نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
نویسندگان
1 دانشیار گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تبریز، تبریز، ایران
2 دانشجوی دورۀ دکتری فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تبریز،تبریز، ایران
چکیده
چاقی از مهم‌ترین چالش‌های بهداشت عمومی قرن حاضر است که سبب افزایش سطوح پلاسمایی سایتوکین‌های التهابی و کاهش عوامل ضدالتهابی و آنتی آتروژنیک می‌شود. احتمالاً تمرینات تناوبی با شدت بالا بتوانند این تأثیرات مخرب را متوقف یا معکوس کنند. ازاین‌رو هدف از مطالعۀ حاضر بررسی تأثیر 8 هفته تمرینات تناوبی بر عوامل التهابی پسران نوجوان دارای اضافه‌وزن است. در یک طرح تحقیقی نیمه‌تجربی از میان پسران نوجوان دارای اضافه‌وزن (18-13 سال، میانگین قد 33/154 سانتی‌متر، میانگین شاخص تودۀ بدنی 05/27 کیلوگرم بر متر مربع)، 30 نفر به‌صورت داوطلبانه در 3 گروه 10 نفره شامل گروه تمرین تناوبی کوتاه‌مدت (9 وهلۀ 30 ثانیه‌ای، 100تا 110 درصد حداکثر سرعت با 150 ثانیه استراحت)، طولانی‌مدت (4 وهلۀ 150 ثانیه‌ای، 90 تا 95 درصد حداکثر سرعت با 240 ثانیه استراحت) و گروه کنترل قرار گرفتند. 48 ساعت قبل از شروع و بعد از اتمام پروتکل ورزشی، وزن، قد، شاخص تودۀ بدنی و درصد چربی به‌وسیلۀ دستگاه تعیین ترکیب بدنی اندازه‌گیری و نمونه‌های خونی برای تعیین شاخص‌های اینترلوکین-6، اینترلوکین 10 و پروتئین واکنشی C اخذ شد. نتایج نشان داد 8 هفته تمرین تناوبی با شدت بالا موجب افزایش اینترلوکین 10 و کاهش پروتئین واکنشی C می‌شود. اما بر اینترلوکین-6 تأثیر معناداری ندارد. همچنین مشخص شد بین دو نوع تمرین کوتاه‌مدت و بلندمدت HIIT هیچ تفاوتی در تأثیرگذاری بر شاخص‌های مدنظر وجود ندارد. براساس یافته‌ها می‌توان گفت نوجوانان دارای اضافه‌وزن یا چاق احتمالاً بتوانند با استفاده از تمرینات HIIT سیستم ضدالتهابی خویش را با افزایش اینترلوکین-6 و کاهش پروتئین واکنشی C تقویت کنند. اما برای تعیین اثر این تمرینات بر اینترلوکین 6 به مطالعات بیشتری نیاز است.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The Effect of 8 Weeks of HIIT on Inflammatory Factors in Overweight Adolescent Boys
نویسندگان [English]
- Javad Vakilii 1
- Vahid Sari Saraf 1
- Tohid Khanvari 2
1 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
2 Ph.D. Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
چکیده [English]
Obesity is one of the most important public health challenges of the present century, which increases the plasma levels of inflammatory cytokines and decreases anti-inflammatory and anti-atherogenic agents. High intensity interval training may be able to stop or reverse these destructive effects. Therefore, the aim of this study was to investigate the effect of 8 weeks of interval training on inflammatory factors in overweight adolescent boys. In a quasi-experimental research project, from overweight adolescent boys (13-18 years old, mean height 154.33 cm, mean body mass index 27.05 kg/m2), 30 subjects were voluntarily assigned to 3 groups (10 subjects each group): short-term interval training (nine 30-second bouts, 100 to 110% of maximum speed with 150 seconds of rest), long-term (four 150-second bouts, 90 to 95% of maximum speed with 240 seconds of rest) and control. 48 hours before the beginning and the end of the training protocol, weight, height, body mass index and fat percentage were measured by a body composition apparatus and blood samples were collected to determine the interleukin-6, interleukin-10 and C-reactive protein indices. The results showed that 8 weeks of high intensity interval training increased interleukin-10 and decreased C-reactive protein. But it had no significant effect on interleukin-6. It was also found that there were no differences between short-term and long-term HIIT in influencing the desired indicators. Based on these findings, it can be said that overweight or obese adolescents may be able to use HIIT to boost their anti-inflammatory system by increasing interleukin-6 and decreasing C-reactive protein. But more studies are needed to determine the effect of this training on interleukin-6.
کلیدواژه‌ها [English]
- C-reactive protein
- high intensity interval training
- interleukin-6
- interleukin-10
- overweigh
- World Health Organization. Global Health Observatory (GHO) data: Obesity. World Health Organization. Available from www. who. int/gho/ncd/risk_factors/overweight/en/ Accessed. 2016 Aug;17.
- Mirzazadeh A, Sadeghirad B, HAGHDOUST A, Bahreyni F, Rezazadeh KM. The prevalence of obesity in Iran in recent decade; a systematic review and meta-analysis study.
- Ghasemnian A, Ghaeini A, Kordi M, Hedayati M, Rami M, Ghorbanian B. Effect of interval endurance training program on plasma eotaxin, adiponectin levels, insulin resistance, serum lipid profile and body composition in overweight and obese adolescents. Studies in Medical Sciences. 2013 Sep 10;24(6):430-40.
- Valle M, Martos R, Gascon F, Canete R, Zafra MA, Morales R. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes & metabolism. 2005 Feb 1;31(1):55-62.
- Chen SB, Lee YC, Ser KH, Chen JC, Chen SC, Hsieh HF, Lee WJ. Serum C-reactive protein and white blood cell count in morbidly obese surgical patients. Obesity Surgery. 2009 Apr 1;19(4):461-6.
- Ambrósio G, Kaufmann FN, Manosso L, Platt N, Ghisleni G, Rodrigues AL, Rieger DK, Kaster MP. Depression and peripheral inflammatory profile of patients with obesity. Psychoneuroendocrinology. 2018 May 1;91:132-41.
- Pearson MJ, Mungovan SF, Smart NA. Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis. Heart Failure Reviews. 2018 Mar 1;23(2):209-23.
- Buch A, Kis O, Carmeli E, Keinan-Boker L, Berner Y, Barer Y, Shefer G, Marcus Y, Stern N. Circuit resistance training is an effective means to enhance muscle strength in older and middle aged adults: a systematic review and meta-analysis. Ageing research reviews. 2017 Aug 1;37:16-27.
- Cassidy S, Thoma C, Houghton D, Trenell MI. High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia. 2017 Jan 1;60(1):7-23.
- Vella CA, Taylor K, Drummer D. High-intensity interval and moderate-intensity continuous training elicit similar enjoyment and adherence levels in overweight and obese adults. European journal of sport science. 2017;17(9):1203-11.
- Bahmanbeglou NA, Ebrahim K, Maleki M, Nikpajouh A, Ahmadizad S. Short-Duration High-Intensity Interval Exercise Training Is More Effective Than Long Duration for Blood Pressure and Arterial Stiffness But Not for Inflammatory Markers and Lipid Profiles in Patients With Stage 1 Hypertension. Journal of Cardiopulmonary Rehabilitation and Prevention. 2019 Jan 1;39(1):50-5.
- Ahmadizad S, Avansar AS, Ebrahim K, Avandi M, Ghasemikaram M. The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Hormone molecular biology and clinical investigation. 2015 Mar 1;21(3):165-73.
- Kaspar F, Jelinek HF, Perkins S, Al-Aubaidy HA, Dejong B, Butkowski E. Acute-phase inflammatory response to single-bout HIIT and endurance training: a comparative study. Mediators of inflammation. 2016 Jan 1;2016.
- Munk PS, Breland UM, Aukrust P, Ueland T, Kvaløy JT, Larsen AI. High intensity interval training reduces systemic inflammation in post-PCI patients. European Journal of Cardiovascular Prevention & Rehabilitation. 2011 Dec;18(6):850-7.
- Loomba-Albrecht, L. A., & Styne, D. M. (2009). Effect of puberty on body composition. Current Opinion in Endocrinology, Diabetes and Obesity, 16(1), 10-15.
- Thivel D, Masurier J, Baquet G, Timmons BW, Pereira B, Berthoin S, Duclos M, Aucouturier J. High-intensity interval training in overweight and obese children and adolescents: systematic review and meta-analysis. The Journal of sports medicine and physical fitness. 2019 Feb;59(2):310-24.
- A.B. Gray, R.D. Telford, M. Collins, et al. The response of leukocyte subsets and plasma hormones to interval exercise Med. Sci. Sports Exerc., 25 (1993), pp. 1252-1258
- H. Schipper, B. Prakken, E. Kalkhoven, et al. Adipose tissue-resident immune cells: key players in immunometabolism Trends Endocrinol. Metab., 23 (8) (2012), pp. 407-415
- Mela V, Hernandez O, Hunsche C, Diaz F, Chowen JA, De la Fuente M (2017) Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal/adolescent rats. Mol Cell Endocrinol 454:125–134. https://doi.org/10.1016/j.mce.2017.06.018
- Cabral-Santos C, Gerosa-Neto J, Inoue DS, Panissa VL, Gobbo LA, Zagatto AM, Campos EZ, Lira FS. Similar Anti-Inflammatory Acute responses from moderate-intensity continuous and high-intensity intermittent exercise. J Sports Sci Med 2015;14:849-856
- Pedersen BK. Muscular interleukin-6 and its role as an energy sensor. Med Sci Sports Exerc 2012;44:392-396
- Tschakert G, Kroepfl J, Mueller A, Moser O, Groeschl W, Hofmann P. How to regulate the acute physiological response to “aerobic” high-intensity interval exercise. J Sports Sci Med 2015;14:29-36
- Garanty-Bogacka B, Rać M, Syrenicz M, Gębala A, Walczak M, Syrenicz A. Changes in serum adipocytokines and inflammatory biomarkers following one-year of exercise training in obese adolescents. J Diabetes Metab. 2012;3(7):212-7.
- Imayama I, Ulrich CM, Alfano CM, Wang C, Xiao L, Wener MH, Campbell KL, Duggan C, Foster-Schubert KE, Kong A, Mason CE. Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. Cancer research. 2012 May 1;72(9):2314-26.
- Pou Karla M, Massaro Joseph M, Hoffmann Udo VR, Maurovich-Horvat Pal LM, Keaney John F, Meigs James B, Lipinska Izabella KS, Murabito Joanne M, O’Donnell Christopher J, Benjamin Emelia J, Fox Caroline S. Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress. Circulation. 2007;116(11):1234-41.
- Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. Jama. 1999 Dec 8;282(22):2131-5.
- Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008;56(11):2045-52
- Oishi, Y., Taniguchi, K., Matsumoto, H., Ishihara, A., Ohira, Y., & Roy, R. R. (2002). Muscle type-specific response of HSP60, HSP72, and HSC73 during recovery after elevation of muscle temperature. Journal of Applied Physiology, 92(3), 1097-1103.
- Naser al-Islami, Mousavi Nairi, Neda, Aboutaleb, & Goodarzi. (2018). Comparison of the effect of active and inactive recovery methods after a HIIT activity on the response of CRP, IL6 and cortisol. Biological Knowledge of Iran, 13 (2), 11-17[IN PERSIAN].
- Cullen, T., Thomas, A. W., Webb, R., & Hughes, M. G. (2016). Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume. Applied physiology, nutrition, and metabolism, 41(8), 803-808.
- Ye, J., & Keller, J. N. (2010). Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction. Aging (Albany NY), 2(6), 361.
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