عنوان مقاله [English]
There are little data on irisin concentration and regulation under various physiological conditions. 18 rats had a high-fat diet and 6 rats were nourished with a standard diet (non-obese) for 12 weeks. Then, non-obese group and 6 obese rats (baseline obese) were killed. 12 remaining rats were divided into training obese and control obese groups. Training group ran on a treadmill for 14 weeks, 5 days/week with high intensity. Samples were collected 48 hours after last training session. Serum irisin and leptin concentrations in baseline obese group were higher than non-obese group (P≤0.05). Training increased serum irisin and decreased serum leptin (P≤0.05). In the baseline obese group, UCP1 mRNA expression was lower than non-obese group (P≤0.05) while it was more in training group than control group (P≤0.05). There was a positive relationship between irisin and leptin in baseline obese group and a negative relationship in the training group (P≤0.05). There was a negative relationship between leptin and UCP1 in baseline obese group (P≤0.05). Although the obesity was associated with an increase in leptin and irisin, there was a negative significant relationship between leptin and UCP1. However, training led to weight loss of obese rats by leptin decrease and irisin and UCP1 increase.
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