The effect of 8 weeks High Intensity Interval Training on Serum levels of Asprosin, Insulin and Insulin Resistance Index in Diabetic Rats

Document Type : Research Paper I Open Access I Released under CC BY 4.0 license


1 Sport Physiology, Physical Education, Tehran University, Tehran, Iran.

2 Sport Physiology, Physical Education, Ferdosi University, Mashhad, Iran.


Type 2 diabetes is a risk factor for heart disease and has a major contribution in mortality due to cardiovascular diseases. In diabetics people, high levels of glucose is a very important issue that should be controlled. In the present study, the effect of 8-week HIIT was investigated on Serum levels of Asprosin, insulin, and insulin resistance index in diabetic rats. In this Investigation, A total of 32 male Wistar rats (mean weight, 180/23±7gr) were randomly divided into four groups of Healthy control (N=8), diabetic control (N= 8), Healthy training (N= 8) and Diabetic training (N= 8). The training group performed a 8-week High Intensity Interval Training, and 48 hours after the end of the last training session, the rats were anesthetized and euthanized. The variables of interest (Serum Levels of Asprosin, level of glucose, insulin, and insulin resistance index), were measured. Data analysis was performed using Kruskal–Wallis at significance level of p≤0.05.
There was a significant difference among Asprosin (p>0/001), level of glucose (p>0/001), insulin (p>0/026), and Insulin Resistance Index (p>0/001) between the Healthy control Group, diabetic control Group, Healthy training Group and Diabetic training Group. According to the results of the present study, it seems that High Interval Intensity Training is an important strategy to decrease Asprosin, plasma glucose and Insulin resistance index in diabetics rat and it can be considered as an effective intervention method for treatment diabetes.


Volume 13, Issue 2
September 2021
Pages 167-177
  • Receive Date: 18 May 2018
  • Revise Date: 11 August 2018
  • Accept Date: 21 August 2018
  • First Publish Date: 23 August 2021