نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی/دانشگاه ارومیه
2 دانشگاه ارومیه، دانشیار فیزیولوژی ورزشی
3 گروه علوم‌پایه، بخش بافت شناسی و جنین شناسی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران.
4 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
No clear effect of exercise training protocols has been identified on apoptosis induction and/or inhibition. Therefore, the current study was designed to examine the effects of continuous exercise training protocols with different intensities on apoptosis in testicular tissue of Wistar rats. For this purpose, 24 mature Wistar rats were randomly divided into control, low, moderate, and high-intensity continuous training groups. The VMAX%50-60, VMAX%65-70, and Vmax%80-85 were considered for low (LICT), moderate (MICT), and high (HICT)-intensity continuous exercise-induced groups. ANOVA was considered for statistical analyses and followed by Tukey test. The LICT and MICT groups showed no significant statistical changes in the Bcl-2, Bax, and caspase-3 expression levels compared to the control group (P>0.05). However, the HICT-induced groups exhibited a remarkable reduction in Bcl-2 (P= 0/01) and increment in the Bax and caspase-3 expression levels (P= 0/001). Additionally, the LICT and MICT groups exhibited no significant increases in apoptotic cells, whereas the HICT group represented a significant increment (P= 0/001). The results suggest that 8 weeks of LICT and MICT exercise protocols do not induce mitochondria-dependent apoptosis, whereas HICT by suppressing Bcl-2 expression levels and increasing Bax and caspase-3 expression levels promotes apoptosis induction and increases apoptotic cell numbers.
کلیدواژه‌ها [English]
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