Introduction: Infection in infancy increases the level of anxiety. The aim of this study was to evaluate the effect of a course of swimming exercises and minocycline medication after childhood infection on the level of anxiety and malondialdehyde levels in the hippocampus and peripheral cortex of NMRI mice.
Methods: In order to induce infection, on the third and fifth day after birth, the animals received lipopolysaccharide for 15 days. Animals were divided into 5 groups, consist of control, LPS; LPS+ Min; LPS + Ex and LPS+ Ex +Min were divided. The duration of the course was 4 weeks and the dose of minocycline was 20 mg/kg. The Open Field test anxiety was used to measure anxiety levels. One-way ANOVA with Tukey's post hoc test at a significance level of 0.05 was used.
Results: MDA levels in the LPS group were the highest in both the hippocampus and prefrontal sections compared to the Control group (P ≥ 0.05). The percentage of hippocampal MDA changes in the LPS+Min+EX group decreased by 14% compared to the control group, and the prefrontal MDA of the LPS+Min+EX group increased by 20% compared to the control group. So that the elapsed time and the number of entries in the Open Field test were increased in the LPS+Min+Ex group compared to other groups and decreased in the LPS group (P ≤ 0.05).
Conclusion: The results showed that swimming exercise and minocycline can change the effects of anxiety caused by childhood infection with changes in MDA.