نشریه علوم زیستی ورزشی

شماره جاری

بر اساس شماره‌های نشریه

بر اساس نویسندگان

بر اساس موضوعات

نمایه نویسندگان

نمایه کلیدواژه ها

درباره نشریه

اهداف و چشم انداز

اعضای هیات تحریریه

سیاست شورای سردبیری و مجله

سیاست دسترسی آزاد

اصول اخلاقی انتشار مقاله

بانک ها و نمایه نامه ها

پیوندهای مفید

فرایند پذیرش مقالات

اخبار و اعلانات

اطلاعات آماری نشریه

لینک صفحات مجله در شبکه های اجتماعی

راهنمای نویسندگان

فرم ها

داوران

راهنمای عضویت و ثبت داوری در Publons

تأثیر دوازده هفته تمرین مقاومتی و هوازی بر مقادیر سرمی CTRP-12 وLCN-2 در زنان مبتلا به دیابت نوع 2

نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 گروه علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه مراغه، مراغه، ایران.

2 نویسندۀ مسئول، گروه علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه مراغه، مراغه، ایران.

چکیده

مقدمه: لیپوکالین 2 و CTRP-12 آدیپوکاینی است که با دیابت نوع دو ارتباط نزدیکی دارد و در بافت چربی بیان می‌شود. ازاین‌رو هدف از تحقیق حاضر بررسی تأثیر 12 هفته تمرین مقاومتی و هوازی بر مقادیر سرمی CTRP-12 و  LCN-2در زنان مبتلا به دیابت نوع 2 است.
روش پژوهش: تحقیق حاضر به‌صورت نیمه‌تجربی انجام گرفت. جامعۀ آماری پژوهش را تمامی زنان مبتلا به دیابت نوع 2 شهرستان ارومیه تشکیل دادند که از بین آنها 30 زن مبتلا به دیابت نوع 2 در محدودۀ سنی 40-45 سال انتخاب شدند و به‌طور تصادفی در سه گروه تمرین مقاومتی (سه ست با 10 تکرار و شدت 30 تا 75 درصد 1RM)، تمرین هوازی (15 تا 45 دقیقه با شدت 50 تا 75 درصد RHR) و گروه کنترل قرار گرفتند. گروه‌های تمرینی به مدت 12 هفته و هر هفته سه جلسه به تمرین پرداختند. مقادیر سرمی CTRP-12  و LCN-2 با استفاده از کیت به روش ELISA اندازه‌گیری شد. برای تجزیه‌وتحلیل داده‌ها از آزمون آماری تی همبسته و آنوا در سطح معناداری کمتر از 5 درصد استفاده شد.
یافته‌ها: مقادیر CTRP-12  گروه‌های تمرین مقاومتی و هوازی به‌طور معناداری افزایش یافت، درحالی‌که مقادیر LCN-2 در این دو گروه نسبت به گروه کنترل کاهش معناداری نشان داد (05/0P<). در بررسی بین‌گروهی، تمرین مقاومتی و هوازی تغییرات معناداری را در CTRP-12  و LCN-2 نسبت به گروه کنترل ایجاد کرد (05/0P<).
نتیجه‌گیری: به‌نظر می‌رسد که انجام تمرینات مقاومتی و هوازی، تنظیم افزایشی آدیپوکاین‌های ضدالتهابی (CTRP-12) و تنظیم کاهشی آدیپوکاین التهابی لیپوکالین-2 (LCN-2) دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes

نویسندگان [English]

  • Morteza Fattahpour Marandi 1
  • Solmaz Babaei 2

1 Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

2 Corresponding Author, Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

چکیده [English]

Introduction: Lipocalin-2 (LCN-2) and CTRP-12 are adipokines that are closely related to type-2 diabetes and are expressed in adipose tissue. Therefore, this research aimed to investigate the effect of 12 weeks of resistance and aerobic training on the serum levels of CTRP-12 and LCN-2 in women with type-2 diabetes.
Methods: The present research was conducted in a quasi-experimental manner. The statistical population of the study included all women with type-2 diabetes in Urmia city, from which 30 women with type-2 diabetes in the age range of 40-45 years old were selected and randomly assigned into three Resistance Training (three sets with 10 repetitions at 30 to 75% of 1RM), Aerobic Training (15 to 45 minutes at 50 to 75% of RHR), and Control groups. The training groups practiced for 12 weeks and three sessions per week. Serum levels of CTRP-12 and LCN-2 were measured using an ELISA kit. To analyze the data, dependent t, and ANOVA tests were used at a significance level of less than 5%.
Results: In the resistance and aerobic training groups, the values of CTRP-12 increased significantly, while the values of LCN-2 in these two groups decreased significantly compared with the control group (p<0/05). In the between-group analysis, resistance and aerobic training produced significant changes in CTRP-12 and LCN-2 compared with the control group (p<0/05).
Conclusion: It seems that performing resistance and aerobic training induces up-regulation of anti-inflammatory adipokines (CTRP-12) and a down-regulation of the inflammatory adipokine lipocalin-2 (LCN-2).

کلیدواژه‌ها [English]

  • Aerobic Training
  • CTRP-12
  • Lipocalin-2
  • Tesistance Training
  • Type-2 Diabetes
مراجع

[1] Shephard RJ. Obesity in 2018: Do we have an epidemic, and if so what caused it?. The Health & Fitness Journal of Canada. 2018 May 30;11(2):53-112. doi: 10.1038/nature18642

[2] Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, et al. The genetic architecture of type 2 diabetes. Nature. 2016;536(7614):41-9. doi: 10.1038/nature18642.

[3] Association AD. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1): S81-S90. https://doi.org/10.2337/dc14-s081.

[4] Froozandeh E, Tofighi A, Tolouei Azar J. Furin, CTRP-12, TNF-α and Lipid Profile Changes during 8 Weeks of Aerobic Interval and Resistance Training in Women with Type 2 Diabetes. Sport Physiology & Management Investigations. 2020 Nov 21;12(3):25-40. https://www.sportrc.ir/article_122670.html?lang=en (In Persian).

[5] Scherer PE, Hill JA. Obesity, diabetes, and cardiovascular diseases: a compendium. Circulation research. 2016 May 27;118(11):1703-5. https://doi.org/10.1161/circresaha.116.308999.

[6] Hoevenaars FP, Keijer J, van der Stelt I, Duivenvoorde LP, Herreman L, van Nes R, Friedecký D, Hegeman MA, Van Schothorst EM. White adipose tissue response of obese mice to ambient oxygen restriction at thermoneutrality: response markers identified, but no WAT inflammation. Genes. 2019 May 10;10(5):359. https://doi.org/10.3390/genes10050359.

[7] Espandar N, Tofighi A, Tolouei Azar J, Khadem Ansari M. H. The Effect of 8 Weeks of Resistance, Endurance, and Concurrent Training on Serum CTRP-12, Furin, KLF-15, Lipid Profiles and Insulin Resistance in Sedentary Obese Men. Sport Physiology. Spring 2021; 13 (49): 107-36. Doi: 10.22089/spj.2019.7444.1916.(In Persian).

[8] Hofmann C, Chen N, Obermeier F, Paul G, Büchler C, Kopp A, Falk W, Schäffler A. C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts. Inflammatory bowel diseases. 2011 Dec 1;17(12):2462-71. https://doi.org/10.1002/ibd.21647.

[9] Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. Journal of Biological Chemistry. 2011 Oct 7;286(40):34552-8. https://doi.org/10.1074/jbc.m111.277319.

[10] Guo B, Li Y. GW26-e4592 Implication of C1q/TNF-related protein-12 (CTRP-12) in patients with coronary artery disease. Journal of the American College of Cardiology. 2015 Oct 20;66(16S):C67-c67. https://doi.org/10.1016/j.jacc.2015.06.1281.

[11] Tan BK, Chen J, Adya R, Ramanjaneya M, Patel V, Randeva HS. Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway. J Endocrinol. 2013 Oct 4;219(2):101-8. https://doi.org/10.1530/joe-13-0277.

[12] Ohashi K, Shibata R, Murohara T, Ouchi N. Role of anti-inflammatory adipokines in obesity-related diseases. Trends in endocrinology & metabolism. 2014 Jul 1;25(7):348-55. https://doi.org/10.1016/j.tem.2014.03.009.

[13] Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, Wong GW. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. Journal of Biological Chemistry. 2012 Mar 23;287(13):10301-15. https://doi.org/10.1074/jbc.m111.303651.

[14] Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S. Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15. PloS one. 2013 Dec 16;8(12):e83183. https://doi.org/10.1371/journal.pone.0083183.

[15] Gorgani-Firuzjah M, Gorgani-Firuzjaee S. Elevated Serum CTRP12 (Adipoline) Level in Army Air Defense Personnel: A Case-Control Study. Paramedical Sciences and Military Health. 2017 Jun 10;12(1):1-6. 20.1001.1.2322164.1400.13.49.12.2 (In Persian).

[16] Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Molecular endocrinology. 2008 Jun 1;22(6):1416-26. https://doi.org/10.1210/me.2007-0420

[17] Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J. Dual action of neutrophil gelatinase–associated lipocalin. Journal of the American Society of Nephrology. 2007 Feb 1;18(2):407-13. https://doi.org/10.1681/asn.2006080882.

[18] Rashad NM, El‐Shal AS, Etewa RL, Wadea FM. Lipocalin‐2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women. IUBMB life. 2017 Feb;69(2):88-97. https://doi.org/10.1002/iub.1594

[19] Vaezi P, Zolfaghari MR, Toloueiazar J. Effects of 8 weeks aerobic training on serum level of CTRP9, omentin-1, lipid profile and insulin resistance in inactive obese woman. Journal of Applied Health Studies in Sport Physiology. 2018 Mar 21;5(1):45-52. 10.22049/JASSP.2019.26537.1209 (In Persian).

[20] Rezaeian N, Ravasi AA, Soori R, Akbarnezhad A, Mirshafiey SA, Towfighi F. Effect of resistance training on serum levels of adipolin and insulin resistance in obese women. Journal of Sport Biosciences. 2020 May 21;12(1):1-6. https://doi.org/10.22059/jsb.2020.125058.936. (In Persian).

[21] Rahmatollahi M, Ravasi A, Soori R. Effect of 8 Weeks of Low-Intensity Continuous Training on Plasma Adipolin, Insulin Resistance, and Weight of Fatty Fat-Filled Rats. Adv Obes Weight Manag Control. 2017;7(5):00211.  https://doi.org/10.15406/aowmc.2017.07.00211.(In Persian).

[22] Bijeh N, Abbasian S. Comparison of effects of ramadan fasting and regular aerobic exercise on lipocalin-2 (lcn2), lipid profile and insulin resistance in non-active obese men. Razi Journal of Medical Sciences. 2013 Sep 10;20(111):16-29. http://rjms.iums.ac.ir/article-1-2715-en.html (In Persian).

[23] Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, Baik SH, Choi DS, Kim SM. Effect of exercise training on A‐FABP, lipocalin‐2 and RBP4 levels in obese women. Clinical endocrinology. 2009 Apr;70(4):569-74. https://doi.org/10.1111/j.1365-2265.2008.03374.x

[24] Reilly T, Dowzer CN, Cable NT. The physiology of deep-water running. Journal of Sports Science. 2003 Dec 1;21(12):959-72. https://doi.org/10.1080/02640410310001641368.

[25] Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circulation research. 2010 Sep 17;107(6):810-7. https://doi.org/10.1161/circresaha.110.226357.

[26] Keating SE, Johnson NA, Mielke GI, Coombes JS. A systematic review and meta‐analysis of interval training versus moderate‐intensity continuous training on body adiposity. Obesity reviews. 2017 Aug;18(8):943-64. https://doi.org/10.1111/obr.12536.

[27] Froozandeh E, Tofighi A, Tolouei Azar J. The Effect of 8 Weeks of Resistance and Aerobic Interval Training on Levels of GLP-1, NRG-1 and IL-33 in Type 2 Diabetic Women. Sport Physiology, Summer 2020; 12(46): 117-38. (In Persian). DOI: 10.22089/spj.2019.7434.1913. (In Persian).

[28] Rahmatollahi M, Ravasi AA, Soori R, Onegh B, Dolati F. Adipolin and insulin resistance response to two types of exercise training in type 2 diabetic male rats. Endocrinol Metab Int J. 2018;6(1):36-40. https://doi.org/10.15406/emij.2018.06.00152. (In Persian)

[29] Tan BK, Chen J, Hu J, Amar O, Mattu HS, Ramanjaneya M, Patel V, Lehnert H, Randeva HS. Circulatory changes of the novel adipokine adipolin/CTRP 12 in response to metformin treatment and an oral glucose challenge in humans. Clinical endocrinology. 2014 Dec;81(6):841-6. https://doi.org/10.1111/cen.12438

[30] Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes care. 2003;26:S73. doi: 10.2337/diacare.26.2007.s73.

[31] Moghadasi M, Domieh AM. Effects of resistance versus endurance training on plasma lipocalin-2 in young men. Asian journal of sports medicine. 2014 Jun;5(2):108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374613/ (In Persian).

[32] Owen HC, Roberts SJ, Ahmed SF, Farquharson C. Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. American Journal of Physiology-Endocrinology and Metabolism. 2008 Jun;294(6):E1023-34. https://doi.org/10.1152/ajpendo.00586.2007.

[33] Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Molecular endocrinology. 2008 Jun 1;22(6):1416-26. https://doi.org/10.1210/me.2007-0420

[34] Domieh AM, Khajehlandi A. Effect of 8 weeks endurance training on plasma visfatin in middle-aged men. Brazilian Journal of Biomotricity. 2010;4(3):174-9. https://doi.org/10.1136/bjsm.2010.078725.68

[35] Da Luz G, Frederico MJ, da Silva S, Vitto MF, Cesconetto PA, de Pinho RA, Pauli JR, Silva AS, Cintra DE, Ropelle ER, De Souza CT. Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats. European journal of applied physiology. 2011 Sep;111:2015-23. https://doi.org/10.1007/s00421-010-1802-2

[36] Jafarzadeh Dehnavi M, Shemshaki A, Kordi M. Hedatati M. Effect of 8 weeks of aerobic interval tranining on levels of lipocalin-2, Glucose, insulin and insulin resistance in obesity women. Journal of Sport and Exercise Physiology.2015.8(11):1157-1165. https://joeppa.sbu.ac.ir/article_98736.html. (in Persian).

نشریه علوم زیستی ورزشی
دوره 15، شماره 2 - شماره پیاپی 96
تیر 1402
صفحه 43-55
فایل ها
سابقه مقاله
  • تاریخ دریافت: 24 فروردین 1402
  • تاریخ بازنگری: 02 خرداد 1402
  • تاریخ پذیرش: 20 خرداد 1402
هم رسانی
ارجاع به این مقاله
آمار