نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
نویسندگان
1 گروه فیزیولوژی ورزشی، واحد آیت االله آملی، دانشگاه آزاد اسلامی، آمل، ایران.
2 نویسندة مسئول : گروه فیزیولوژی ورزشی، واحد آیت االله آملی، دانشگاه آزاد اسلامی، آمل، ایران.
چکیده
استرس اکسیداتیو با انواع مختلفی از بیماری‌های التهابی و متابولیک از جمله چاقی ارتباط دارد. هدف این مطالعه برسی تاثیر هشت هفته تمرین هوازی و ژل رویال بر فشار اکسایشی و آنزیم‌های بافت کبدی موش‌های چاق بود. در این مطالعه تجربی، 45 سر موش صحرایی نر نژاد ویستار (میانگین وزن 37/9±5/187) در پنج گروه رژیم غذایی نرمال (ND)، رژیم غذایی پرچرب (HFD)، رژیم غذایی پرچرب-تمرین (HFDT)، رژیم غذایی پرچرب-ژل رویال (HFDRJ) و رژیم غذایی پرچرب-تمرین-ژل رویال (HFDTRJ) قرار گرفتند. گروه‌های مکمل، طی دوره مداخله روزانه 100 میلی‌گرم ژل رویال (به ازای هر کیلوگرم وزن بدن) رقیق شده در آب مقطر را به صورت خوراکی دریافت کردند. برنامه تمرین هوازی شامل دویدن روی تردمیل با شدت 60-50 درصد اکسیژن مصرفی (VO2max)، پنج روز هفته به مدت هشت هفته اجرا شد. داده‌ها به روش تحلیل واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معنی‌داری P<0.05 تجزیه و تحلیل شد. افزایش معنی‌دار در میزان MDA و کاهش معنی دار میزان SOD، GPX و CAT در گروه HFD نسبت به گروه ND مشاهده شد(001/0=P). همچنین کاهش معنی‌داری در مقادیر MDA افزایش معنی-دار میزان SOD، GPX و CAT در گروه‌های HFDT، HFDRJ و HFDTRJ نسبت به گروه HFD؛ و گروه HFDTRJ نسبت به گروه‌های HFDT، HFDRJ مشاهده شد (001/0=P). به‌نظر می‌رسد مداخله تمرین هوازی و ژل رویال می‌تواند به کاهش فشار اکسایشی و بهبود آنزیم‌های کبدی طی چاقی کمک کند.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The Effect of Eight Weeks of Aerobic Training and Royal Jelly on Oxidative Stress and Liver Tissue Enzymes in Obese Rats
نویسندگان [English]
- Ali Asghar Magholi 1
- Ahmad Abdi 2
- Asieh Abbasi daloii 1
1 Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2 Corresponding Author, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
چکیده [English]
Introduction: Oxidative stress is associated with a variety of inflammatory and metabolic diseases, including obesity. This study aimed to investigate the effect of eight weeks of aerobic training and Royal Jelly on oxidative stress and liver tissue enzymes of obese rats.
Methods: In this experimental study, 45 male Wistar rats (mean weight= 187.5±9.37 grams) were divided into 5 groups: Normal Diet (ND), High-Fat Diet (HFD), High-Fat Diet + Training (HFDT), High-Fat Diet + Royal Jelly (HFDRJ) and High-Fat Diet + Training + Royal Jelly (HFDTRJ). The supplement groups orally received 100 mg of royal jelly (per kg of body weight) diluted in distilled water during the intervention period. An aerobic training program including running on a treadmill with an intensity of 50-60% of oxygen consumption (VO2max), was performed Five days a week for eight weeks. Data were analyzed using a one-way analysis of variance and Tukey’s post hoc test at a significance level of α=0.05. Results: There was a significant increase in malondialdehyde (MDA) and a significant decrease in Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), and Catalase (CAT) in HFD group compared with ND group (P=0.001). Also, a significant decrease in MDA values and a significant increase in amounts of SOD, GPX, and CAT was observed in HFDT, HFDRJ, and HFDTRJ groups compared with the HFD group; and in the HFDTRJ group compared with HFDT and HFDRJ groups (P=0.001).
Conclusion: It seems that the intervention of aerobic training and royal jelly can help to reduce oxidative stress and improve liver enzymes during obesity.
کلیدواژه‌ها [English]
- Aerobic exercise
- Oxidant and antioxidant
- Liver tissue
- Obesity
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