Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.

2 Professor of exercise Physiology, Faculty of physical education and sport sciences, University of Tehran, Tehran, Iran.

3 Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran


Angiogenesis is a vital process in growth and development of tissues, especially muscle tissues that is affected by muscle contraction. Different training modalities can affect the balance between angiogenic and angiostatic factors. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic and resistance training on vascular endothelial growth factor (VEGF) and endostatin (ES) in sedentary women. 30 sedentary women were randomly assigned to 3 groups: aerobic, resistance and control. Resistance training was performed for 8 weeks, 3 sessions per week and three 10-repetiton sets with intensity of 60-70% of 1RM for 9 movements. Aerobic training was performed for 8 weeks, 3 sessions per week, 30 minutes each session with intensity of 65-70% of maximum heart rate. Blood samples were collected 48 hours before and after the last training session in the fasting state. VEGF and ES values were measured using ELISA kit. Data were analyzed by dependent t test and ANOVA at (P<0.05). Intra-group results showed that aerobic and resistance training significantly increased serum levels of VEGF and significantly decreased ES. Also, the results of ANOVA and Tukey post hoc test revealed no significant difference in the amounts of VEGF and ES between resistance and aerobic training (P>0.05). The results of this study showed that resistance training could have the same effects as endurance training in the control and positive balance of angiogenesis


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