The Effect of Moderate Continuous Training on TRPV1 Protein Expression in Slow-Contraction Muscles of Wistar Rats

Document Type : Research Paper


1 PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

2 . Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

3 Associate Professor, Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran


The vanilloid receptor 1 (TRPV1) is a nociceptor receptor in sensitive system which is activated by capsaicin, heat, acidity and some metabolites. The role of this cation receptor is known at pain. New reports suggest that TRPV1 plays a role in other processes and researchers are studying the effect of this receptor on exercise pressure reflex (EPR) and cardiovascular response in some diseases.  In this experimental study, the aim of this study was to find an appropriate answer to perceive the effect of moderate continuous training on the expression of TRPV1 protein in soleus muscle. 16 male Wistar rats (weight: 200-220 gr) were randomly assigned to 2 groups: training and control. The training group performed 6 weeks (5 sessions per week) of moderate continuous training. The control group did not have any training but there was no difference between these groups in all conditions. The rats were anesthetized, sacrificed and their required tissues were extracted by standard procedures. The results of independent t test derived from Western Blotting laboratory findings for TRPV1 receptor protein expression showed a significant increase (P=0.033) in the expression of this receptor in soleus muscle in the training group compared with the control group. These results show that sensory nerves are adapted to training with an increase in TRPV1 receptor protein expression.


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