تأثیر چهار هفته تمرین هوازی بر اختلالات شناختی و عملکرد حرکتی موش‌های صحرایی نر دیابتی‌شده با استرپتوزوتوسین

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکدۀ ادبیات و علوم انسانی، دانشگاه ایلام، ایلام، ایران

2 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشگاه پیام نور، تهران، ایران

چکیده

 
هدف از این پژوهش، بررسی تأثیر چهار هفته تمرین هوازی بر اختلالات شناختی و عملکرد حرکتی موش‌های صحرایی نر دیابتی بود. به این منظور 24 سر موش صحرایی نر بالغ نژاد ویستار (وزن 9/9±275 گرم، سن 13 هفته) خریداری و به‌طور تصادفی به سه گروه شم، دیابت و دیابت+تمرین تقسیم شدند. دیابت با تزریق داخل‌صفاقی یک دوز استرپتوزوتوسین به مقدار ml/kg 60 القا شد. ملاک دیابتی شدن، قند خون بالای mg/dl 250 بود. یک هفته پس از القای دیابت، رت‌های گروه ورزش، به مدت چهار هفته، پنج روز در هفته (به مدت 30-20 دقیقه با سرعت 18-10 متر در دقیقه) روی تردمیل دویدند. از آزمون حافظۀ احترازی غیرفعال برای بررسی میزان اختلال در حافظه و از آزمون­های سطح شیبدار و بارفیکس به‌منظور ارزیابی عملکرد حرکتی استفاده شد. یافته­ها نشان داد که تمرین ورزشی به‌طور معنا­داری میزان اختلال ناشی از دیابت در حافظۀ کوتاه‌مدت در آزمون حافظۀ احترازی غیرفعال (0001/0=P) را کاهش و عملکرد حرکتی موش‌های صحرایی دیابتی را در آزمون سطح شیبدار (017/0=P) و آزمون بارفیکس (0001/0=P) افزایش داد. به‌طور کلی می­توان گفت که چهار هفته تمرین هوازی به بهبود اختلالات شناختی و عملکرد حرکتی در موش­های صحرایی دیابتی‌شده با استرپتوزوتوسین منجر می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 4 Weeks of Aerobic Exercise on Cognitive Impairment and Motor Dysfunction in Streptozotocin-Induced Diabetic Male Rats

نویسندگان [English]

  • Nabi Shamsaei 1
  • Hadi Abdi 2
  • Shamseddin Rezaei 1
  • Mojgan Salehipour 1
1 Assistant Professor, Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Ilam University, Ilam, Iran
2 Assistant Professor, Department of Physical Education and Sport Sciences, Payame Noor University, Tehran, Iran
چکیده [English]

 
The aim of this study was to examine the effect of 4 weeks of aerobic exercise on cognitive impairments and motor dysfunction in diabetic male rats. 24 adult male Wistar rats (weight 275±9.9 g, age 13 weeks) were purchased and randomly divided into three groups: sham, diabetic and diabetic + exercise. Diabetes was induced with intraperitoneal injection of one dose of streptozotocin (STZ) (60ml/kg). The diabetes criterion was the blood glucose level higher than 250 mg/dl. One week after the induction of diabetes, the rats in exercise group ran on a treadmill 5 days a week for 4 weeks (20-30 min. at 10-18 m/min). The passive avoidance memory test was used to assess the memory impairments. Inclined plane and barfix tests were used to assess motor function. Results showed that the exercise significantly reduced the diabetic-induced impairment in the short-term memory in passive avoidance memory test (P=0.0001) and increased the motor function in diabetic rats in inclined plane (P=0.017) and barfix (P=0.0001) tests. In general, it can be stated that 4 weeks of aerobic exercise improves cognitive impairments and motor dysfunction in streptozotocin-induced diabetic rats.

کلیدواژه‌ها [English]

  • cognitive impairment
  • diabetes
  • exercise
  • Streptozotocin
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