Introduction: The aim of this study was to determine the effect of HIIT with coenzyme Q10 supplementation on BMP-6 growth in obese male rats. Therefore, the aim of this study was to determine the effect of HIIT along with coenzyme Q10 supplementation on BMP-6 growth in obese male rats.

Methods: 30 male Wistar rats were randomly divided into 6 groups including 1) lean reference, 2) obese reference, 3) obese control, 4) obese supplement, 5) obese exercise and 6) exercise+obese supplement. The lean reference and obese reference groups were sacrificed at the beginning of the study. The training groups underwent HIIT program for 12 weeks. 500 mg/kg of coenzyme Q10 supplement was gavage to the rats of the supplemented groups. BMP-6 levels in blood were measured using ELISA method. The data was analyzed using one-way analysis of variance.

Results: The values of BMP-6 decreased in the obese training group compared to the lean reference group (p<0.001) and increased compared to the obese control group (p=0.032), decreased in the obese supplement group compared to the lean reference group(p<0.001), and significantly decreased in the exercise+obese supplement group compared to the lean reference group (p<0.001). However, no significant difference was observed between the three obese supplement groups, obese reference and obese control(p>0.05).

Conclusion: 12 weeks of HIIT leads to a significant increase in BMP-6 levels in obese samples. However, the administration of coenzyme Q10 alone or together with HIIT for 12 weeks does not lead to a significant increase in BMP-6 levels.