رابطة بین سطوح سرمی سالوسین‌های آلفا و بتا با نیمرخ لیپیدی، مقاومت انسولینی و آمادگی قلبی تنفسی و اثر یک دوره تمرینات تناوبی با شدت‌های مختلف در زنان دارای اضافه وزن/چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه فیزیولوژی ورزشی، دانشکدة علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

2 دانشیار، گروه فیزیولوژی ورزشی، دانشکدة علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

3 استادیار، مرکز تحقیقات متابولیک کبد، مرکز آموزشی درمانی کودکان امام حسین (ع)، دانشگاه علوم پزشکی اصفهان، اصفهان،

چکیده

هدف پژوهش حاضر بررسی رابطة بین سطوح سرمی سالوسین‌ها با نیمرخ لیپیدی، مقاومت انسولینی آمادگی قلبی تنفسی، ترکیب بدنی و درصد چربی بدن متعاقب یک دوره تمرینات تناوبی منتخب با شدت‌های متفاوت در زنان دارای اضافه ‌وزن و چاق بود. در این مطالعه 40 زن غیرفعال در 3 گروه همگن به شکل هدفمند تقسیم شدند: کنترل (14=n ؛ kg/m28/2± 2/30=BMI)؛ تمرین تناوبی با شدت متوسط،80-75%ضربان قلب بیشینه (13=n ؛kg/m23/3±2/31=BMI) و تناوبی با شدت زیاد، 95-90%ضربان قلب بیشینه (13=n؛ kg/m24/3 ±19/30=BMI). آزمودنی‌های تجربی به مدت 8 هفته در تمرینات تناوبی رکاب زدن با شدت‌های مختلف شرکت داشتند. نمونه‌گیری خون به‌ترتیب به فاصلة 48 ساعت قبل از شروع اولین جلسة تمرینی و 48 ساعت پس از آخرین جلسة تمرینی انجام گرفت و متغیرهای تحقیق در شرایط یکسان اندازه‌گیری شدند. از آزمون‌ ضریب همبستگی پیرسون برای تحلیل آماری داده‌ها در ســطح 05/0P< استفاده شد. نتایج نشان داد که میان سطوح سالوسین بتا و کلسترول تام، سالوسین آلفا و HDL، سالوسین آلفا و آمادگی قلبی تنفسی آزمودنی‌ها ارتباط مثبت و معنادار، و میان سالوسین آلفا و درصد چربی بدن ارتباط معکوس و معناداری وجود دارد. به‌نظر می‌رسد تمرینات تناوبی با شدت‌های مختلف می‌توانند در بهبود آمادگی قلبی و سلامت عمومی افراد چاق مؤثر باشند. از آنجا که بین شدت تمرینات تناوبی و بهبود آمادگی قلبی تنفسی، مقاومت انسولینی و نیمرخ لیپیدی آزمودنی‌ها رابطة قابل توجهی وجود دارد، بنابراین انجام تمرینات تناوبی با شدت بالا برای توسعة تندرستی این گروه از افراد جامعه پیشنهاد می‌شود.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The Relationship between Serum Levels of Alpha and Beta Salusins and Lipid Profile, Insulin Resistance, Cardio-Respiratory Fitness and the Effect of Interval Training with Different Intensities in Overweight/Obese Women

نویسندگان [English]

  • Maryam Nazari 1
  • VAZGEN MINASIAN 2
  • Silva Hovsepian 3
1 Ph.D. Student, Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
2 Associate Professor, Department of Exercise physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
3 Assistant Professor, Metabolic Liver Disease Research Center, Imam Hossien Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

The aim of this study was to investigate the relationship between serum levels of salusins and lipid profile, insulin resistance, cardio-respiratory fitness, body composition and body fat percentage after a period of selected interval training with different intensities in overweight/obese women. In this study, 40 sedentary women were divided into 3 homogeneous groups purposively: control (BMI=30.2±2.8 kg/m2, n=14), moderate-intensity interval training: 75-80% HRmax (BMI=31.2±3.3 kg/m2, n=13), and high-intensity interval training: 90-95% HRmax (BMI=30.19±3.4 kg/m2, n=13). The subjects of experimental groups participated in the interval training (pedaling) with different intensities for 8 weeks. Blood samples were collected 48 hours before the first training session and 48 hours after the last training session. The research variables were measured under similar conditions. Pearson correlation coefficient test was used to statistically analyze the data (P<0.05). The findings revealed significant positive relationships between salusin β levels and total cholesterol, salusin α and HDL and salusin α and cardio-respiratory fitness; there was a significant reverse relationship between salusin α and body fat percentage. It seems that interval training with different intensities can influence the improvement of cardio fitness and general health of obese individuals. Since there is a considerable relationship between the intensity of interval training and the improvement of cardio-respiratory fitness, insulin resistance and lipid profile, high-intensity interval training is recommended to improve well-being of this group of people.

کلیدواژه‌ها [English]

  • Obesity
  • salusin α
  • salusin β
  • Training
1. Kopelman P. Health risks associated with overweight and obesity. Obesity reviews. 2007;8:13-7.
2. Williams I, Wheatcroft S, Shah A, Kearney M. Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. International journal of obesity. 2002;26(6):754-64.
3. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, et al. Multi-ethnic study of atherosclerosis: objectives and design. American journal of epidemiology. 2002;156(9):871-81.
4. Yu X-H, Fu Y-C, Zhang D-W, Yin K, Tang C-K. Foam cells in atherosclerosis. Clinica chimica acta. 2013;424:245-52.
5. Watanabe T, Nishio K, Kanome T, Matsuyama T-a, Koba S, Sakai T, et al. Impact of salusin-a and-b on human macrophage foam cell formation and coronary atherosclerosis. Circulation. 2008;117(5):638-48.
6. Shichiri M, Ishimaru S, Ota T, Nishikawa T, Isogai T, Hirata Y. Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nature medicine. 2003;9(9):66-72.
7. Wang Z, Takahashi T, Saito Y, Nagasaki H, Ly NK, Nothacker H-P, et al. Salusin β is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1. European journal of pharmacology. 2006;539(3):145-50.
8. Watanabe T, Nishio K, Kanome T, Matsuyama T-a, Koba S, Sakai T, et al. Impact of salusin-α and-β on human macrophage foam cell formation and coronary atherosclerosis. Circulation. 2008;117(5):638-48.
9. Masumura M, Watanabe R, Nagashima A, Ogawa M, Suzuki J-i, Shichiri M, et al. Anti-salusin-β antibody enhances angiogenesis after myocardial ischemia reperfusion injury. Expert opinion on therapeutic targets. 2013;17(9):1003-9.
10. Zhu X, Zhou Y, Cai W, Sun H, Qiu L. Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway. Biochemical and biophysical research communications. 2017;491(2):515-21.
11. Aronson D, Rayfield EJ. How hyperglycemia promotes atherosclerosis: molecular mechanisms. Cardiovascular diabetology. 2002;1(1):1.
12. Li N, Zheng Y-B, Han J, Liang W, Wang J-Y, Zhou J-R, et al. Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation. BMC musculoskeletal disorders. 2013;14(1):49.
13. Lichtenstein L, Kersten S. Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2010;1801(4):415-20.
14. Shoji T, Abe T, Matsuo H, Egusa G, Yamasaki Y, Kashihara N, et al. Chronic kidney disease, dyslipidemia, and atherosclerosis. Journal of atherosclerosis and thrombosis. 2012;19(4):299-315.
15. Racil GO, O Ben Hammouda, O Kallel, A Zouhal, H Chamari, K Amri, M. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. European journal of applied physiology. 2013;113(10):2531-40.
16. Nazari M, Minasian V, Hovsepian S. Effects of two types of moderate-and high-intensity interval training on serum salusin-α and Salusin-β levels and lipid profile in women with overweight/obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2020;13:1385.
17. Dalmazzo V, Ponce A, Delgado FP, Carrasco AV, Martínez SC. Effects of interval exercise in the improvement of glycemic control of obese adults with insulin resistance. Nutricion hospitalaria. 2019;36(3):578.
18. Grzegorzewska AE, Niepolski L, Sikora J, Janków M, Jagodzinski PP, Sowinska A. Effect of lifestyle changes and atorvastatin administration on dyslipidemia in hemodialysis patients: a prospective study. Pol Arch Med Wewn. 2014;124:443-51.
19. Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, et al. Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults. Aging (Albany NY). 2020;12(2):1201.
20. Eston R, Reilly T. Kinanthropometry and exercise physiology laboratory manual: tests, procedures and data: volume two: physiology: Routledge; 2013.
21. Ekblom‐Bak E, Björkman F, Hellenius ML, Ekblom B. A new submaximal cycle ergometer test for prediction of VO2max. Scandinavian journal of medicine & science in sports. 2014;24(2):319-26.
22. Dai C-Y, Huang J-F, Hsieh M-Y, Hou N-J, Lin Z-Y, Chen S-C, et al. Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic hepatitis C patients. Journal of hepatology. 2009;50(4):712-8.
23. Nagashima M, Watanabe T, Shiraishi Y, Morita R, Terasaki M, Arita S, et al. Chronic infusion of salusin-α and-β exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis. 2010;212(1):70-7.
24. Paahoo A, Tadibi V, Behpoor N. Effect of Two Chronic Exercise Protocols on Pre-Atherosclerotic and Anti-Atherosclerotic Biomarkers Levels in Obese and Overweight Children. Iranian Journal of Pediatrics. 2020;30 (2).
25. Black PH. The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain, behavior, and immunity. 2003;17(5):350-64.
26. Chung CP, Long AG, Solus JF, Rho YH, Oeser A, Raggi P, et al. Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis. Lupus. 2009;18(9):799-806.
27. Watanabe T, Suguro T, Sato K, Koyama T, Nagashima M, Kodate S, et al. Serum salusin-α levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients. Hypertension Research. 2008;31(3):463-8.
28. Vissers D, Hens W, Taeymans J, Baeyens J-P, Poortmans J, Van Gaal L. The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PloS one. 2013;8(2):e56415.
29. Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, et al. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical Journal. 1990;270(2):397-400.
30. Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra A-M. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. European journal of applied physiology. 2004;92(4-5):437-42.
31. Russomando L, Bono V, Mancini A, Terracciano A, Cozzolino F, Imperlini E, et al. The Effects of Short-Term High-Intensity Interval Training and Moderate Intensity Continuous Training on Body Fat Percentage, Abdominal Circumference, BMI and VO2max in Overweight Subjects. Journal of Functional Morphology and Kinesiology. 2020;5(2):41.
32. Khammassi M, Ouerghi N, Hadj-Taieb S, Feki M, Thivel D, Bouassida A. Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth. Journal of exercise rehabilitation. 2018;14(1):118.
33. Billat VL, Slawinski J, Bocquet V, Demarle A, Lafitte L, Chassaing P, et al. Intermittent runs at the velocity associated with maximal oxygen uptake enables subjects to remain at maximal oxygen uptake for a longer time than intense but submaximal runs. European journal of applied physiology. 2000;81(3):188-96.