TY - JOUR ID - 64717 TI - The Effect of Progressive Resistance Training on Muscle Mass and Oxidative - Antioxidative Markers in Muscle Tissue of Diabetic Rats JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - Samadi, Ali AU - Gaeni, Abass ali AU - Ravasi, Ali asghar AU - Khalesi, Maryam AD - Assistance Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran AD - ۲. استاد، دانشکدۀ تربیت بدنی و علوم ورزشی دانشگاه تهران AD - Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran 4. PhD in Exercise Physiology, Tehran AD - phd graduate university of mazandaran Y1 - 2017 PY - 2017 VL - 9 IS - 3 SP - 301 EP - 314 KW - diabetes KW - oxidative stress KW - resistance training DO - 10.22059/jsb.2017.43174.684 N2 - The aim of the present study was to investigate the effect of a period of progressive resistance training on muscle mass and muscular oxidative - antioxidative markers in diabetic rats. In an experimental study, 24 Wistar rats were divided into two groups: resistance training (n=12) and control (n=12). Diabetes was induced by single-dose injection of streptozotocin (50 mg/kg of body weight, intra protaneal, dissolved in phosphate buffer). Training group performed resistance training for 8 weeks, 3 sessions per week. 48 hours after the last training session, animals were anesthetized and blood was taken from the heart; then, the flexor hallucis longus muscle (FHL) was removed from the lower limb. Independent samples t test was used to compare the groups. In resistance training group, FHL muscle mass and FHL muscle mass / body weight ratio were significantly higher than the control group (P=0.002 and P=0.033 respectively). Level of MDA in FHL muscle of resistance training group was 12.2% higher than the control group, but the difference between the groups was not statistically significant (P=0.176). Protein Carbonyl (PC) level of FHL muscle in training group was 26% lower than the control group but the difference between the groups was not statistically significant (P=0.062). Moreover, findings showed that total glutathione content (T-GSH) of FHL muscle in training group was 36.8% higher than the control group (P<0.001). The observed increase in muscle mass along with improvements ​​in T-GSH content and PC suggests that resistance training decreased muscle oxidative stress and can have beneficial antiatrophy effects in diabetes. UR - https://jsb.ut.ac.ir/article_64717.html L1 - https://jsb.ut.ac.ir/article_64717_4d79f2ceb076a39a6ea8a03ca45550d0.pdf ER -