1;14(3). https://doi.org/10.1123/ijsnem.14.3.358.

تأثیر دو شیوۀ تمرین هوازی (تداومی و تناوبی) و مکمل‌یاری با کمپلکس وانادیم- روی بر بیان ژن‌های آنتی‌اکسیدانی در بافت بیضۀ رت‌های تغذیه‌شده با محلول فروکتوز

مراجع

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دوره 15، شماره 4دی 1402صفحه 21-38

دوره 15، شماره 4
دی 1402
صفحه 21-38