Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 PhD Student of Exercise Physiology, Mazandaran University, Babolsar, Iran

2 Associate Professor, Mazandaran University, Babolsar, Iran

3 MSc of Physical Education, University of Tehran, Tehran, Iran


The aim of this study was to examine the effect of swimming submaximal training and cadmium consumption on cardiac HIF1-α and vascular endothelial growth factor (VEGF) in pregnant rats. 32 pregnant Wistar rats were randomly divided into 4 groups: cadmium, swimming, cadmium+swimming and control. Experimental groups performed the swimming protocol for 3 weeks, 5 sessions a week for 60 minutes per session. The cadmium administrated by cadmium chloride dissolved in water was consumed by cadmium and cadmium+ swimming groups. The levels of cardiac HIF1-α and VEGF were analyzed by ELIZA method. The results showed that cadmium administration alone and/or with swimming significantly increased HIF1-α and VEGF (P=0.001). Swimming alone significantly decreased HIF1-α while it significantly increased VEGF (P=0.001). A combination of swimming and cadmium consumption decreased the cadmium effects on HIF1-α (P=0.046) and VEGF (P=0.002). So, cadmium consumption may abnormally raise cardiac HIF1-α and VEGF of pregnant rats and swimming training may balance cadmium effects and protect their hearts. 


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