The effect of high intensity intermittent exercise (HIE) in Hypoxia and normoxia on response of Vascular Endothelial Growth Factor in non-athletic men

Document Type : Research Paper


1 Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 Master of Science Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 . Assistant Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Shahid Beheshti , Tehran, Iran


The purpose of present research was to investigate the effect of high-intensity interval exercise (HIE) in hypoxia and normoxia conduction on response of serum VEGF in inactive men. To this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (W max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects. Subjects performed protocol of high-intensity exercise in normobaric normoxia conduction (%15/3-15/5 O2 altitude of approximately 2500 m) and hypoxia in two separate weeks. Blood samples was taken immediately before and 2 hours after exercise. The ANOVA technique with repeated measures was used to analyze the data(P=0/452). Training interventions and a lot study are needed to determine angiogenesis in human body. Although high levels of VEGF after high-intensity exercise may be leading to increased angiogenesis. However, future studies are needed to determine the drivers and mechanisms that have been reported for new vascular growth in high-intensity exercise.



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