اثر هشت هفته تمرین تناوبی بر سطوح آدیپوکین ها ( آدیپونکتین و PAI-1 ) و ملکول چسبان (VCAM-1) سرمی زنان غیرفعال چاق

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانش‌آموختۀ کارشناسی‌ارشد، گروه تربیت‌بدنی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران

2 دانشیار گروه تربیت‌بدنی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران

چکیده

هدف از تحقیق حاضر اثر هشت هفته تمرین بر آدیپونکتین، PAI-1، VCAM-1 در زنان غیرفعال میان‌سال هست. به همین منظور 40 زن (BMI بین 25-30 کیلوگرم بر مترمربع) با دامنه سنی 45 تا 35 سال به‌طور داوطلبانه به دو گروه تمرین و کنترل (20==n) قرار گرفتند. گروه تمرین به مدت 8 هفته (سه جلسه در هفته سه اینتروال سرعتی 10 ثانیه با تناوب‌های استراحتی 30 ثانیه بین اینتروال ها و به دنبال آن سه تناوب سرعتی 30 ثانیه‌ای با تناوب‌های استراحتی 90 ثانیه) به فعالیت پرداختند.دو روز قبل و بعد از آخرین جلسه تمرین در حالت‌ ناشتا ترکیب بدنی و فاکتورهای خونی اندازه‌گیری شد. نتایج آزمون تی مستقل نشان داد که پس از هشت هفته تمرین سطح آدیپونکتین سرم گروه تجربی به‌طور معنی داری افزایش یافت (p<0.05) و سطح VCAM-1 و PAI-1 سرمی کاهش معناداری یافت، همچنین درصد چربی بدن، شاخص توده بدنی و محیط دور کمر بعد یک دوره تمرین در گروه تجربی کاهش و حداکثر اکسیژن مصرفی افزایش یافت (p<0.05)؛ بنابراین می‌توان گفت که تمرین تناوبی باعث افزایش آدیپونکتین، همچنین کاهش VCAM-1 و PAI-1 می‌شود که این تغییرات می‌تواند باعث بهبود کیفیت زندگی در زنان غیرفعال چاق گردد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Eight Week Interval training on The Serum VCAM-1 and PAI-1 in Obesity Women

نویسندگان [English]

  • Niloufar Mosaffa 1
  • bahram abedi 2
1 MSc, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
2 Associate Professor, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
چکیده [English]

The aim of this study was to investigate the effect of eight weeks of interval training on adiponectin, PAI-1, and VCAM-1 in sedentary middle-aged women. For this purpose, 40 sedentary middle-aged overweight women (BMI 25-30 kg/m2, age range 35-45 years) volunteered to participate in the study. They were divided into two groups: interval training (n=20) and control (n=20). Interval training group worked for 8 weeks (3 sessions per week, three 10-second speed intervals with 30-second rest intervals followed by three 30-second speed intervals with 90-second rest intervals). In order to increase overload, the number of intervals increased (an interval per week) after two weeks. Two days before and after the last training session, body composition and blood factors were measured in fasting state. Independent t test results showed that after 8 weeks of interval training, serum adiponectin level significantly increased compared to the control group (P<0.05) and serum VCAM-1 and PAI-1 levels decreased significantly. Also, body fat percentage, body mass index and waist circumference followed a period of interval training decreased and the maximum oxygen consumption increased (P<0.05). Therefore, it can be said that interval training increases adiponectin (a regulator of body metabolism); it also decreases VCAM-1 and PAI-1 which can improve the quality of life in sedentary obese women.

کلیدواژه‌ها [English]

  • Adhesion molecules
  • Adipokine
  • interval training
  • obese women

1.   Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Archives of medical science: AMS. 2017;13(4):851.

2.   Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. International journal of molecular sciences. 2017;18(6):1321.

3.   Pieters M, Barnard SA, Rijken DC. The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. PloS one. 2017;12(2):e0171271.

4.   Lee S, Hong H, Han T, Kang H. Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biology of sport. 2015;32(3):181.

5.   García-Hermoso A, Ceballos-Ceballos R, Poblete-Aro C, Hackney A, Mota J, Ramirez-Velez R. Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials. International Journal of Obesity. 2017;41(4):475.

6.   Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. The Lancet. 2010;375(9733):2267-77.

7.   Agrotou S, Karatzi K, Papamichael C, Fatouros I, Mitrakou A, Zakopoulos N, et al. Effects of chronic anaerobic training on markers of sub-clinical atherosclerosis. Hellenic J Cardiol. 2013;54(3):178-85.

8.   Jalaly L, Sharifi G, Faramarzi M, Nematollahi A, Rafieian-Kopaei M, Amiri M, et al. Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise and their combination on the serum levels of ICAM-1 and E-Selectin in patients with stable angina pectoris. DARU Journal of Pharmaceutical Sciences. 2015;23(1):54.

9.   Figueiredo L, Nunes RB, Marmett B, de Sá LBPC, Arbex AK. Anti-inflammatory effects of physical exercise on obesity. Open Journal of Endocrine and Metabolic Diseases. 2017;7(01):44.

10. Lee KW, Lip GY. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Archives of internal medicine. 2003;163(19):2368-92.

11. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism. 2005;54(11):1472-9.

12. Nikbakht H, Gaeini A, Salamat K. The effect of endurance training on serum adhesion molecules in overweight men. Scientific Journal of Kurdistan University of Medical Sciences. 2016;21(3).

13. Strömberg A, Rullman E, Jansson E, Gustafsson T. Exercise-induced upregulation of endothelial adhesion molecules in human skeletal muscle and number of circulating cells with remodeling properties. Journal of Applied Physiology. 2017;122(5):1145-54.

14. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. American Journal of Physiology-Endocrinology And Metabolism. 2002;283(4):E861-E5.

15. Avazpor S, Kalkhoran JF, Amini HA. Effect of 8 Weeks of High Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses. Novelty in Biomedicine. 2016;4(3):87-92.

16. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology. 2012;112(8):1353-60.

17. Simpson KA, Singh MAF. Effects of exercise on adiponectin: a systematic review. Obesity. 2008;16(2):241-56.

18. Coker RH, Hays NP, Williams RH, Brown AD, Freeling SA, Kortebein PM, et al. Exercise-induced changes in insulin action and glycogen metabolism in elderly adults. Medicine & Science in Sports & Exercise. 2006;38(3):433-8.

19. Zhang H, Tong TK, Qiu W, Zhang X, Zhou S, Liu Y, et al. Comparable effects of high-intensity interval training and prolonged continuous exercise training on abdominal visceral fat reduction in obese young women. Journal of diabetes research. 2017;2017.

20. Patané G, Caporarello N, Marchetti P, Parrino C, Sudano D, Marselli L, et al. Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation. Acta diabetologica. 2013;50(6):851-7.

21. Haff GG, Triplett NT. Essentials of strength training and conditioning 4th edition: Human kinetics; 2015.

22. Kimoto R, Kambayashi I, Ishimura N, Nakamura T. Effect of aged garlic extract supplementation on the change of urinary 8-OHdG content during daily regular and temporary intense exercise. Hokkaido J Med Sci. 2005;10:17-26.

23. Mahan L, Escott-Stump S. Macronutrients: Carbohydrates, Proteins, and Lipids” by: Susan Etlinger Chapter 3-pp. 50-62.“Medical Nutrition Therapy in Cardiovascular Disease” by: Debra, A. Krummel Chapter 35-pp: 860-844. Krauses Food Nutrition and Diet Therapy/11th ed SAUNDERS. 2004.

24. Terada T, Friesen A, Chahal BS, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes research and Clinical practice. 2013;99(2):120-9.

25. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. European heart journal. 2001;22(9):791-7.

26. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation. 2003;108(5):530-5.

27. Signorelli SS, Mazzarino MC, Pino LD, Malaponte G, Porto C, Pennisi G, et al. High circulating levels of cytokines (IL-6 and TNFa), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test. Vascular Medicine. 2003;8(1):15-9.

28. Zoppini G, Targher G, Zamboni C, Venturi C, Cacciatori V, Moghetti P, et al. Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases. 2006;16(8):543-9.

29. Wegge JK, Roberts CK, Ngo TH, Barnard RJ. Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease. Metabolism. 2004;53(3):377-81.

30. Sabatier MJ, Schwark EH, Lewis R, Sloan G, Cannon J, McCully K. Femoral artery remodeling after aerobic exercise training without weight loss in women. Dynamic Medicine. 2008;7(1):13.

31. Hjelstuen A, Anderssen SA, Holme I, Seljeflot I, Klemsdal TO. Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. American journal of hypertension. 2006;19(7):669-75.

32. Esmat S, Al Salam RA, Rashed L. Effect of exercise on plasminogen activator inhibitor-1 (PAI-1) level in patients with metabolic syndrome. J Am Sci. 2010;6(12):1374-80.

33. Coppola L, Grassia A, Coppola A, Tondi G, Peluso G, Mordente S, et al. Effects of a moderate-intensity aerobic program on blood viscosity, platelet aggregation and fibrinolytic balance in young and middle-aged sedentary subjects. Blood coagulation & fibrinolysis. 2004;15(1):31-7.

34. Bartzeliotou AI, Margeli AP, Tsironi M, Skenderi K, Bacoula C, Chrousos GP, et al. Circulating levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged brisk exercise. Clinical biochemistry. 2007;40(11):765-70.

35. Jialal I, Devaraj S, Kaul N. The effect of α-tocopherol on monocyte proatherogenic activity. The Journal of nutrition. 2001;131(2):389S-94S.

36. Janand-Delenne B, Chagnaud C, Raccah D, Alessi M, Juhan-Vague I, Vague P. Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women. International journal of obesity. 1998;22(4):312.

37. Alessi M, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes. 1997;46(5):860-7.

38. Buchan DS, Ollis S, Young JD, Cooper S-M, Shield JP, Baker JS. High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents. BMC public health. 2013;13(1):498.

39. Huang H, Iida KT, Sone H, Yokoo T, Yamada N, Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. Journal of endocrinology. 2006;189(3):643-53.

40. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. Journal of applied physiology. 2007;102(4):1439-47.

41. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Experimental biology and medicine. 2007;232(2):184-94.

42. Zhang Y, Zhang Y, Mills PJ, Rehman J. Dynamic Exercise Can Acutely Increase Circulating Adiponectin. Circulation. 2006;114(18 Supplement):II_881.