Document Type : Research Paper
Assistance Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran
۲. استاد، دانشکدۀ تربیت بدنی و علوم ورزشی دانشگاه تهران
Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran 4. PhD in Exercise Physiology, Tehran
phd graduate university of mazandaran
The aim of the present study was to investigate the effect of a period of progressive resistance training on muscle mass and muscular oxidative - antioxidative markers in diabetic rats. In an experimental study, 24 Wistar rats were divided into two groups: resistance training (n=12) and control (n=12). Diabetes was induced by single-dose injection of streptozotocin (50 mg/kg of body weight, intra protaneal, dissolved in phosphate buffer). Training group performed resistance training for 8 weeks, 3 sessions per week. 48 hours after the last training session, animals were anesthetized and blood was taken from the heart; then, the flexor hallucis longus muscle (FHL) was removed from the lower limb. Independent samples t test was used to compare the groups. In resistance training group, FHL muscle mass and FHL muscle mass / body weight ratio were significantly higher than the control group (P=0.002 and P=0.033 respectively). Level of MDA in FHL muscle of resistance training group was 12.2% higher than the control group, but the difference between the groups was not statistically significant (P=0.176). Protein Carbonyl (PC) level of FHL muscle in training group was 26% lower than the control group but the difference between the groups was not statistically significant (P=0.062). Moreover, findings showed that total glutathione content (T-GSH) of FHL muscle in training group was 36.8% higher than the control group (P<0.001). The observed increase in muscle mass along with improvements in T-GSH content and PC suggests that resistance training decreased muscle oxidative stress and can have beneficial antiatrophy effects in diabetes.