تأثیر دوازده هفته تمرینات یکپارچۀ حرکتی شناختی بر عامل نوروتروفیک مشتق از مغز (BDNF) سالمندان مبتلا به دمانس

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری تخصصی فیزیولوژی ورزش، دانشگاه رازی، کرمانشاه، ایران

2 استادیار گروه فیزیولوژی ورزش دانشگاه رازی، کرمانشاه، ایران

3 دانشیار گروه فیزیولوژی ورزش دانشگاه رازی، کرمانشاه، ایران

4 دکتری تخصصی فیزیولوژی ورزش، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، ایران

چکیده

 
هدف از تحقیق حاضر بررسی اثر تمرینات یکپارچۀ حرکتی شناختی بر BDNF سالمندان مبتلا به دمانس بود. بدین منظور، 24 مرد سالمند مبتلا به دمانس (12 نفر گروه تجربی و 12 نفر گروه کنترل) به‌عنوان نمونۀ آماری تحقیق انتخاب شدند. برنامۀ تمرینی یک دورۀ دوازده هفته‌ای (هفته‌ای سه جلسه تمرین 45 دقیقه‌ای) تمرینات حرکتی شناختی بود که براساس رهنمودهای کالج آمریکایی طب ورزش (ACSM) اتخاذ شد. پیش و پس از انجام پروتکل تمرینی میزان BDNF و آزمون‌های عملکردی و شناختی ارزیابی شد. به‌منظور تحلیل آماری از آنالیز تحلیل واریانس دوعاملی با اندازه‌های تکراری استفاده شد. یافته­های پژوهش نشان داد که 12 هفته برنامۀ تمرین حرکتی شناختی به افزایش سطوح BDNF (001/0=P)، بهبود نتایج آزمون رسیدن عملکردی (005/0=P)، آزمون بلند شدن و رفتن زمان‌دار (001/0=P)، آزمون تعادلی برگ (001/0=P) و آزمون کوتاه وضعیت ذهنی (015/0P=)، در گروه فعال منجر شد. به‌طور کلی یافته‌های مطالعه نشان داد که تمرین یکپارچۀ حرکتی در آزمودنی‌های مبتلا به دمانس، سبب افزایش سطوح BNDF می‌شود که از نظر بالینی این یافته‌ها اهمیت آمادگی بدنی به‌عنوان یک عامل پیشگیری‌کننده از ابتلا به زوال عقل در آینده را تأیید می‌کند. همچنین این نوع فعالیت، روش تمرینی سودمندی جهت حفظ عملکرد حرکتی و کاهش سرعت کارکردهای ذهنی سالمندان است.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 12 Weeks of Cognitive Motor Integrated Exercises on Brain-Derived Neurotrophic Factor (BDNF) in the Elderly with Dementia

نویسندگان [English]

  • Sedigheh Hosseinpour Delavar 1
  • Naser Behpour 2
  • Vahid Tadibi 3
  • Azam Ramezankhani 4
1 PhD Student in Exercise Physiology, Razi University, Kermanshah, Iran
2 Assistant Professor, Department of Exercise Physiology, Razi University, Kermanshah, Iran
3 Associate Professor, Department of Exercise Physiology, Razi University, Kermanshah, Iran
4 PhD in Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
چکیده [English]

 
The aim of the present study was to investigate the effect of cognitive motor integrated exercises on BDNF in the elderly with dementia. For this purpose, 24 male elderly with dementia (12 experimental and 12 control (were selected as the statistical sample. The program consisted of 12 weeks of (3 sessions per week, 45 minutes per session (cognitive motor exercises according to the guidelines of American College of Sport Medicine (ACSM). Before and after the exercise protocol, BDNF and cognitive and functional tests were evaluated. ANOVA with repeated measures was used for data analysis. The results showed that 12 weeks of cognitive motor protocol increased BDNF (P=0.001) and improved the results of functional reach test (P=0.005), timed up and go test (P=0.001), Berg balance scale (P=0.001) and mini–mental state examination (P=0.015) in the active group. In general, these findings showed that motor integrated exercise in the elderly with dementia increased BNDF levels. These findings clinically confirm the importance of physical fitness as a factor which prevents dementia in the future. Also, this type of activity is a beneficial training method to maintain motor function and to reduce the rate of mental functioning in the elderly.

کلیدواژه‌ها [English]

  • balance
  • Cognition
  • cognitive motor exercises
  • dementia
  • Elderly
  • neurotrophin
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