A Comparison of the Effect of 12 Weeks of Interval Training with High and Moderate Intensity on Perilipin 3 of Visceral Adipose Tissue and Insulin Resistance in Type 2 Diabetic Male Rats

Moghaddami, Kamilia; Mohebbi, Hamid; Tabari, Elma; Faridnia, Mehrsa

doi:10.22059/jsb.2018.261519.1289

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ PhD Student of Exercise Physiology, University Campus, Guilan University, Rasht, Iran

² Professor, Faculty of Physical Education and Sport Sciences, Guilan University, Rasht, Iran

³ PhD Student of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Guilan University, Rasht, Iran

https://doi.org/10.22059/jsb.2018.261519.1289

Abstract

The aim of this study was to compare the effect of 12 weeks of interval training with high and moderate intensity on perilipin 3 (PLIN3) of visceral adipose tissue and insulin resistance in type 2 diabetic male rats. In this study, 24 male rats with type 2 diabetes were randomly divided into three groups: interval training with moderate intensity (MIIT), interval training with high intensity (HIIT) and control. Interval training (HIIT, MIIT) was applied for 12 weeks, 5 sessions per week. The MIIT protocol included 13 four-min. bouts of activity with intensity of 65-70% vo_2max and the HIIT protocol included 10 four-min. bouts of activity with intensity of 85-90% vo_2max with 2-minute active rest periods. Western Blot method was used to measure PLIN3 protein levels. ANOVA and Tukey's test were used for data analysis. The results indicated a significant decrease in PLIN3 in the HIIT and MIIT groups compared with the control group (P=0.001). However, there was no significant difference between the training groups (P=0.274). Also, both HIIT and MIIT protocols significantly decreased serum levels of glucose (P=0.001), while they had no significant effects on serum insulin and insulin resistance (P˃0.05). There was no significant difference between training groups in insulin, glucose and insulin resistance changes (P˃0.05). The findings of this study showed that both HIIT and MIIT protocols drastically reduced PLIN3 of visceral adipose and improved glucose metabolism in type 2 diabetic rats. Therefore, it seems that PLIN3 changes in visceral adipose are independent of the training intensity.

Keywords

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Journal of Sport Biosciences

A Comparison of the Effect of 12 Weeks of Interval Training with High and Moderate Intensity on Perilipin 3 of Visceral Adipose Tissue and Insulin Resistance in Type 2 Diabetic Male Rats

References

References

Volume 11, Issue 1
June 2019
Pages 35-48

A Comparison of the Effect of 12 Weeks of Interval Training with High and Moderate Intensity on Perilipin 3 of Visceral Adipose Tissue and Insulin Resistance in Type 2 Diabetic Male Rats

References

References

Volume 11, Issue 1June 2019Pages 35-48

Volume 11, Issue 1
June 2019
Pages 35-48