نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
نویسندگان
1 گروه فیزیولوژی ورزشی، دانشکدۀ علوم انسانی، مؤسسه آموزش عالی عمران و توسعه، همدان، ایران
2 نویسندۀ مسؤول، فیزیولوژی ورزشی، دانشکدۀ علوم انسانی، مؤسسه آموزش عالی عمران و توسعه، همدان، ایران.
3 گروه فیزیولوژی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه بوعلی سینا، همدان، ایران.
چکیده
سابقه و هدف: بیماری آلزایمر یک بیماری زوال عصبی است. تحقیق حاضر به منظور بررسی اثر دوازده هفته تمرین مقاومتی به همراه مصرف زالزالک بر برخی از شاخص‌های استرس اکسیداتیو در سرم موش‌های نر آلزایمری انجام گرفت.
روش کار: در این پژوهش30 سر موش صحرایی نر نژاد ویستار به شکل تصادفی در پنج گروه شش‌تایی؛ کنترل سالم، کنترل آلزایمری، آلزایمری نحت تمرین مقاومتی، آلزایمری تحت تمرین مقاومتی با مصرف زالزالک و آلزایمری به همراه مصرف زالزالک تقسیم شدند. تمرینات به مدت 12 هفته و 5 روز در هفته بصورت بالا رفتن از نردبانی به طول یک متر، همراه با وزنه‌های متصل به دم موش‌ها بود. وزنه متصل به دم هر حیوان در هفته اول 50 تا60 درصد و در هفته‌های پایانی به 140تا150درصد وزن موش‌ها رسید. گروه دریافت مکمل، مخلوط پودر زالزالک را با غذای استاندارد موش‌ها به نسبت 25/6 درصد پودر زالزالک دریافت می‌کردند. 24 ساعت بعد از آخرین مداخله تمرین و مکمل، موش‌ها بی‌هوش شدند و سطوح سرمی SOD، GPX، TAC و MAD به روش الایزر تعیین شد.
نتایج: نتایج نشان داد، تمرین مقاومتی به ویژه در زمان مصرف زالزالک، منجر به افزایش معنا دار (P = 0.002) سطح سرمی گلوتاتیون پراکسیداز در مقایسه با گروه های دیگر شد. اما تغییر معنا داری در سطح سرمی آنزیم سوپر اکسید دیسموتاز، ظرفیت.آنتی اکسیدانی تام و پراکسیداسیون لیپیدی در گروه‌های تجربی و کنترل دیده نشد.
نتیجه گیری: امکان دارد تمرین قدرتی و مکمل دهی با زالزالک در درمان جانبی در بیماران آلزایمری، به ویژه در مراحل اولیه موثر باشد.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The effect of resistance training with hawthorn consumption on some indicators of serum oxidative stress in male Alzheimer's mice.
نویسندگان [English]
- Samaneh Paknia 1
- Mohammad Ali Samavati Sharif 2
- Ali Heidarianpour 3
1 Department of Sports Physiology, Faculty of Humanities, University College of Omran_Toseeh, Hamedan, Iran
2 Corresponding Author, Department of Sports Physiology. Faculty of Humanities, University College of Omran_Toseeh, Hamedan, Iran
3 Department of Sports Physiology, Faculty of Sports Sciences, Bu Ali Sina University. Hamedan, Iran.
چکیده [English]
Background and purpose: Alzheimer's disease is a neurodegenerative disease. The present study was conducted to investigate the effect of twelve weeks of resistance training along with hawthorn consumption on some oxidative stress indicators in the serum of Alzheimer's male rats.
methods: In this study, 30 male Wistar rats were randomly divided into five groups of six. Healthy control, Alzheimer's control, Alzheimer's disease under resistance training, Alzheimer's disease under resistance training with hawthorn consumption, and Alzheimer's disease with hawthorn consumption were divided. Training was for 12 weeks and 5 days a week in the form of climbing a one-meter long ladder with weights attached to the rats' tails.The weight attached to the tail of each animal reached 50-60%in the first week and140-150%of the mice's weight in the last weeks.The group receiving the supplement received the mixture of hawthorn powder with the standard food of mice at a ratio of6.25%of hawthorn powder.24 hours after the last civilizing and supplemental intervention,the mice were unconscious and the serum levels of SOD,GPX,TACand MAD were determined by Eliezer method.Results:The results showed that resistance training, especially when taking hawthorn, led to a significant increase (P=0.002) in the serum level of glutathione peroxidase compared to other groups. However, no significant change was observed in the serum level of superoxide dismutase enzyme, total antioxidant capacity and lipid peroxidation in the experimental and control groups.
Conclusion: It is possible that resistance training and supplementation with hawthorn can be effective in adjunctive treatment in Alzheimer's patients, especially in the early stages.
کلیدواژه‌ها [English]
- Alzheimer'
- s rats
- resistance training
- hawthorn
- serum oxidative stress indicators
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- Serrano-Pozo A, Frosch M P, Masliah E, and HymanB T. Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine 2011 September ;(2)1:1-2.
- Liu Y, Yang L, Conde-Knape K, Beher D, Shearman MS, Shachter NS. Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells. Journal of lipid research 2004 December ;45(12): 2368-76.
- Wojsiat J , Zoltowska K M , Laskowska-Kaszub K , and Wojda U. Oxidant.Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects. Oxidative Medicine and Cellular Longevity 2018 January ;1(13):1-16.
- Zhu Y,*Lin Z, and Nakhleh L, A Network Perspective on Whole-Genome Duplication. G3 Genes|Genomes|Genetics 2013 November ;3(11):2049–2057.
- Huang Y, Yu J, Lanzi A, Yao X, Andrews C A, Tsai L, Gajjar M R, Sun M, Seaman M S, Padte N N, and Ho D D. Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity. National library of medicine 2016 June ;165(7):1621-1631.
- 7. Subapriya R and Rajesh A. Natural products and colon cancer: current status and future prospects. NIH Public Access 2008 Nov 1;69(7):460–471.
- 8. Adiele LC, Adiele RC, Enye JC. Wound healing effect of methanolic leaf extract of Napoleona vogelii (Family: Lecythidaceae) in rats. Asian Pacific journal of tropical medicine 2014 August ;7(8):620-4.
- Shapiro K, Gong WC. Natural products used for diabetes. Journal of the American
Pharmaceutical Association (1996) 2002 April;42(2):217-26.
- Chang Q. Zuo Z, Harrison F and Chow M S S. 'Hawthorn', The Journal of Clinical Pharmacology 2002 June;42(6):605-612.
- Zhang DL, Zhang YT, Yin JJ, Zhao BL. Oral administration of Crataegus flavonoids protects against ischemia. reperfusion brain damage in gerbils. J Neurochem 2004 July;90(1):211-219.
- Ahmadi Kakavandi M, Azizbeigi K, Gheissari F. Journal of the School of Paramedical Sciences, Tehran University of Medical Sciences (Payavard Salamat) 2019 June and July; 13(2):151-159
- Stanojevic D, Jakovljevic V, Barudzic N, Zivkovic V, Srejovic I, Parezanovic Ilic K, Cubrilo D, Ahmetovic Z, Peric D, Rosic M, Radovanovic D, Djordjevic D. Overtraining does not induce oxidative stress and inflammation in blood and heart of rats. National library of medicine 2016 November ;65:81-90.
- Mazlum Z, Mazidi M, Karimi E, Emami M. Antidiabetic effects of hawthorn aerial parts on lipids, blood glucose, and oxidative stress indices in diabetic rats. Journal of Mazandaran University of Medical Sciences 2013 December ;23(107):47-39.
- Tahvili F, Ahmadi M. The effect of endurance training with saffron extract on plasma levels of interleukin 17 and 18 in Alzheimer's mice by trimethyltin chloride. Journal of Complementary Medicine 2020 September;10(2):148-159.
- Ghasem Nia A A, Dighmi Z, Hadi S. The effect of eight weeks of incremental aerobic exercise with zinc supplementation on muscle superoxide dismutase activity and serum leptin levels and weight changes in adult male Wistar rats. Armaghan Danesh magazine 2018 February and March; 24(6):1054-1072.
- Nameni F, Ali Akbar Alavi R. The Effect of Hydroethanolic Extract of Pomegranate Peels and High-intense Interval Training on C-reactive Protein, Catalase and Superoxide Dismutase in Rats. Quarterly of Horizon of Medical Sciences 2021 March; 27(2): 182-197.
- Ghabezi S, Khajehlandi A, Mohammadi A. The effect of endurance training and crocin consumption on serum levels of glutathione peroxidase enzymes in ovarian female rats. Applied studies of life sciences in sports 2021 March; 17(9): 20-31.
- Mohammadi I, Nikosresht F. The effect of 8 weeks of increasing endurance training on superoxide dismutase enzyme activity and malondialdehyde levels in heart tissue of type 2 diabetic rats. Iranian Journal of Diabetes and Metabolism 2020 July; 28(3): 2490-2501.
- Vasali Akbarpour L, Samvati Sharif M A, Heydarianpour A. The Effects Of Endurance Swimming Plus Vitamin C Supplement On The Indices Of Oxidative Stress Among Male Rats. Scientific Research Journal of Ilam University of Medical Sciences 2017 February; 24(6):1-10.
- 21. Yousefpour M, Ghasem Nian A, Rahmani The effect of an intense interval training course on total antioxidant capacity and malondialdehyde in liver tissue of male Wistar rats. Scientific Journal of Kurdistan University of Medical Sciences 2015 August; 22(5):103-110.
- Hosni M, Behpour N, Karimi M, Darabi F. The Effect Of Allium Sativum With Four Weeks Of Incremental Training On The Response Of Some Oxidative Factors To A Single Session Of Acute Exercise In Well-Trained Wrestlers. Razi Volume Journal of Medical Sciences 2020 July; 27(4): 131-1.
- Helalizadeh M, Hatami E, Labbafi M R, Rouhani H, Haji Aghaei R. The effect of ginger medicinal plant on lipid peroxidation caused by sports activities. Quarterly Journal of Medicinal Plants 2020 August; 2(1): 38-42.
- De-Liang Z, Yue-Ting Z, Jun-Jie Y, Bao-Lu Z. Oral administration of Crataegus flavonoids protects against ischemia. reperfusion brain damage in gerbils. J Neurochem 2004 July; 90(1): 211-219.
- Lina T V, Tsaia S F and Kuoa V M. Physical Exercise Enhances Neuroplasticity and Delays Alzheimer’s Disease. National library of medicinenational library of medicine 2018 December; 4(1): 95-110.
- Yousefpour M, Ghasem Nian A A, Rahmani A. The effect of a period of high intensive interval training on total antioxidant capacity and level of liver tissue malondialdehyde in male wistar rats. Scientific Journal of Kurdistan University of Medical Sciences 2018 December; 22(1):103-110.
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