The Effect of Aerobic and Resistance Training on Some Coagulation (PAI-1, Fibrinogen, PT, PTT) and Fibrinolysis (t-PA, Plasminogen and D-Dimer) Factors in Sedentary Obese Women

Document Type : Research Paper


1 PhD of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran

2 Associate Professor of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran

3 . Assistant Professor of Biotechnology, Department of Medicinal Plants, Nahavand University, Nahavand, Iran

4 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran


Obesity contributes to disrupt balance between coagulation (increasing) and fibrinolysis (decreasing) factors and is effective in inducing thrombosis. Physical activities play a role in controlling the damages caused by obesity. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic and resistance training on PAI-1, fibrinogen, PT, PTT, t-PA, plasminogen and D-dimer. 30 sedentary women (age: 25-30 years, body mass index: 30 Kg/m2) voluntarily participated in this study and were randomly divided into three groups: aerobic training, resistance training and control. Aerobic training was performed 3 sessions a week, 30-45 minutes each session with an intensity of 60-85% of maximum heart rate. Resistance training was performed based on 10RM, following the principle of overload for 8 weeks. Data were analyzed by ANOVA and dependent t test (P<0.5). Aerobic training significantly increased tPA compared to control and resistance training groups (P=0.001). Both resistance and aerobic training significantly increased prothrombin time (PT), PAI-1, plasminogen and D-dimer (P=0.001) compared to the control group. Aerobic training significantly increased (P=0.001) and resistance training significantly decreased (P=0.003) fibrinogen compared to the control group. The partial thromboplastin time (PTT) increased in the resistance training group (P=0.03) and decreased in aerobic training group (P=0.001) compared to the control group. Aerobic training has a better effect on important fibrinolysis factors including t-PA, while resistance training has a better control on some important coagulation variables including fibrinogen


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