تأثیر هشت هفته تمرین همزمان با مکمل‌دهی ال_آرژنین بر8-isoPGF2α ، SOD ، GPX و CAT مردان سالمند

نوع مقاله: مقاله پژوهشی


1 استادیار گروه فیزیولوژی ورزش دانشگاه سمنان، سمنان،ایران

2 استادیار گروه فیزیولوژی ورزش دانشگاه سمنان، سمنان ایران

3 کارشناس‌ارشد فیزیولوژی ورزش دانشگاه سمنان، سمنان، ایران


هدف از پژوهش حاضر بررسی تأثیر هشت هفته تمرین همزمان با مکمل یاری ال_آرژنین بر SOD، CAT GPX و 8-isoPGF2α مردان سالمند بود. به همین منظور، 44 مرد سالمند با میانگین سنی 61/4 ± 77/67 سال، قد 22/3 ± 38/168 سانتی‌متر و وزن 99/4 ± 45/70 کیلوگرم به‌طور داوطلبانه و هدفمند، انتخاب و به‌صورت تصادفی به چهار گروه 11 نفری (گروه تمرین + مکمل(ES)، گروه تمرین+ دارونما (EP)، گروه مکمل و گروه کنترل) تقسیم شدند. گروه‌های تمرین، هشت هفته پروتکل تمرین را هر هفته سه جلسه، یک روز در میان انجام دادند. گروه ES و گروه مکمل، روزانه 1000 میلی‌گرم ال_آرژنین را یک ساعت پس از صبحانه، و یک ساعت پیش از تمرین، مصرف کردند. از روش الایزا برای اندازه‌گیری متغیرهای بیوشیمیایی و از آزمون تحلیل واریانس برای تحلیل داده‌ها در سطح معناداری 05/0> P استفاده شد. نتایج تحلیل واریانس چندمتغیره، تأثیر معنادار گروه بر متغیر پنهان فشار اکسایشی (SOD، CAT، GPX و 8-isoPGF2α) را نشان داد (003/0wilks lambada=، partial eta square=0/86، P<0/001). همچنین نتایج تحلیل واریانس تک‌متغیره نشان‌دهندۀ تأثیر معنادار گروه بر تک‌تک متغیرهای فشار اکسایشی بود (001/0>P). براساس یافته‌های پژوهش، سالمندان با بهره‌گیری از اثر تمرین همزمان مقاومتی و استقامتی و مصرف روزانه 1000 میلی‌گرم مکمل ال_آرژنین که احتمالاً موجب کاهش بیشتر شاخص فشار اکسایشی و بهبود سیستم آنتی‌اکسیدانی آنها می‌شود، ضمن تقویت سیستم دفاع آنتی‌اکسیدانی، می‏توانند موجبات ارتقای سلامت خود را فراهم سازند.


عنوان مقاله [English]

The Effect of 8 Weeks of Concurrent Training with L-Arginine Supplementation on 8-isoPGF2α, SOD, GPX and CAT in Elderly Men

نویسندگان [English]

  • Roholah Haghshenas 1
  • Jalil Avandi 2
  • Nazanin Jalili 3
1 Assistant Professor, Department of Exercise Physiology, Semnan University, Semnan, Iran
2 Assistant Professor, Department of Exercise Physiology, Semnan University, Semnan, Iran
3 MSc of Exercise Physiology, Semnan University, Semnan, Iran
چکیده [English]

The aim of this study was to evaluate the effect of 8 weeks of concurrent training with supplementation of L-arginine on SOD, GPX, CAT and 8-isoPGF2α in the male elderly. 44 male elderly (mean age: 67.77 ± 4.61, height: 168.38 ± 3.22 and weight: 70.45 ± 4.99) were selected voluntarily and purposively, and randomly divided into 4 groups (each group 11 subjects): training + supplements (ES), training + placebo (EP), supplement and control. Training groups completed 8 weeks of the training protocol every other day, 3 sessions per week. ES and supplementation groups daily received 1000 mg of L-arginine one hour after their breakfast and one hour before the training. ELISA method was used to measure biochemical variables and analysis of variance was used to analyze data at PP<0.001). Also, univariate analysis of variance showed the significant effect of group on every variable of oxidative stress (P<0.001). According to the findings of this study, elderly men could benefit from the effect of concurrent resistance and endurance training and consumption of 1000 mg L-arginine every day which probably reduces more oxidative stress indicator and improves their antioxidant system and could improve antioxidant defense system which improves their health.

کلیدواژه‌ها [English]

  • Antioxidant
  • concurrent training
  • oxidative stress
  • supplement


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