Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
1 Sport Physiology, Physical Education, Tehran University, Tehran, Iran.
2 Sport Physiology, Physical Education, Ferdosi University, Mashhad, Iran.
Type 2 diabetes is a risk factor for heart disease and has a major contribution in mortality due to cardiovascular diseases. In diabetics people, high levels of glucose is a very important issue that should be controlled. In the present study, the effect of 8-week HIIT was investigated on Serum levels of Asprosin, insulin, and insulin resistance index in diabetic rats. In this Investigation, A total of 32 male Wistar rats (mean weight, 180/23±7gr) were randomly divided into four groups of Healthy control (N=8), diabetic control (N= 8), Healthy training (N= 8) and Diabetic training (N= 8). The training group performed a 8-week High Intensity Interval Training, and 48 hours after the end of the last training session, the rats were anesthetized and euthanized. The variables of interest (Serum Levels of Asprosin, level of glucose, insulin, and insulin resistance index), were measured. Data analysis was performed using Kruskal–Wallis at significance level of p≤0.05.
There was a significant difference among Asprosin (p>0/001), level of glucose (p>0/001), insulin (p>0/026), and Insulin Resistance Index (p>0/001) between the Healthy control Group, diabetic control Group, Healthy training Group and Diabetic training Group. According to the results of the present study, it seems that High Interval Intensity Training is an important strategy to decrease Asprosin, plasma glucose and Insulin resistance index in diabetics rat and it can be considered as an effective intervention method for treatment diabetes.
2. Pedersen, B.K., Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. European Journal of Clinical Investigation, 2017. 47(8): p. 600-611.
3. Hu, G., et al., Exercise, genetics and prevention of type 2 diabetes. Essays in Biochemistry, 2006. 42: p. 177-192.
4. Weight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women. Annals of Internal Medicine, 1995. 122(7): p. 481-486.
5. Lim, E.L., et al., Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia, 2011. 54(10): p. 2506-2514.
6. Tatemoto, K., et al., Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor. Biochemical and Biophysical Research Communications, 1998. 251(2): p. 471-476.
7. O'Neill, B., et al., Body fat distribution and metabolic variables in patients with neonatal progeroid syndrome. American Journal of Medical Genetics Part A, 2007. 143A(13): p. 1421-1430.
8. Milewicz, D.M., et al., A mutation in FBN1 disrupts profibrillin processing and results in isolated skeletal features of the Marfan syndrome. The Journal of clinical investigation, 1995. 95(5): p. 2373-2378.
9. Bindlish, S., L.S. Presswala, and F. Schwartz, Lipodystrophy: Syndrome of severe insulin resistance. Postgraduate Medicine, 2015. 127(5): p. 511-516.
10. Goldblatt, J., et al., Further evidence for a marfanoid syndrome with neonatal progeroid features and severe generalized lipodystrophy due to frameshift mutations near the 3′ end of the FBN1 gene. American Journal of Medical Genetics Part A, 2011. 155(4): p. 717-720.
11. Jacquinet, A., et al ,.Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3′ end of FBN1 gene. European Journal of Medical Genetics, 2014. 57(5): p. 230-234.
12. Romere, C., et al., Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell, 2016. 165(3): p. 566-579.
13. Wang, Y., et al., Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion. Mediators of Inflammation, 2018. 2018: p. 9471583.
14. Zhang, L., et al., Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride. Clinica Chimica Acta, 2019. 489: p. 183-188.
15. Salehi, O.R. and A. Hoseini, The effects of endurance trainings on serum BDNF and insulin levels in streptozotocin-induced diabetic rats. Shefaye Khatam, 2017. 5(2): p. 52-61.
16. Fathi, M., R. Gharakanlou, and R. Rezaei, The effect of endurance training on left ventricle serum response factor gene expression in Wistar male rats. Journal of Shahrekord Uuniversity of Medical Sciences, 2015. 17(1): p. 78-86.
17. Andrade-Oliveira, V., N.O.S. Câmara, and P.M. Moraes-Vieira, Adipokines as Drug Targets in Diabetes and Underlying Disturbances. Journal of Diabetes Research, 2015. 2015: p. 681612.
18. Patel, J.V., et al., Circulating serum adiponectin levels in patients with coronary artery disease: relationship to atherosclerotic burden and cardiac function. Journal of Internal Medicine, 2008. 264(6): p. 593-598.
19. Yu, N., et al., Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals. Horm Metab Res, 2017. 49(03 :( p. 164-173.
20. Boudou, P., et al., Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. European journal of endocrinology, 2003. 149(5): p. 421-424.
21.Chang, Y.-H., et al., Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review. Diabetes/Metabolism Research and Reviews, 2011. 27(6): p. 515-527.
22.Ghanbarzadeh, M. and M. Omidi, The Effects of Physical Activity on Serum Visfatin Level: A Literature Review. Int J Basic Sci Med, 2017. 2(2): p. 83-89.