Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
1 .Department of Physical Education and Sports Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
2 Department of Sports Sciences, University of Kurdistan, Sanandaj, Iran.
Abstract
Introduction: Diabetes mellitus represents the most prevalent endocrine disorder globally, accounting for approximately 4 million fatalities annually. This study aimed to explore the impact of an eight-week aerobic exercise regimen on specific microRNAs associated with vascular dysfunction and insulin resistance in males diagnosed with type 2 diabetes.
Methods: A sample of 40 male participants with type 2 diabetes (mean age of 49.2 ± 2.1 years) from Kermanshah city was selected and randomly divided into two groups: one engaging in aerobic exercise and a control group. The aerobic exercise protocol consisted of progressively increasing intervals over eight weeks, with three sessions per week, maintaining an intensity of 60 to 70% of the maximum heart rate. Blood samples were collected 48 hours prior to the initial training session and 48 hours following the completion of the exercise program. The plasma levels of miR-222, miR-221, and miR-21 were quantified using the PCR-Realtime technique. Statistical analysis was performed utilizing t-tests and independent t-tests, with significance set at p≤0.05.
Results: The eight-week aerobic training significantly influenced the levels of miR-221 (p=0.001), miR-222 (p=0.001), and miR-21 (p=0.003) in the male participants with type 2 diabetes. Furthermore, a significant difference was observed in the average changes of all three microRNAs between the experimental and control groups, favoring the experimental group (p=0.001 for all comparisons).
Conclusion: The findings of this study indicate that an eight-week aerobic exercise program enhances angiogenic factors in men suffering from type 2 diabetes.
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