نشریه علوم زیستی ورزشی

تأثیر فعالیت متناوب با شدت بالا در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ فاکتور رشد اِندوتلیال عروقی سرم در مردان غیرفعال

نوع مقاله : مقاله پژوهشی

نویسندگان

علی اصغر رواسی 1
یعقوب مهری الوار 2
سجاد احمدی زاده 3
سجاد حسنوند 2

1 استاد دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

2 کارشناس‌ارشد فیزیولوژی و تغذیۀ ورزشی دانشگاه تهران، تهران، ایران

3 عضو هیأت علمی فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران

https://doi.org/10.22059/jsb.2015.57280
چکیده
هدف از پژوهش حاضر، بررسی تأثیر فعالیت متناوب با شدت بالا (HIE) در شرایط هایپوکسی و نورموکسی بر پاسخ VEGF سرم مردان غیرفعال است. به این منظور 9 مرد جوان غیرفعال (سن 5±50/24 سال، قد 6/4±22/174سانتی‌‌‌متر، وزن 5/4±75/70 کیلوگرم و حداکثر بازده کاری (Wmax) در شرایط هایپوکسی 04/29±185 و در شرایط نورموکسی 8/31±0/200) به‌عنوان آزمودنی انتخاب شدند. آزمودنی‌ها، پروتکل فعالیت متناوب با شدت بالا را در شرایط هایپوکسی نورموباریک (3/15 تا 5/15درصد اکسیژن تقریباً برابر ارتفاع 2500 متر) و همین پروتکل را در شرایط نورموکسی در دو هفتۀ مجزا اجرا کردند. نمونه‌های خونی قبل، بلافاصله و 2 ساعت پس از فعالیت گرفته شد. نتایج آزمون تحلیل واریانس با اندازه‌گیری‌های مکرر نشان داد که بین شرایط محیطی مختلف (هایپوکسی و نورموکسی)، در میزان اثرگذاری بر سطوح VEGF سرمی مردان غیرفعال اختلاف معنادار وجود ندارد (452/0P=). مداخلات تمرینی و مطالعات بسیاری برای مشخص شدن مویرگ‌زایی در بدن نیاز است؛ اگرچه سطوح بالای VEGF پس از فعالیت متناوب با شدت بالا ممکن است به افزایش آنژیوژنز و مویرگ‌زایی منجر شود. به هر حال برای مشخص شدن محرک‌ها و سازوکارهایی که برای رشد عروق جدید در تمرینات با شدت بالا گزارش شده، به تحقیقات بیشتری نیاز است.
 
 
 

کلیدواژه‌ها

آنژیوژنز
فاکتور رشد اندوتلیال عروقی
فعالیت تناوبی با شدت بالا
هیپوکسی

عنوان مقاله English

The Effect of High Intensity Intermittent Exercise (HIE) in Hypoxia and Normoxia on Response of Vascular Endothelial Growth Factor in nNon-Athletic Men

نویسندگان English

Aliasghar Ravasi 1
Yaghob Mehrialvar 2
Sajad Ahmadizade 3
Sajad Hasanvand 2
1 Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
2 Master of Science Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
3 . Assistant Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Shahid Beheshti , Tehran, Iran
چکیده English

The purpose of present research was to investigate the effect of high-intensity interval exercise (HIE) in hypoxia and normoxia conduction on response of serum VEGF in inactive men. To this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (W max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects. Subjects performed protocol of high-intensity exercise in normobaric normoxia conduction (%15/3-15/5 O2 altitude of approximately 2500 m) and hypoxia in two separate weeks. Blood samples was taken immediately before and 2 hours after exercise. The ANOVA technique with repeated measures was used to analyze the data(P=0/452). Training interventions and a lot study are needed to determine angiogenesis in human body. Although high levels of VEGF after high-intensity exercise may be leading to increased angiogenesis. However, future studies are needed to determine the drivers and mechanisms that have been reported for new vascular growth in high-intensity exercise.
 
 
 
 
 

کلیدواژه‌ها English

angiogenesis
high-intensity intermittent exercise
hypoxia
vascular endothelial growth factor

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  • تاریخ دریافت 22 اسفند 1391
  • تاریخ بازنگری 08 اردیبهشت 1395
  • تاریخ پذیرش 05 مرداد 1392

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