تأثیر فعالیت متناوب با شدت بالا در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ فاکتور رشد اِندوتلیال عروقی سرم در مردان غیرفعال

رواسی, علی اصغر; مهری الوار, یعقوب; احمدی زاده, سجاد; حسنوند, سجاد

doi:10.22059/jsb.2015.57280

نوع مقاله : مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I

نویسندگان

¹ استاد دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

² کارشناس‌ارشد فیزیولوژی و تغذیۀ ورزشی دانشگاه تهران، تهران، ایران

³ عضو هیأت علمی فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران

https://doi.org/10.22059/jsb.2015.57280

چکیده

هدف از پژوهش حاضر، بررسی تأثیر فعالیت متناوب با شدت بالا (HIE) در شرایط هایپوکسی و نورموکسی بر پاسخ VEGF سرم مردان غیرفعال است. به این منظور 9 مرد جوان غیرفعال (سن 5±50/24 سال، قد 6/4±22/174سانتی‌‌‌متر، وزن 5/4±75/70 کیلوگرم و حداکثر بازده کاری (Wmax) در شرایط هایپوکسی 04/29±185 و در شرایط نورموکسی 8/31±0/200) به‌عنوان آزمودنی انتخاب شدند. آزمودنی‌ها، پروتکل فعالیت متناوب با شدت بالا را در شرایط هایپوکسی نورموباریک (3/15 تا 5/15درصد اکسیژن تقریباً برابر ارتفاع 2500 متر) و همین پروتکل را در شرایط نورموکسی در دو هفتۀ مجزا اجرا کردند. نمونه‌های خونی قبل، بلافاصله و 2 ساعت پس از فعالیت گرفته شد. نتایج آزمون تحلیل واریانس با اندازه‌گیری‌های مکرر نشان داد که بین شرایط محیطی مختلف (هایپوکسی و نورموکسی)، در میزان اثرگذاری بر سطوح VEGF سرمی مردان غیرفعال اختلاف معنادار وجود ندارد (452/0P=). مداخلات تمرینی و مطالعات بسیاری برای مشخص شدن مویرگ‌زایی در بدن نیاز است؛ اگرچه سطوح بالای VEGF پس از فعالیت متناوب با شدت بالا ممکن است به افزایش آنژیوژنز و مویرگ‌زایی منجر شود. به هر حال برای مشخص شدن محرک‌ها و سازوکارهایی که برای رشد عروق جدید در تمرینات با شدت بالا گزارش شده، به تحقیقات بیشتری نیاز است.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of High Intensity Intermittent Exercise (HIE) in Hypoxia and Normoxia on Response of Vascular Endothelial Growth Factor in nNon-Athletic Men

نویسندگان [English]

Aliasghar Ravasi ¹
Yaghob Mehrialvar ²
Sajad Ahmadizade ³
Sajad Hasanvand ²

¹ Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

² Master of Science Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

³ . Assistant Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Shahid Beheshti , Tehran, Iran

چکیده [English]

The purpose of present research was to investigate the effect of high-intensity interval exercise (HIE) in hypoxia and normoxia conduction on response of serum VEGF in inactive men. To this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (W max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects. Subjects performed protocol of high-intensity exercise in normobaric normoxia conduction (%15/3-15/5 O₂altitude of approximately 2500 m) and hypoxia in two separate weeks. Blood samples was taken immediately before and 2 hours after exercise. The ANOVA technique with repeated measures was used to analyze the data(P=0/452). Training interventions and a lot study are needed to determine angiogenesis in human body. Although high levels of VEGF after high-intensity exercise may be leading to increased angiogenesis. However, future studies are needed to determine the drivers and mechanisms that have been reported for new vascular growth in high-intensity exercise.

کلیدواژه‌ها [English]

angiogenesis
high-intensity intermittent exercise
hypoxia
vascular endothelial growth factor

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نشریه علوم زیستی ورزشی

تأثیر فعالیت متناوب با شدت بالا در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ فاکتور رشد اِندوتلیال عروقی سرم در مردان غیرفعال

مراجع

مراجع

دوره 7، شماره 4 - شماره پیاپی 4
دی 1394
صفحه 519-540

تأثیر فعالیت متناوب با شدت بالا در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ فاکتور رشد اِندوتلیال عروقی سرم در مردان غیرفعال

مراجع

مراجع

دوره 7، شماره 4 - شماره پیاپی 4دی 1394صفحه 519-540

دوره 7، شماره 4 - شماره پیاپی 4
دی 1394
صفحه 519-540