تمرین مقاومتی با شدت‌ بالا و متوسط بر فاکتورهای مرتبط با ترمیم غلاف میلین و شاخص‌های عملکردی در زنان مبتلا به MS اثرگذار است عنوان کوتاه: تمرین مقاومتی و ترمیم غلاف میلین

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه تربیت بدنی، دانشگاه کردستان، سنندج، ایران

2 دانشیار، گروه تربیت بدنی، دانشگاه کردستان، سنندج، ایران

3 استادیار، گروه تربیت ‌بدنی، دانشگاه کردستان، سنندج، ایران

چکیده

ورزش تأثیرات مفیدی بر سلامت مغز دارد. هدف پژوهش حاضر بررسی تأثیر تمرینات مقاومتی با شدت­های مختلف بر سطوح سرمی BDNF، Claudin11 و فاکتورهای عملکردی در بیماران MS بود. 30 زن مبتلا به MS (میانگین سنی ۸/۱±۱/۳۶ سال) به­ روش هدفمند انتخاب شدند و به‌صورت تصادفی به سه گروه تجربی ۱ (انجام تمرینات مقاومتی به مدت ۱۲ هفته، هر هفته سه جلسه، با شدت %60 1RM)، گروه تجربی ۲ (انجام تمرین با شدت %85 1RM) و گروه کنترل (بدون برنامۀ تمرینی منظم) تقسیم شدند. خون‌گیری در دو نوبت (۴۸ ساعت قبل از اولین و بعد از آخرین جلسۀ تمرینی) انجام گرفت. نتایج اندازه‌گیری‌ها به روش الایزا و به کمک تحلیل واریانس با اندازه­گیری مکرر نشان داد که پس از دوازده هفته، سطوح سرمی BDNF در هر دو گروه تجربی نسبت به پیش‌آزمون افزایش معناداری یافت (001/0P=). این افزایش در گروه تجربی ۱ نسبت به گروه کنترل نیز معنادار بود (002/0P=). همچنین سطوح سرمی Claudin11، استقامت عضلانی و تعادل در گروه­های تجربی در پس‌آزمون نسبت به پیش­آزمون افزایش و خستگی کاهش معناداری یافت (001/0P=). این تغییرات در گروه­های تجربی نسبت به گروه کنترل نیز معنادار بود. علاوه‌بر بهبود تعادل، خستگی و استقامت عضلانی، یافته­های حاضر نشان داد تمرینات مقاومتی موجب افزایش سطوح Claudin11 می­شود که فاکتور مهمی در تشکیل غلاف میلین رشته­های عصبی است. همچنین افزایش سطوح BDNF که نقش اساسی در توسعه، نگهداری و ترمیم سیستم عصبی دارد، مشاهده شد. علاوه‌بر این تمرینات مقاومتی با شدت متوسط در بیشتر موارد تأثیراتی مشابه با تمرینات با شدت بالا داشت.
 

کلیدواژه‌ها


عنوان مقاله [English]

High and Moderate Resistance Training Affect Those Factors Associated with Myelin Sheath Repair and Functional Factors in Women with MS

نویسندگان [English]

  • mina ahmadi kakavandi 1
  • Dariush Sheikholeslami Vatani 2
  • saeed ghaeeni 3
1 MSc, Department of Physical Education, University of Kurdistan, Sanandaj, Iran
2 Associate Professor, Department of Physical Education, University of Kurdistan, Sanandaj, Iran
3 Assistant Professor, Department of Physical Education, University of Kurdistan, Sanandaj, Iran
چکیده [English]

Training has beneficial effects on the health of brain. The aim of this study was to evaluate the effect of resistance training with different intensities on serum levels of BDNF, Claudin11, and functional factors in MS patients. 30 women with MS (mean age 36.1 ± 1.8 years) were selected purposively, and were randomly divided into 3 groups: experimental 1 (resistance training with an intensity of 60% 1RM for 12 weeks, 3 sessions per week), experimental 2 (training with an intensity of 85% 1RM) and control (without regular training). Blood samples were collected in two steps (48 hours before the first training session and after the last training session). Results of the ELISA method and ANOVA with repeated measures showed that after 12 weeks, serum levels of BDNF in both experimental groups increased significantly compared with the pretest (P=0.001). This increase was also significant in experimental 1 group compared with the control group (P=0.002). Also, serum levels of Claudin11, muscle endurance and balance increased significantly in experimental groups in posttest compared with the pretest while fatigue decreased significantly (P=0.001). These changes were significant in experimental groups compared with the control group. These findings showed that resistance training improves balance, fatigue and muscle endurance and increases levels of Claudin11 which is an important factor in the development of myelin sheath of nerve fibers. Also, an increase in BDNF levels which play a vital role in developing, maintaining and restoring nervous system was observed. In addition, in most cases, moderate intensity resistance training had an effect similar to high intensity training.

کلیدواژه‌ها [English]

  • brain-derived neurotrophic factor
  • Multiple Sclerosis
  • resistance training
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