vascular endothelial growth factor receptor-2 and the pulmonary vascular volume Tracking, after 6 weeks of high-intensity interval training

Document Type : Research Paper


1 Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran

2 Assistant Professor, PhD of Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

3 . PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran


VEGF-2 has most potent angiogenic signaling associated with VEGF that So far,no has been published research in relation to the effect of exercise training on the vascular volume and it, in the lung . therefore, present study aim was investigate the effect of an high-intensity interval training period on VEGFR-2 expression and pulmonary vascular volume in male Wistar rats. This research including the experimental studies that samples its had formed 10 male Wistar rats,that to form of Randomly and equally were divided into training and control groups. Training program Was started with 25 meters per minute and with 70 meters per minute was Finished at the end of the period. In each training session, rats completed the 1-min activity with 10 repetition and work to rest ratio was 1:2. In the end, lung tissue extracted for stereologicaly and Immunohistochemistry tests. Statistical analysis whit Independent t-test, and Pearson correlation coefficient showed, significantly increase in VEGFR-2(sig: 0/001) and pulmonary vascular volume(sig: 0/042) in the exercise group compared to the control group, and positive correlation between changes in these two indicators whit exercise(sig: 0/035). In general it seems that 6 weeks of high-intensity interval training has potential to promote of lung angiogenic processes.


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