نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 نویسندۀ مسؤول، گروه تربیت بدنی و علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه کاشان، کاشان، ایران.

2 گروه تربیت بدنی و علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه کاشان، کاشان، ایران.

چکیده

مقدمه: هدف تحقیق حاضر بررسی اثر تمرین با شدت بالا (HIIT) بر سطح سرمی لپتین افراد با و بدون بیماری‌های مزمن بود.
روش پژوهش: در این تحقیق از جست‌وجوی نظام‌مند در مقالات فارسی و انگلیسی منتشرشده تا دسامبر 2022، در پایگاه‌های اطلاعاتی وب آف ساینس، اسکاپوس، پابمد، مرکز جهاد دانشگاهی و مگیران با استفاده از کلیدواژه‌های مربوط استفاده شده است. پس از انتخاب مقالات موردنظر و بر اساس معیارهای ورود به تحقیق، فراتحلیل نتایج انجام گرفت. اندازۀ اثر (SMD) و فاصلۀ اطمینان 95 درصد، با استفاده از نرم‌افزار CMA2 محاسبه شد. برای بررسی ناهمگونی، از آزمون I2 و برای سوگیری انتشار از آزمون فونل پلات و تست Egger استفاده شد. تمامی تحلیل‌ها با استفاده نرم‌افزار CMA2 انجام گرفت.
یافته‌ها: نتایج تحلیل داده‌ها نشان داد که HIIT به کاهش معنا‌دار لپتین [008/0P= ،(07/0- تا 48/0CI: -) 28/0-] منجر شد. همچنین آنالیز داده‌های 9 مداخله نشان داد که تفاوت معنا‌داری بین HIIT و تمرین تداومی (MICT) بر مقادیر گردشی لپتین وجود نداشت [82/0P= ،(27/0 تا 34/0CI: -) 03/0-]. نتایج تحلیل زیرگروهی بر اساس وضعیت سلامتی آزمودنی‌ها نشان داد که HIIT به کاهش معنا‌دار لپتین در افراد با بیماری‌های مزمن منجر می‌شود.
بحث: HIIT به کاهش مقادیر گردش خونی لپتین، به‌ویژه در افراد با بیماری‌های مزمن منجر می‌شود. با وجود عدم تفاوت معنا‌دار بین HIIT و MICT، HIIT مداخلۀ مقرون به صرفه از لحاظ زمانی برای کاهش لپتین است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of High-Intensity Interval Training on Circulating Leptin Levels in Individuals With and Without Chronic Diseases: A Systematic Review and Meta-analysis

نویسندگان [English]

  • mohammad javad pourvaghar 1
  • Saeid Reza Noori Mofrad 2
  • Mousa Khalafi 2

1 University of kashan

2 Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.

چکیده [English]

Introduction: This study aimed to investigate the effect of High-Intensity Interval Training (HIIT) on serum leptin levels in individuals with and without chronic diseases.
Methods: In this research, a systematic search was conducted in Persian and English articles published until December 2022, in Web of Science, Scopus, PubMed, SID, and Magiran databases using relevant keywords. After selecting the desired articles based on the inclusion criteria, a meta-analysis of the results was performed. Effect size (SMD) and 95% confidence interval were calculated using CMA2 software. The I2 test was used to identify the heterogeneity, and for the publication bias, the Funnel Plot test and the Egger test were used. All analyzes were performed using CMA2 software.
Results: The results of data analysis showed that HIIT led to a significant decrease in serum leptin [-0.28 (CI: -0.07 to 0.48, p=0.008)]. Also, the data analysis of 9 interventions showed that there was no significant difference between HIIT and Medium Intensity Continuous Training (MICT) on circulating leptin levels [-0.03 (0.27 to 0.34 CI, p=0.82)]. The results of the subgroup analysis based on the health status of the subjects showed that HIIT resulted in a significant decrease in leptin in individuals with chronic diseases.
Conclusion: HIIT leads to a decrease in circulating leptin levels, especially in individuals with chronic diseases. Despite the lack of significant differences between HIIT and MICT, HIIT is a time-efficient intervention for leptin reduction.

کلیدواژه‌ها [English]

  • Continuous Training
  • Interval Training
  • Leptin
  • Obesity
  1. 1.De Oliveira Leal V, Mafra D. Adipokines in obesity. Clinica Chimica Acta. 2013;419:87-94. Doi.org/10.1016/j.cca.2013.02.003

    2.Maury E, Brichard S. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and cellular endocrinology. 2010; 314(1):1-16. Doi.org/10.1016/j.mce.2009.07.031

    3.Zhang F, Chen Y, Heiman M, DiMarchi R. Leptin: structure, function and biology. Vitamins & hormones. 2005; 71:345-72. Doi.org/10.1016/S0083-6729(05)71012-8

    4.Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clinica chimica acta. 2013; 417:80-4. Doi.org/10.1016/j.cca.2012.12.007

    5.Myers Jr MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends in Endocrinology & Metabolism. 2010;21(11):643-51. Doi.org/10.1016/j.tem.2010.08.002

    6.Laursen PB, Jenkins DG. The scientific basis for high-intensity interval training. Sports medicine. 2002; 32(1):53-73.

    7.Bahram ME, Pourvaghar MJ. The effect of 12 weeks of High-Intensity Interval Training (HIIT) on homocysteine and CRP cardiovascular risk factors and body composition in overweight men. Journal of Fasa University of Medical Sciences. 2016;6(3):334-42. [in persian]

    8.Khalafi M, Symonds ME. The impact of high intensity interval training on liver fat content in overweight or obese adults: A meta-analysis. Physiology & Behavior. 2021;236:113416. Doi.org/10.1016/j.physbeh.2021.113416

    9.Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Medicine. 2018;48(2):269-88.

    10.Kan C, Silva N, Golden SH, Rajala U, Timonen M, Stahl D, et al. A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes care. 2013;36(2):480-9.

    11.Bahram ME, Pourvaghar MJ. The Effect of 12 Weeks of High Intensive Intermittent Training on the Levels of Plasma Leptin, Insulin, Glucose, Insulin Resistance and Body Composition in Over-Weight Men. Medical Journal of Tabriz University of Medical Sciences. 2018;40(2):15-23. [in Persian]

    12.Khalafi M, Symonds ME. The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis. Scandinavian Journal of Medicine & Science in Sports. 2020;30(11):2020-36. Doi.org/10.1111/sms.13754

    13.Wewege M, Van Den Berg R, Ward R, Keech A. The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews. 2017;18(6):635-46. Doi.org/10.1111/obr.12532

    14.Aktaş H, Uzun Y, Kutlu O, Pençe H, Özçelik F, Çil E, et al. The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome. Archives of physiology and biochemistry. 2022;128(1):37-42. Doi.org/10.1080/13813455.2019.1662450

    15.Almenning I, Rieber-Mohn A, Lundgren KM, Shetelig Løvvik T, Garnaes KK, Moholdt T. Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: a pilot study. Plos one. 2015;10(9):e0138793. Doi.org/10.1371/journal.pone.0138793

    16.Avazpour S, Amini A. The effect of two high intensity interval training (HIIT) protocol on plasma levels of adiponectin, leptin and hypertension in overweight nurses. Iranian Journal of Cardiovascular Nursing. 2021; 10(1):102-9.

    17.Babaei Bonab S. The Effect of 12 Weeks of HIIT Training and Curcumin Consumption on Leptin and Galanin Levels in Obese Women. Journal of Ardabil University of Medical Sciences. 2020;20(2):188-99. [in Persian]

    18.Bahram ME, Pourrahim Ghouroghch A, Pourvaghar MJ, Ghyiami Taklimi H. Effect of 8-weeks High Intensity Interval Training on Adiponectin Plasma Level, Insulin, Insulin Resistance and Glucose in Overweight Young Men. Sport Physiology & Management Investigations. 2021;12(4):141-51. [in Persian]

    19.Blüher S, Käpplinger J, Herget S, Reichardt S, Böttcher Y, Grimm A, et al. Cardiometabolic risk markers, adipocyte fatty acid binding protein (aFABP) and the impact of high-intensity interval training (HIIT) in obese adolescents. Metabolism. 2017; 68:77-87. Doi.org/10.1016/j.metabol.2016.11.015

    20.Caldeira RS, Panissa VLG, Inoue DS, Campos EZ, Monteiro PA, de Melo Giglio B, et al. Impact to short-term high intensity intermittent training on different storages of body fat, leptin and soluble leptin receptor levels in physically active non-obese men: A pilot investigation. Clinical nutrition ESPEN. 2018; 28:186-92. Doi.org/10.1016/j.clnesp.2018.08.005

    21.Dünnwald T, Melmer A, Gatterer H, Salzmann K, Ebenbichler C, Burtscher M, et al. Supervised short-term high-intensity training on plasma irisin concentrations in type 2 diabetic patients. International journal of sports medicine. 2019;40(03):158-64. DOI: 10.1055/a-0828-8047

    22.Gerosa-Neto J, Panissa VLG, Monteiro PA, Inoue DS, Ribeiro JPJ, Figueiredo C, et al. High-or moderate-intensity training promotes change in cardiorespiratory fitness, but not visceral fat, in obese men: A randomised trial of equal energy expenditure exercise. Respiratory physiology & neurobiology. 2019; 266:150-5. Doi.org/10.1016/j.resp.2019.05.009

    23.Heiston EM, Eichner NZ, Gilbertson NM, Malin SK. Exercise improves adiposopathy, insulin sensitivity and metabolic syndrome severity independent of intensity. Experimental physiology. 2020; 105(4):632-40. Doi.org/10.1113/EP088158

    24.Hooshmand Moghadam B, Golestani F, Bagheri R, Cheraghloo N, Eskandari M, Wong A, et al. The effects of high-intensity interval training vs. moderate-intensity continuous training on inflammatory markers, body composition, and physical fitness in overweight/obese survivors of breast cancer: a randomized controlled clinical trial. Cancers. 2021;13(17):4386. Doi.org/10.3390/cancers13174386

    25.Khanvari T, Vakili J, Sari Sarraf V. Effect of High-Intensity Interval Training on Leptin, Adiponectin, and Leptin/Adiponectin Ratio in Overweight Adolescent Boys. Yafteh. 2021; 23(3). [in persian]

    26.Kong Z, Sun S, Liu M, Shi Q. Short-term high-intensity interval training on body composition and blood glucose in overweight and obese young women. Journal of diabetes research. 2016; 2016. Doi.org/10.1155/2016/4073618

    27.Kozłowska-Flis M, Rodziewicz-Flis E, Micielska K, Kortas J, Jaworska J, Borkowska A, et al. Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects. Frontiers in Bioscience-Landmark. 2021; 26(11):1132-46. Doi.org/10.52586/5015

    28.Lee SS, Yoo JH, So YS. Effect of the low-versus high-intensity exercise training on endoplasmic reticulum stress and GLP-1 in adolescents with type 2 diabetes mellitus. Journal of physical therapy science. 2015;27(10):3063-8. Doi: 10.1589/jpts.27.3063

    29.Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology. 2012;112(8):1353-60.Doi.org/10.1152/japplphysiol.01080.2011

    30.Madsen SM, Thorup AC, Bjerre M, Jeppesen PB. Does 8 weeks of strenuous bicycle exercise improve diabetes-related inflammatory cytokines and free fatty acids in type 2 diabetes patients and individuals at high-risk of metabolic syndrome? Archives of physiology and biochemistry. 2015; 121(4):129-38.Doi.org/10.3109/13813455.2015.1082600

    31.Malekinezhad H, Moflehi D, Abbasi H, Behzadi A. Effect of low or high volume of high-intensity interval training protocols on the leptin and lipid profile in men with type 2 diabetes. Journal of Community Health Research. 2019;8(4):228-36. Doi.org/10.18502/jchr.v8i4.2078.

    32.Middelbeek RJ, Motiani P, Brandt N, Nigro P, Zheng J, Virtanen KA, et al. Exercise intensity regulates cytokine and klotho responses in men. Nutrition & Diabetes. 2021;11(1):1-11.

    33.Rezaee Shirazi R. Effects of 12 weeks high intensity interval training on plasma Adiponectin, Leptin and insulin resistance in obese males with non-alcoholic fatty liver. Metabolism and Exercise. 2015; 5(1):23-34. [in Persian]

    34.TARTIBAIN B, SHARIFI H, EBRAHEMI TB. The effect of 12-week high-intensity interval training (HIIT) on lung function, serum leptin level and lipid profiles in inactive obese men. 2016. [in Persian]

    35.Azar JT, Hemmatinafar M, Nemati J. Effect of six weeks of high intensity interval training on leptin levels, lipid profile and fat percentage in sedentary young men. Sport Sci. 2018; 11(1):78-82. [in Persian]

    36.Khalafi M, Malandish A, Rosenkranz SK, Ravasi AA. Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta‐analysis. Obesity Reviews. 2021; 22(9):e13275. Doi.org/10.1111/obr.13275

    37.Khalafi M, Sakhaei MH, Kheradmand S, Symonds ME, Rosenkranz SK. The impact of exercise and dietary interventions on circulating leptin and adiponectin in individuals with overweight and obesity: a systematic review and meta-analysis. Advances in Nutrition. 2022. Doi.org/10.1016/j.advnut.2022.10.001

    38.Costa EC, Hay JL, Kehler DS, Boreskie KF, Arora RC, Umpierre D, et al. Effects of high-intensity interval training versus moderate-intensity continuous training on blood pressure in adults with pre-to established hypertension: a systematic review and meta-analysis of randomized trials. Sports Medicine. 2018; 48(9):2127-42.

    39.Lau PW, Kong Z, Choi C-r, Clare C, Chan DF, Sung RY, et al. Effects of short-term resistance training on serum leptin levels in obese adolescents. Journal of Exercise Science & Fitness. 2010; 8(1):54-60. Doi.org/10.1016/S1728-869X(10)60008-1

    40.Peng J, Yin L, Wang X. Central and peripheral leptin resistance in obesity and improvements of exercise. Hormones and Behavior. 2021; 133:105006. Doi.org/10.1016/j.yhbeh.2021.105006

    41.Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. British journal of sports medicine. 2010; 44(9):620-30.Doi.org/10.1136/bjsm.2008.046151

    1. Khalafi M, Mojtahedi S, Ostovar A, Rosenkranz SK, Korivi M. High‐intensity interval exercise versus moderate‐intensity continuous exercise on postprandial glucose and insulin responses: A systematic review and meta‐analysis. Obesity Reviews. 2022;23(8):e13459. Doi.org/10.1111/obr.13459
    2. Khalafi M, Ravasi AA, Malandish A, Rosenkranz SK. The impact of high-intensity interval training on postprandial glucose and insulin: A systematic review and meta-analysis. Diabetes Research and Clinical Practice. 2022:109815. Doi.org/10.1016/j.diabres.2022.109815

    44.Su L, Fu J, Sun S, Zhao G, Cheng W, Dou C, et al. Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis. PloS one. 2019;14(1):e0210644. Doi.org/10.1371/journal.pone.0210644