تاثیر تمرین مقاومتی سبک بر بیان ژن ABCA 1 در سلولهای لنفوسیت ومیزان HDL و LDL در گردش بیماران مرد عروق کرونر

حاجی قاسمی, علیرضا; رواسی, علی اصغر; کردی, محمدرضا; رشیدلمیر, امیر

doi:10.22059/jsb.2022.206134.1075

نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

¹ گروه فیزیولوژی ورزش، پردیس البرز، دانشگاه تهران، تهران،

² نویسنده مسئول، گروه فیزیولوژی ورزش، دانشکدة تربیت بدنی، دانشگاه تهران، تهران،ایران.

³ گروه فیزیولوژی ورزش، دانشکدة تربیت بدنی، دانشگاه تهران، تهران، ایران دانشیار.

⁴ گروه فیزیولوژی ورزشی، دانشکدة تربیت بدنی، دانشگاه فردوسی، مشهد، ایران.

https://doi.org/10.22059/jsb.2022.206134.1075

چکیده

مقدمه: یکی از مهم‌ترین علل پیدایش بیماری‌های قلبی- عروقی تصلب شرایین است. تصلب شرایین یا اترواسکروزیس نام یک بیماری در سیستم عروقی به‌خصوص در عروق کرونر مغز و قلب است که بر اثر رسوب لیپید و مواد دیگر روی دیوارة داخلی رگ‌ها مشخص می‌شود. اترواسکروز مهم‌ترین عامل مرگ‌ومیر در دنیاست. ABCA1 مسئول اصلی خروج کلسترول و فسفولیپید از سلول و تشکیل ذرات HDL است و احتمالاً در پیشگیری و جلوگیری از گسترش اترواسکلروزیس نقش دارد. هدف از تحقیق حاضر بررسی تأثیر تمرین بازتوانی قلبی بر بیان ژن ABCA1 باشد.
روش پژوهش: 23 نفر از بیماران گرفتگی عروق قلبی انتخاب و به‌صورت تصادفی به دو گروه کنترل (11نفر) و تجربی (12نفر) تقسیم شدند. گروه تجربی به مدت هشت هفته، هفته‌ای سه جلسة یک‌ساعته تمرینات مقاومتی سبک انجام دادند. پیش و پس از تمرینات مقدار m-RNA به روش PCR اندازه‌گیری شد. اطلاعات به‌وسیلة تحلیل کوواریانس تجزیه‌وتحلیل شد.
یافته‌ها: تمرینات بازتوانی موجب افزایش بیان ژنABCA1 و عدم تغییر HDL و LDL و نسبت RF شده است (P≤0.05).
نتیجه‌گیری: در پایان نتایج نشان داد تمرینات بازتوانی قلبی که از تمرینات هوازی و مقاومتی سبک تشکیل شده بود، در بیماران با گرفتگی عروق با وجود شدت پایین تمرینات سبب افزایش معنا‌دار در بیان ژن ABCA1 در بیماران گرفتگی عروق پس از هشت هفته شد که احتمالاً می‌تواند در انتقال معکوس کلسترول و پیشگیری از وقوع ایسکمی‌های بعدی مؤثر باشد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Moderate Resistance Training on Lymphocyte Cells ABCA1 Gene Expression, HDL and LDL in male with Coronary Artery Disease

نویسندگان [English]

Alireza Hajighasemi ¹
Ali Asghar Ravasi ²
Mohammad Reza Kordi ³
Amir Rashidlamir ⁴

¹ Department of Sport Biosciences, Alborz campus, Tehran University, Tehran, Iran.

² Corresponding Author, Department of Sport Biosciences, Faculty of Physical Education and Sport Sciences, University of Tehran,

³ Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.

⁴ Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.

چکیده [English]

Introduction: : One of the most important causes of cardiovascular diseases is atherosclerosis. Arteriosclerosis or atherosclerosis is the name of a disease in the vascular system, especially in the coronary arteries of the brain and heart, which is characterized by the deposition of lipids and other substances on the inner wall of the vessels. Atherosclerosis is the most important cause of death in the world. ABCA1 is the main responsible for the removal of cholesterol and phospholipid from the cell and the formation of HDL particles, and probably plays a role in the prevention and prevention of the spread of atherosclerosis. The aim of this study is the effect of cardiac rehabilitation training on ABCA1 gene expression.
Methods: Twentythree Myocardial infractions patients were randomly selected and assigned into two groups: control (N=11), and experimental (N=12). Blood sample of subjects were collected before and after exercise sessions. PBMN cells were separated and m-RNA purification was performed by Real–Time PCR. Data was analyzed by ANCOVA by SPSS software.
Results: Rehabilitation exercises increased ABCA1 gene expression and did not change HDL, LDL and RF ratio(P≤0.05).
Conclusion: In the end, the results of the research showed that cardiac rehabilitation exercises, which consisted of aerobic and light resistance exercises, in patients with arteriosclerosis, low intensity exercises caused a significant increase in ABCA1 gene expression in arteriosclerosis patients after 8 weeks, which probably It can be effective in reverse transfer of cholesterol and prevention of subsequent ischemia.

کلیدواژه‌ها [English]

ABCA1 gene
MI Gene
PBMN Gene
Resistance Exercise
Reverse Cholesterol Transport

مراجع

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[4]. Masuda D, Yamashita S. Very high levels of high-density lipoprotein cholesterol and cardiovascular events in Japanese population. Journal of Atherosclerosis and Thrombosis. 2016;23(7):771-2.

[5]. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[6]. Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports medicine. 2001;31:1033-62.

[7]. Yvan-Charvet L, Wang N, Tall AR. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arteriosclerosis, thrombosis, and vascular biology. 2010;30(2):139-43.

[8]. An F, Liu C, Wang X, Li T, Fu H, Bao B, et al. Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation. BMC Cardiovascular Disorders. 2021;21(1):78.

[9]. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, et al. ABCA1 and ABCG1 protect against oxidative stress–induced macrophage apoptosis during efferocytosis. Circulation research. 2010;106(12):1861-9.

[10]. Gelissen IC, Harris M, Rye K-A, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[11]. Ganjkhani L, Osali A. The Effect of 4 Week Resistance Training on Male Rat Hepatic ABCA1 Protein Plasma HDL-C Levels. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):22-30. [In Persian].

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[14]. Rashidlamir A, Dastani M, Saadatnia A, Bassami MR. Effect of cardiac rehabilitation training on ABCA1 expression in lymphocytes of patients undergoing coronary artery bypass graft operation. Zahedan Journal of Research in Medical Sciences. 2018;20(6). [In Persian].

[15]. Hoang A, Tefft C, Duffy SJ, Formosa M, Henstridge DC, Kingwell BA, et al. ABCA1 expression in humans is associated with physical activity and alcohol consumption. Atherosclerosis. 2008;197(1):197-203.

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[18]. Rashidlamir A, Dorrudi S, Ebrahimiatri A. The Effect of One Session of Aerobic and Resistance Exercise on Lymphocyte ABCA1 Gene Expression in Well–Trained Girls. Journal of Sport Biosciences. 2012;4(12):5-22. [In Persian].

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[21]. Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training. Journal of applied physiology. 2007;103(5):1655-61.

[22]. Rashidlamir A, Ghanbari-Niaki A, Saadatnia A. The Effect of eight weeks of wrestling and wrestling technique based circuit training on lymphocyte ABCA1 gene expression and plasma apolipoprotein AI. World J Sport Sci. 2011;2(2):144-50. [In Persian].

[23]. Ghorbanian B, Ravassi A, Kordi MR, Hedayati M. The effects of rope training on lymphocyte ABCA1 expression, plasma ApoA-I and HDL-c in boy adolescents. International journal of endocrinology and metabolism. 2013;11(2):76. [In Persian].

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[28]. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. methods. 2001;25(4):402-8.

[29]. Sazegar M, Rashid Lamir A, Khajei R, Barjeste Yazdi A. Effect of a Combined Exercise Program on the Expression of ABCA5 Gene in White Blood Cells of Middle-aged Men After Coronary Artery Bypass Graft Surgery. Internal Medicine Today. 2021;28(1):86-97.

[30]. Wang J, Xiao Q, Wang L, Wang Y, Wang D, Ding H. Role of ABCA1 in Cardiovascular Disease. Journal of Personalized Medicine. 2022;12(6):1010.

[31]. Büttner P, Mosig S, Lechtermann A, Funke H, Mooren FC. Exercise affects the gene expression profiles of human white blood cells. Journal of applied physiology. 2007;102(1):26-36.

[32]. Demina E, Miroshnikova V, Rodygina T, Kurianov P, Vinogradov A, Denisenko A, et al. ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis. Molecular Biology. 2011;45:258-62.

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[35]. Ghorbanian B, Kordi MR, Ravasi AA, Hedayati M, Ghasemnian AA. The Effects of Eight weeks Interval Endurance Training on Lymphocyte ABCA1 protein Expression, Plasma Apolipoprotein AI and Lipid Profiles in Overweight and Obese Boy Adolescents. Journal of Sport Biosciences. 2015;7(3):375-90.

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[37]. Fievet C, Castro G, James ER, Hennuyer N, Clee SM, Bissada N, et al. Increased ABCA1 activity protects against atherosclerosis. The Journal of clinical investigation. 2002;110(1):35-42.

[38]. Jamali FS, Rashidlamir A, Attarzadeh Hosseini SR. Effects of Combined aerobic and resistance Exercise on miR-93, Reverse Cholesterol Transport and Serum Leptin Levels in Patients After Coronary Artery Bypass Graft Surgery. Journal of Mazandaran University of Medical Sciences. 2023;33(221):12-22. [In Persian].

نشریه علوم زیستی ورزشی

تاثیر تمرین مقاومتی سبک بر بیان ژن ABCA 1 در سلولهای لنفوسیت ومیزان HDL و LDL در گردش بیماران مرد عروق کرونر

مراجع

مراجع

[1]. Jacobo-Albavera L, Domínguez-Pérez M, Medina-Leyte DJ, González-Garrido A, Villarreal-Molina T. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. International Journal of Molecular Sciences. 2021;22(4):1593.

[2]. Rashidlamir A. Investigation of the effect of aerobic and resistance exercises on peripheral blood mononuclear cells ABCG1 gene expression in female athletes. SSU_Journals. 2012;20(1):1-9. [In Persian].

[4]. Masuda D, Yamashita S. Very high levels of high-density lipoprotein cholesterol and cardiovascular events in Japanese population. Journal of Atherosclerosis and Thrombosis. 2016;23(7):771-2.

[5]. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[6]. Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports medicine. 2001;31:1033-62.

[7]. Yvan-Charvet L, Wang N, Tall AR. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arteriosclerosis, thrombosis, and vascular biology. 2010;30(2):139-43.

[8]. An F, Liu C, Wang X, Li T, Fu H, Bao B, et al. Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation. BMC Cardiovascular Disorders. 2021;21(1):78.

[9]. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, et al. ABCA1 and ABCG1 protect against oxidative stress–induced macrophage apoptosis during efferocytosis. Circulation research. 2010;106(12):1861-9.

[10]. Gelissen IC, Harris M, Rye K-A, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[11]. Ganjkhani L, Osali A. The Effect of 4 Week Resistance Training on Male Rat Hepatic ABCA1 Protein Plasma HDL-C Levels. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):22-30. [In Persian].

[12]. Ikenaga M, Higaki Y, Saku K, Uehara Y. High-density lipoprotein mimetics: a therapeutic tool for atherosclerotic diseases. Journal of Atherosclerosis and Thrombosis. 2016;23(4):385-94.

[14]. Rashidlamir A, Dastani M, Saadatnia A, Bassami MR. Effect of cardiac rehabilitation training on ABCA1 expression in lymphocytes of patients undergoing coronary artery bypass graft operation. Zahedan Journal of Research in Medical Sciences. 2018;20(6). [In Persian].

[15]. Hoang A, Tefft C, Duffy SJ, Formosa M, Henstridge DC, Kingwell BA, et al. ABCA1 expression in humans is associated with physical activity and alcohol consumption. Atherosclerosis. 2008;197(1):197-203.

[17]. Ghanbari-Niaki A, Saghebjoo M, Hedayati M. A single session of circuit-resistance exercise effects on human peripheral blood lymphocyte ABCA1 expression and plasma HDL-C level. Regulatory peptides. 2011;166(1-3):42-7. [In Persian].

[18]. Rashidlamir A, Dorrudi S, Ebrahimiatri A. The Effect of One Session of Aerobic and Resistance Exercise on Lymphocyte ABCA1 Gene Expression in Well–Trained Girls. Journal of Sport Biosciences. 2012;4(12):5-22. [In Persian].

[21]. Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training. Journal of applied physiology. 2007;103(5):1655-61.

[22]. Rashidlamir A, Ghanbari-Niaki A, Saadatnia A. The Effect of eight weeks of wrestling and wrestling technique based circuit training on lymphocyte ABCA1 gene expression and plasma apolipoprotein AI. World J Sport Sci. 2011;2(2):144-50. [In Persian].

[23]. Ghorbanian B, Ravassi A, Kordi MR, Hedayati M. The effects of rope training on lymphocyte ABCA1 expression, plasma ApoA-I and HDL-c in boy adolescents. International journal of endocrinology and metabolism. 2013;11(2):76. [In Persian].

[24]. Mostafavi S, Saeidi M, Heidari H. Effects of a comprehensive cardiac rehabilitation program on the quality of life of patients with cardio-vascular diseases. Journal of Research in Rehabilitation Sciences. 2012;7(4). [In Persian].

[25]. Borg GA. Physical performance and perceived exertion. 1962.

[28]. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. methods. 2001;25(4):402-8.

[29]. Sazegar M, Rashid Lamir A, Khajei R, Barjeste Yazdi A. Effect of a Combined Exercise Program on the Expression of ABCA5 Gene in White Blood Cells of Middle-aged Men After Coronary Artery Bypass Graft Surgery. Internal Medicine Today. 2021;28(1):86-97.

[30]. Wang J, Xiao Q, Wang L, Wang Y, Wang D, Ding H. Role of ABCA1 in Cardiovascular Disease. Journal of Personalized Medicine. 2022;12(6):1010.

[31]. Büttner P, Mosig S, Lechtermann A, Funke H, Mooren FC. Exercise affects the gene expression profiles of human white blood cells. Journal of applied physiology. 2007;102(1):26-36.

[32]. Demina E, Miroshnikova V, Rodygina T, Kurianov P, Vinogradov A, Denisenko A, et al. ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis. Molecular Biology. 2011;45:258-62.

[34]. Ghanbari-Niaki A. Treadmill exercise training enhances ATP-binding cassette protein-A1 (ABCA1) expression in male rats’ heart and gastrocnemius muscles. Int J Endocrinol Metab. 2010;8(4):206-10. [In Persian].

[35]. Ghorbanian B, Kordi MR, Ravasi AA, Hedayati M, Ghasemnian AA. The Effects of Eight weeks Interval Endurance Training on Lymphocyte ABCA1 protein Expression, Plasma Apolipoprotein AI and Lipid Profiles in Overweight and Obese Boy Adolescents. Journal of Sport Biosciences. 2015;7(3):375-90.

[36]. Von Eckardstein A, Nofer J-R, Assmann G. High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport. Arteriosclerosis, thrombosis, and vascular biology. 2001;21(1):13-27.

[37]. Fievet C, Castro G, James ER, Hennuyer N, Clee SM, Bissada N, et al. Increased ABCA1 activity protects against atherosclerosis. The Journal of clinical investigation. 2002;110(1):35-42.

دوره 16، شماره 1 - شماره پیاپی 99
فروردین 1403
صفحه 5-15

تاثیر تمرین مقاومتی سبک بر بیان ژن ABCA 1 در سلولهای لنفوسیت ومیزان HDL و LDL در گردش بیماران مرد عروق کرونر

مراجع

مراجع

[1]. Jacobo-Albavera L, Domínguez-Pérez M, Medina-Leyte DJ, González-Garrido A, Villarreal-Molina T. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. International Journal of Molecular Sciences. 2021;22(4):1593.

[2]. Rashidlamir A. Investigation of the effect of aerobic and resistance exercises on peripheral blood mononuclear cells ABCG1 gene expression in female athletes. SSU_Journals. 2012;20(1):1-9. [In Persian].

[4]. Masuda D, Yamashita S. Very high levels of high-density lipoprotein cholesterol and cardiovascular events in Japanese population. Journal of Atherosclerosis and Thrombosis. 2016;23(7):771-2.

[5]. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[6]. Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports medicine. 2001;31:1033-62.

[7]. Yvan-Charvet L, Wang N, Tall AR. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arteriosclerosis, thrombosis, and vascular biology. 2010;30(2):139-43.

[8]. An F, Liu C, Wang X, Li T, Fu H, Bao B, et al. Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation. BMC Cardiovascular Disorders. 2021;21(1):78.

[9]. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, et al. ABCA1 and ABCG1 protect against oxidative stress–induced macrophage apoptosis during efferocytosis. Circulation research. 2010;106(12):1861-9.

[10]. Gelissen IC, Harris M, Rye K-A, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[11]. Ganjkhani L, Osali A. The Effect of 4 Week Resistance Training on Male Rat Hepatic ABCA1 Protein Plasma HDL-C Levels. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):22-30. [In Persian].

[12]. Ikenaga M, Higaki Y, Saku K, Uehara Y. High-density lipoprotein mimetics: a therapeutic tool for atherosclerotic diseases. Journal of Atherosclerosis and Thrombosis. 2016;23(4):385-94.

[14]. Rashidlamir A, Dastani M, Saadatnia A, Bassami MR. Effect of cardiac rehabilitation training on ABCA1 expression in lymphocytes of patients undergoing coronary artery bypass graft operation. Zahedan Journal of Research in Medical Sciences. 2018;20(6). [In Persian].

[15]. Hoang A, Tefft C, Duffy SJ, Formosa M, Henstridge DC, Kingwell BA, et al. ABCA1 expression in humans is associated with physical activity and alcohol consumption. Atherosclerosis. 2008;197(1):197-203.

[17]. Ghanbari-Niaki A, Saghebjoo M, Hedayati M. A single session of circuit-resistance exercise effects on human peripheral blood lymphocyte ABCA1 expression and plasma HDL-C level. Regulatory peptides. 2011;166(1-3):42-7. [In Persian].

[18]. Rashidlamir A, Dorrudi S, Ebrahimiatri A. The Effect of One Session of Aerobic and Resistance Exercise on Lymphocyte ABCA1 Gene Expression in Well–Trained Girls. Journal of Sport Biosciences. 2012;4(12):5-22. [In Persian].

[21]. Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training. Journal of applied physiology. 2007;103(5):1655-61.

[22]. Rashidlamir A, Ghanbari-Niaki A, Saadatnia A. The Effect of eight weeks of wrestling and wrestling technique based circuit training on lymphocyte ABCA1 gene expression and plasma apolipoprotein AI. World J Sport Sci. 2011;2(2):144-50. [In Persian].

[23]. Ghorbanian B, Ravassi A, Kordi MR, Hedayati M. The effects of rope training on lymphocyte ABCA1 expression, plasma ApoA-I and HDL-c in boy adolescents. International journal of endocrinology and metabolism. 2013;11(2):76. [In Persian].

[24]. Mostafavi S, Saeidi M, Heidari H. Effects of a comprehensive cardiac rehabilitation program on the quality of life of patients with cardio-vascular diseases. Journal of Research in Rehabilitation Sciences. 2012;7(4). [In Persian].

[25]. Borg GA. Physical performance and perceived exertion. 1962.

[28]. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. methods. 2001;25(4):402-8.

[29]. Sazegar M, Rashid Lamir A, Khajei R, Barjeste Yazdi A. Effect of a Combined Exercise Program on the Expression of ABCA5 Gene in White Blood Cells of Middle-aged Men After Coronary Artery Bypass Graft Surgery. Internal Medicine Today. 2021;28(1):86-97.

[30]. Wang J, Xiao Q, Wang L, Wang Y, Wang D, Ding H. Role of ABCA1 in Cardiovascular Disease. Journal of Personalized Medicine. 2022;12(6):1010.

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دوره 16، شماره 1 - شماره پیاپی 99فروردین 1403صفحه 5-15

دوره 16، شماره 1 - شماره پیاپی 99
فروردین 1403
صفحه 5-15