نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 دانشیار، گروه علوم ورزشی، دانشکدة علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران

2 کارشناس ارشد، گروه علوم ورزشی، دانشکدة علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران

چکیده

سایتوکاین‌ها نقش مهمی در بروز بیماری MS دارند و هدف مهمی برای مداخلات درمانی به‌شمار می‌روند. هدف این مطالعه بررسی اثر تمرینات پیلاتس همراه با ماساژدرمانی بر سطوح سرمی سایتوکاین‌های IL-17 و IFN-β در زنان مبتلا به MS است. در این مطالعه از نوع کارآزمایی بالینی از میان بیماران زن دارای پرونده در انجمن MS شهرستان تبریز، تعداد 36 نفر به‌عنوان نمونه با درجة بیماری 0 تا 5/4، میانگین مدت بیماری 2±7 سال و دامنة سنی 30 تا 40 سال انتخاب و به‌صورت تصادفی به چهار گروه تمرینات پیلاتس (9نفر)، ماساژ (9نفر)، پیلاتس + ماساژ (9نفر) و کنترل (9نفر) تقسیم شدند. برنامة تمرینات پیلاتس و ماساژ شامل 8 هفته، هر هفته سه جلسه، هر جلسه 40 تا 60 دقیقه (20 تا 40 دقیقه پیلاتس و 20 تا 30 دقیقه ماساژ) بود. نمونه‌های خونی قبل و بعد از مداخله گرفته شد. تحلیل داده‌ها به‌وسیلة آزمون آماری تحلیل واریانس با استفاده از نرم‌افزار SPSS20 انجام گرفت. نتایج نشان داد در پی 8 هفته مداخلة تمرین پیلاتس و ماساژدرمانی مقدار IL-17 در گروه‌های پیلاتس، ماساژ و پیلاتس + ماساژ کاهش معنادار و مقدار IFN-β در گروه‌های ماساژ و پیلاتس + ماساژ افزایش معنادار داشتند (05/0>P). از آنجا که تمرینات پیلاتس همراه با ماساژ سبب کاهش سطوح سایتوکاین پیش‌التهابی IL-17 و افزایش IFN-β در بیماران MS شد. ازاین‌رو به‌نظر می‌رسد می‌توان از این نوع مداخله درمان مکمل در جلوگیری از پیشرفت بیماری MS در کنار درمان‌های دارویی استفاده کرد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Pilates Training and Massage Therapy on Plasma Serum Levels of IL-17 and IFN-β as pro-Inflammatory Cytokines in Patients with Multiple Sclerosis (MS)

نویسندگان [English]

  • Bahloul Ghorbanian 1
  • Akram Mahmoudpoor 2

1 Associat Professor, Department of Exercise Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran

2 MSc, Department of Exercise Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran

چکیده [English]

Cytokines play an important role in the pathogenesis of Multiple Sclerosis (MS) and are considered an important objective for therapeutic intervention. The purpose of this study was to investigate the effect of eight weeks Pilates training and massage therapy on plasma serum levels of IL_17 and IFNβ as pro-inflammatory cytokines in patients with MS. In this clinical trial study, 36 women patients (who had medical file in MS society of Tabriz, Iran) with range age from 30 to 40 years old, a degree of the disease from 0 to 4/5 and average length of disease was 7±2 yr, were selected and split in to 4 groups: massage (n=9), pilates (n=9), pilates + massage (n=9), and a control (n=9). Pilates training and massage therapy included 8 weeks, 3 sessions per week, 40-60 minutes each session (20 to 40 minutes for Pilates and 20 to 30 minutes for massage). Blood samples were taken before and after intervention. Data were analyzed by ANOVA using spss20. The results showed that after eight weeks of Pilates training and massage therapy, IL-17 levels decreased significantly in Pilates, Massage and Pilates + Massage groups, and the level of IFN-β in massage and Pilates + Massage groups increased significantly (P< 0/05). Conclusion: Since Pilates coupled with Massage reduced pro-inflammatory IL-17 cytokine and increase IFN-β in MS patients, it seems that Pilates training and massage therapy can be used as a complementary treatment along with other drug therapies for preventing the progress of MS.

کلیدواژه‌ها [English]

  • Multiple Sclerosis (MS)
  • Pilates
  • Massage
  • IL_17
  • IFN-β
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