نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

1 کارشناسی ارشد، گروه تربیت بدنی، دانشگاه کردستان، سنندج، ایران

2 دانشیار، گروه تربیت بدنی، دانشگاه کردستان، سنندج، ایران

3 استادیار، گروه تربیت ‌بدنی، دانشگاه کردستان، سنندج، ایران

چکیده

ورزش تأثیرات مفیدی بر سلامت مغز دارد. هدف پژوهش حاضر بررسی تأثیر تمرینات مقاومتی با شدت­های مختلف بر سطوح سرمی BDNF، Claudin11 و فاکتورهای عملکردی در بیماران MS بود. 30 زن مبتلا به MS (میانگین سنی ۸/۱±۱/۳۶ سال) به­ روش هدفمند انتخاب شدند و به‌صورت تصادفی به سه گروه تجربی ۱ (انجام تمرینات مقاومتی به مدت ۱۲ هفته، هر هفته سه جلسه، با شدت %60 1RM)، گروه تجربی ۲ (انجام تمرین با شدت %85 1RM) و گروه کنترل (بدون برنامۀ تمرینی منظم) تقسیم شدند. خون‌گیری در دو نوبت (۴۸ ساعت قبل از اولین و بعد از آخرین جلسۀ تمرینی) انجام گرفت. نتایج اندازه‌گیری‌ها به روش الایزا و به کمک تحلیل واریانس با اندازه­گیری مکرر نشان داد که پس از دوازده هفته، سطوح سرمی BDNF در هر دو گروه تجربی نسبت به پیش‌آزمون افزایش معناداری یافت (001/0P=). این افزایش در گروه تجربی ۱ نسبت به گروه کنترل نیز معنادار بود (002/0P=). همچنین سطوح سرمی Claudin11، استقامت عضلانی و تعادل در گروه­های تجربی در پس‌آزمون نسبت به پیش­آزمون افزایش و خستگی کاهش معناداری یافت (001/0P=). این تغییرات در گروه­های تجربی نسبت به گروه کنترل نیز معنادار بود. علاوه‌بر بهبود تعادل، خستگی و استقامت عضلانی، یافته­های حاضر نشان داد تمرینات مقاومتی موجب افزایش سطوح Claudin11 می­شود که فاکتور مهمی در تشکیل غلاف میلین رشته­های عصبی است. همچنین افزایش سطوح BDNF که نقش اساسی در توسعه، نگهداری و ترمیم سیستم عصبی دارد، مشاهده شد. علاوه‌بر این تمرینات مقاومتی با شدت متوسط در بیشتر موارد تأثیراتی مشابه با تمرینات با شدت بالا داشت.
 

کلیدواژه‌ها

عنوان مقاله [English]

High and Moderate Resistance Training Affect Those Factors Associated with Myelin Sheath Repair and Functional Factors in Women with MS

نویسندگان [English]

  • Mina Ahmadi kakavandi 1
  • Dariush Sheikholeslami Vatani 2
  • Saeed Ghaeeni 3

1 MSc, Department of Physical Education, University of Kurdistan, Sanandaj, Iran

2 Associate Professor, Department of Physical Education, University of Kurdistan, Sanandaj, Iran

3 Assistant Professor, Department of Physical Education, University of Kurdistan, Sanandaj, Iran

چکیده [English]

Training has beneficial effects on the health of brain. The aim of this study was to evaluate the effect of resistance training with different intensities on serum levels of BDNF, Claudin11, and functional factors in MS patients. 30 women with MS (mean age 36.1 ± 1.8 years) were selected purposively, and were randomly divided into 3 groups: experimental 1 (resistance training with an intensity of 60% 1RM for 12 weeks, 3 sessions per week), experimental 2 (training with an intensity of 85% 1RM) and control (without regular training). Blood samples were collected in two steps (48 hours before the first training session and after the last training session). Results of the ELISA method and ANOVA with repeated measures showed that after 12 weeks, serum levels of BDNF in both experimental groups increased significantly compared with the pretest (P=0.001). This increase was also significant in experimental 1 group compared with the control group (P=0.002). Also, serum levels of Claudin11, muscle endurance and balance increased significantly in experimental groups in posttest compared with the pretest while fatigue decreased significantly (P=0.001). These changes were significant in experimental groups compared with the control group. These findings showed that resistance training improves balance, fatigue and muscle endurance and increases levels of Claudin11 which is an important factor in the development of myelin sheath of nerve fibers. Also, an increase in BDNF levels which play a vital role in developing, maintaining and restoring nervous system was observed. In addition, in most cases, moderate intensity resistance training had an effect similar to high intensity training.

کلیدواژه‌ها [English]

  • brain-derived neurotrophic factor
  • Multiple Sclerosis
  • resistance training
1.   DeBolt LS, McCubbin JA. The effects of home-based resistance exercise on balance, power, and mobility in adults with multiple sclerosis1. Archives of physical medicine and rehabilitation. 2004;85(2):290-7.
2.   Trapp BD, Peterson J, Ransohoff RM, RudickR, Mörk S, Bö L. Axonal transection in the lesions of multiple sclerosis. New England Journal of Medicine. 1998;338(5):278-85.
3.   Frota ERC, Rodrigues DH, Donadi EA, Brum DG, Maciel DRK, Teixeira AL. Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse. Neuroscience letters. 2009;460(2):130-2.
4.   Vega SR, Strüder HK, Wahrmann BV, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exerciseto exhaustion in humans. Brain research. 2006;1121(1):59-65.
5.   Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, et al. Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise. Experimental physiology. 2009;94(10):1062-9.
6.   Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112(2):257-69.
7.   LinkerRA, Lee D-H, Demir S, Wiese S, Kruse N, Siglienti I, et al. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain. 2010;133(8):2248-63.
8.   Van't Veer A, Du Y, Fischer TZ, Boetig DR, Wood MR, Dreyfus CF. Brain‐derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway. Journal of neuroscience research. 2009;87(1):69-78.
9.   Wujek JR, Bjartmar C, Richer E, Ransohoff RM, Yu M, Tuohy VK, et al. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. Journal of Neuropathology & Experimental Neurology. 2002;61(1):23-32.
10.Sorenson M, Jason L, Peterson J, Herrington J, Mathews H. Brain derived neurotrophic factor is decreased in chronic fatigue syndrome and multiple sclerosis. J Neurol Neurophysiol S. 2014;12:S2-013.
11.Bronstein J, Micevych P, Chen K. Oligodendrocyte‐specific protein (OSP) is a major component of CNS myelin. Journal of neuroscience research. 1997;50(5):713-20.
12.Morita K, Sasaki H, Fujimoto K, Furuse M, Tsukita S. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. The Journal of cell biology. 1999;145(3):579-88.
13.Bronstein JM, Kozak CA, Chen X-N, Wu S, Danciger M, Korenberg JR, et al. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996;34(2):255-7.
14.BuznikovA, Vu T, Kornblum H, Chen K, Bronstein J, editors. Cloning of the human oligodendrocyte-specific protein (OSP) homologue. Soc Neurosci; 1996.
15.Bronstein J, Lallone R, Seitz R, Ellison G, Myers L. A humoral response to oligodendrocyte-specific protein in MS A potential molecular mimic. Neurology. 1999;53(1):154.
16.Devaux J, Gow A. Tight junctions potentiate the insulative properties of small CNS myelinated axons. The Journal of cell biology. 2008;183(5):909-21.
17.Gow A, Southwood CM, Li JS, ParialiM, Riordan GP, Brodie SE, et al. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell. 1999;99(6):649-59.
18.Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK. GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacology & therapeutics. 2013;138(2):155-75.
19.Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993;361(6407):31.
20.Betterle C, Lazzarotto F, Presotto F. Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? Clinical & Experimental Immunology. 2004;137(2):225-33.
21.Wens I, Keytsman C, Deckx N, Cools N, Dalgas U, Eijnde BO. Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training. European journal of neurology. 2016;23(6):1028-35.
22.Castellano V, White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. Journal of the neurological sciences. 2008;269(1):85-91.
23.Ozkul C, Guclu-Gunduz A, Irkec C, Fidan I, Aydin Y, Ozkan T, et al. Effect of combined exercise training on serum brain-derived neurotrophic factor, suppressors of cytokine signaling 1 and 3 in patients with multiple sclerosis. Journal of neuroimmunology. 2018;121:316-9.
24.Gold SM, Schulz K-H, Hartmann S, Mladek M, Lang UE, Hellweg R, et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. Journal of neuroimmunology. 2003;138(1-2):99-105.
25.White L, McCoy S, Castellano V, Gutierrez G, Stevens J, Walter G, et al. Resistance training improves strength and functional capacity in persons with multiple sclerosis. Multiple Sclerosis Journal. 2004;10(6):668-74.
26.Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen H, Knudsen C, et al. Fatigue, mood and quality of life improve in MS patients after progressive resistance training. Multiple Sclerosis Journal. 2010;16(4):480-90.
27.TOFIGHI AA, SAKI Y, RAZMJOO K. Effect of 12-week progressive resistance training on balance, fatigue and disability in women with MS. 2013.
28.Hayes HA, Gappmaier E, LaStayo PC. Effects of high-intensity resistance training on strength, mobility, balance, and fatigue in individuals with multiple sclerosis: a randomized controlled trial. Journal of Neurologic Physical Therapy. 2011;35(1):2-10.
29.Taylor N, Dodd K, Prasad D, Denisenko S. Progressive resistance exercise for people with multiple sclerosis. Disability andrehabilitation. 2006;28(18):1119-26.
30.Brzycki M. A practical approach to strength training: Contemporary Books; 1995.
31.Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. Journal of the American geriatrics Society. 1991;39(2):142-8.
32.Heyward V. Assessing cardiorespiratory fitness. Advanced fitness assessment and exercise prescription. 1998;5:55-92.
33.Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of neurology. 1989;46(10):1121-3.
34.Ferris LT, Williams JS, Shen C-L. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Medicine & Science in Sports & Exercise. 2007;39(4):728-34.
35.Schulz K-H, Gold SM, Witte J, Bartsch K, Lang UE, Hellweg R, et al. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative functionin multiple sclerosis. Journal of the neurological sciences. 2004;225(1-2):11-8.
36.Pitts EV, Potluri S, Hess DM, Balice-Gordon RJ. Neurotrophin and Trk-mediated signaling in the neuromuscular system. International anesthesiology clinics. 2006;44(2):21-76.
37.Banan A, Zhang L, Shaikh M, Fields J, Choudhary S, Forsyth C, et al. θ Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. Journal of Pharmacology and Experimental Therapeutics. 2005;313(3):962-82.
38.D'Souza T, Agarwal R, Morin PJ. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. Journal of Biological Chemistry. 2005;280(28):26233-40.
39.de Souza-Teixeira F, Costilla S, Ayan C, Garcia-Lopez D, Gonzalez-Gallego J, De Paz J. Effects of resistance training in multiple sclerosis. International journal of sports medicine. 2009;30(04):245-50.
40.Carroll TJ, Benjamin B, Stephan R, Carson RG. Resistance training enhances the stability of sensorimotor coordination. Proceedings of the Royal Society of London B: Biological Sciences. 2001;268(1464):221-7.
41.Anderson K, Behm DG. The impact of instability resistance training on balance and stability. Sports medicine. 2005;35(1):43-53.
42.O’Sullivan PB, Mitchell T, Bulich P, Waller R, Holte J. The relationship beween posture and back muscle endurance in industrial workers with flexion-related low back pain. Manual therapy. 2006;11(4):264-71.
43.Philip SK. Trunk control correlates with gait and balance measures in elderly subjects including high functioning individuals with Parkinson disease: The Ohio State University; 2009.
44.AndreasenAK, Jakobsen J, Petersen T, Andersen H. Fatigued patients with multiple sclerosis have impaired central muscle activation. Multiple Sclerosis Journal. 2009;15(7):818-27.
45.Sale DG. Neural adaptation to resistance training. Medicine and science in sports and exercise. 1988;20(5 Suppl):S135-45.
46.Merlio J-P, Ernfors P, Jaber M, Persson H. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience. 1992;51(3):513-32.
47.Madhav T, Pei Q, Zetterström T. Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF). Molecular brain research. 2001;93(1):56-63.