نشریه علوم زیستی ورزشی

تأثیر هشت هفته تمرین هوازی بر برخی از micro RNAs مرتبط با ناهنجاری‌های عروقی و مقاومت به انسولین در مردان مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی

نویسندگان

سیاوش ساغری 1
داریوش شیخ الاسلامی وطنی 2

1 گروه تربیت بدنی وعلوم ورزشی،دانشکده علوم انسانی و اجتماعی،دانشگاه کردستان، سنندج،ایران.

2 گروه علوم ورزشی،دانشگاه کردستان، سنندج،ایران

10.22059/jsb.2025.385184.1666
چکیده
مقدمه: دیابت شایع‌ترین بیماری غدد در جهان و مسئول حدود چهار میلیون مرگ در سال است. پژوهش حاضر با هدف بررسی تأثیر هشت هفته تمرین هوازی بر برخی از micro RNAs مرتبط با ناهنجاری‌های عروقی و مقاومت به انسولین در مردان مبتلا به دیابت نوع دو انجام شد.
روش پژوهش: 40 مرد مبتلا به دیابت نوع دو (با میانگین سن 1/2 ± 2/49 سال) شهر کرمانشاه به‌عنوان نمونه در نظر گرفته شدند و به‌صورت تصادفی در دو گروه تمرین هوازی و کنترل قرار گرفتند. برنامۀ تمرین هوازی به‌صورت تناوبی فزاینده به مدت هشت هفته و هر هفته سه جلسه و با شدت 60 تا 70 درصد ضربان قلب بیشینه اجرا شد (خون‌گیری 48 ساعت پیش از اولین جلسۀ تمرین و 48 ساعت پس از اتمام جلسات تمرینی انجام گرفت). سطوح پلاسمایی miR-222، miR-221، miR-21 از طریق روش PCR-Realtime اندازه‌گیری شد. تجزیه‌وتحلیل داده‌ها با استفاده از آزمون‌های تی وابسته و تی مستقل در سطح 05/0≥P انجام گرفت.
یافته‌ها: هشت هفته تمرینات هوازی تأثیر معنا‌داری بر سطوح (003/0miR-21(P=، (001/0miR-221(P= و)001/0 miR-222(p=مردان مبتلا به دیابت نوع دو داشت. همچنین تفاوت معناداری بین میانگین تغییرات دو گروه در خصوص هر سه متغیر به نفع گروه تجربی وجود داشت (در هر سه مورد، 001/0P=).
نتیجه‌گیری: نتایج این تحقیق نشان داد که هشت هفته تمرین هوازی سبب افزایش عوامل آنژیوژنز در مردان مبتلا به دیابت نوع دو می‌شود.

کلیدواژه‌ها

تمرین هوازی
دیابت نوع دو
آنژیوژنز
Micro RNAs
موضوعات

عنوان مقاله English

The Effect of Eight Weeks of Aerobic Training on Some Micro RNAs Associated with Vascular Abnormalities and Insulin Resistance in Men with Type 2 Diabetes

نویسندگان English

Siavash Saghari 1
Dariush Sheikholeslam Vatani 2
1 .Department of Physical Education and Sports Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
2 Department of Sports Sciences, University of Kurdistan, Sanandaj, Iran.
چکیده English

Introduction: Diabetes mellitus is the most prevalent endocrine disorder worldwide and is responsible for approximately 4 million deaths annually. The present study aimed to investigate the effect of eight weeks of aerobic training on certain microRNAs associated with vascular dysfunction and insulin resistance in men with type 2 diabetes.
Methods: A sample of 40 men with type 2 diabetes (mean age: 49.2 ± 2.1 years) from Kermanshah city were selected and randomly assigned into two groups: an aerobic exercise group and a control group. The aerobic exercise protocol consisted of progressively increasing intervals over eight weeks, with three sessions per week at an intensity of 60-70% of maximum heart rate. Blood samples were collected 48 hours before the first training session and 48 hours after the final training session. Plasma levels of miR-222, miR-221, and miR-21 were measured using the real-time PCR technique. Data were analyzed using paired and independent t-tests, with statistical significance set at p ≤ 0.05.
Results: Eight weeks of aerobic training significantly affected the levels of miR-221 (p = 0.001), miR-222 (p = 0.001), and miR-21 (p = 0.003) in men with type 2 diabetes. Moreover, a significant difference was observed between the two groups in the mean changes of all three microRNAs, favoring the exercise group (p = 0.001 for all comparisons).
Conclusion: The findings of this study indicate that eight weeks of aerobic training increases angiogenic factors in men with type 2 diabetes.

کلیدواژه‌ها English

Aerobic exercise
Angiogenesis
Diabetes Type 2
MicroRNAs
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نشریه علوم زیستی ورزشی
دوره 17، شماره 2
تابستان
تابستان 1404
صفحه 93-107

  • تاریخ دریافت 19 آذر 1403
  • تاریخ بازنگری 09 مهر 1404
  • تاریخ پذیرش 21 مهر 1404

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