نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 استادیار گروه تربیت بدنی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران

2 استاد گروه فیزیولوژی ورزش، دانشکدة تربیت بدنی، دانشگاه تهران، تهران، ایران

3 دانشیار گروه فیزیولوژی ورزش، دانشکدة تربیت بدنی، دانشگاه تهران، تهران، ایران

4 مدیر گروه پاتوبیولوژی دانشکدۀ بهداشت و انستیتو تحقیقات بهداشتیِ دانشگاه علوم پزشکی تهران

5 دانشجوی دکتری ایمونولوژی بالینی دانشگاه علوم پزشکی تهران.تهران.ایران

چکیده

آدیپولین (CTRP12) آدیپوکاینی است نوظهور با خاصیت ضدالتهابی که عمدتاً در بافت چربی بیان و سنتز می­شود. آدیپولین ضمن بهبود حساسیت به انسولین، در کاهش سطح گلوکز خون نیز نقش دارد. پژوهش حاضر تاثیر تمرینات مقاومتی بر سطوح آدیپولین و شاخص مقاومت به انسولین (HOMA-IR) را در زنان چاق مورد بررسی قرار داده است. بدین منظور 20 زن چاقِ یائسه و غیرفعال (شاخص تودۀ بدنی> 30 کیلوگرم بر مترمربع، 65-50 سال) به طور تصادفی به دو گروه تجربی (12 نفر) و کنترل (8 نفر) تقسیم شدند. گروه تجربی در 12 هفته تمرینات مقاومتی (سه دوره با 12-8 تکرار در شدت 60-40 درصد یک تکرار بیشینه)، 45-15 دقیقه در هر جلسه، سه جلسه در هفته شرکت کردند. سطوح آدیپولین، انسولین و گلوکز ناشتا و شاخص­های آنتروپومتری قبل و 48 ساعت بعد از آخرین جلسۀ تمرین اندازه­گیری شدند. تجزیه و تحلیل داده ها با آزمون کلموگروف-اسمیرنوف، تی زوجی، تی مستقل و آزمون همبستگی پیرسون در سطح معنی داری 05/0>P انجام گرفت. نتایج نشان دادند اجرای تمرینات مقاومتی موجب تغییر معنی­دار آدیپولین سرم (05/0<P) در گروه تجربی نشد ولی با کاهش معنی­دار سطوح انسولین (032/0=P) و ارزش­های مقاومت به انسولین (031/0=P) و درصد چربی بدن (002/0=P) همراه بود. هم­چنین، تنها تغییرات بین گروهی مقاومت به انسولین (021/0=P) و نسبت محیط کمر به لگن (002/0=P) معنی­دار بود. بنابر نتایج آزمون همبستگی پیرسون ارتباط معنی­داری بین سطوح اولیه و تغییرات آدیپولین با سطوح اولیه و تغییرات شاخص­های خونی و شاخص­های آنتروپومتری پس از اجرای تمرینات مقاومتی وجود نداشت. بنابراین، تمرینات مقاومتی به عنوان یکی از راهکارهای درمانی در بهبود حساسیت به انسولین در زنان چاقِ یائسه و غیرفعال پیشنهاد می­شود، اما انجام تحقیقات بیشتر جهت تعیین مکانیسم مولکولی با میانجی­گری آدیپولین ضروری به نظر می­رسد.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Resistance Training on Serum Levels of Adipolin and Insulin Resistance in Obese Women

نویسندگان [English]

  • Najme Rezaeian 1
  • Ali asghar Ravasi 2
  • Rahman Soori 3
  • Ali Akbarnezhad 3
  • Seyyed Abbas Mirshafiey 4
  • Farzane Towfighi 5

1 Assistant Professor, Department of Physical Education, Bojnourd branch, Islamic azad university of Bojnourd, Iran

2 Professor, Department of Exercise Physiology, Faculty of Physical Education,

3 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education, University of Tehran, Tehran, Iran

4 Professor, Department of pathobiology, School of public health and institute of health research, Tehran University of Medical Sciences, Tehran, Iran

5 PhD Student in clinical immunology, Tehran University of Medical Sciences, Tehran, Iran

چکیده [English]

Adipolin(CTRP12), is a novel anti-inflammatory adipokine improves Insulin sensitivity and decreases circulating glucose levels. This study investigated effect of strengthening training on adipolin levels and insulin resistance index (HOMA-IR) in obese women.20 sedentary postmenopausal obese women(BMI>30Kg/m2,aged 50-65 years) randomly assigned in to experimental(n=12)and control(n=8)groups.Subjects in experimental group participated in 12 weeks of strengthening training(3 sets of 8-12 repetitions at 40-60% of one maximal repetition),15-45 minutes per session and three sessions per week. Levels of adipolin, insulin and fasting glucose and anthropometric indices measured before and 48 hours after last training session. Statistical analysis was done by paired and independent t-test and Pearson correlation and P0.05). Therefore, strengthening training is one of treatment procedure to improve insulin sensitivity in sedentary postmenopausal obese women. However, more studied is necessary to identify molecular mechanism mediated by adipolin.

کلیدواژه‌ها [English]

  • resisatnce Training
  • Adipolin
  • Insulin Resistance
  • Obese Women
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