The Effect of Progressive Resistance Training on Muscle Mass and Oxidative - Antioxidative Markers in Muscle Tissue of Diabetic Rats

Document Type : Research Paper


1 Assistance Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran

2 ۲. استاد، دانشکدۀ تربیت بدنی و علوم ورزشی دانشگاه تهران

3 Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran 4. PhD in Exercise Physiology, Tehran

4 phd graduate university of mazandaran


The aim of the present study was to investigate the effect of a period of progressive resistance training on muscle mass and muscular oxidative - antioxidative markers in diabetic rats. In an experimental study, 24 Wistar rats were divided into two groups: resistance training (n=12) and control (n=12). Diabetes was induced by single-dose injection of streptozotocin (50 mg/kg of body weight, intra protaneal, dissolved in phosphate buffer). Training group performed resistance training for 8 weeks, 3 sessions per week. 48 hours after the last training session, animals were anesthetized and blood was taken from the heart; then, the flexor hallucis longus muscle (FHL) was removed from the lower limb. Independent samples t test was used to compare the groups. In resistance training group, FHL muscle mass and FHL muscle mass / body weight ratio were significantly higher than the control group (P=0.002 and P=0.033 respectively). Level of MDA in FHL muscle of resistance training group was 12.2% higher than the control group, but the difference between the groups was not statistically significant (P=0.176). Protein Carbonyl (PC) level of FHL muscle in training group was 26% lower than the control group but the difference between the groups was not statistically significant (P=0.062). Moreover, findings showed that total glutathione content (T-GSH) of FHL muscle in training group was 36.8% higher than the control group (P<0.001). The observed increase in muscle mass along with improvements ​​in T-GSH content and PC suggests that resistance training decreased muscle oxidative stress and can have beneficial antiatrophy effects in diabetes.


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