TY - JOUR ID - 60980 TI - The Study of the Effect of Swimming Endurance Training and Cadmium Consumption on Cardiac Intrinsic Markers of Hypoxia and Vascular Endothelial Growth in Pregnant Rats JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - Jafari, Ahmad AU - Mirdar, Shadmehr AU - Zarvar, Mohsen AD - PhD Student of Exercise Physiology, Mazandaran University, Babolsar, Iran AD - Associate Professor, Mazandaran University, Babolsar, Iran AD - MSc of Physical Education, University of Tehran, Tehran, Iran Y1 - 2017 PY - 2017 VL - 8 IS - 4 SP - 517 EP - 531 KW - Cadmium KW - hypoxia inducible factor 1 alpha KW - swimming training KW - vascular endothelial growth factor DO - 10.22059/jsb.2017.60980 N2 -   The aim of this study was to examine the effect of swimming submaximal training and cadmium consumption on cardiac HIF1-α and vascular endothelial growth factor (VEGF) in pregnant rats. 32 pregnant Wistar rats were randomly divided into 4 groups: cadmium, swimming, cadmium+swimming and control. Experimental groups performed the swimming protocol for 3 weeks, 5 sessions a week for 60 minutes per session. The cadmium administrated by cadmium chloride dissolved in water was consumed by cadmium and cadmium+ swimming groups. The levels of cardiac HIF1-α and VEGF were analyzed by ELIZA method. The results showed that cadmium administration alone and/or with swimming significantly increased HIF1-α and VEGF (P=0.001). Swimming alone significantly decreased HIF1-α while it significantly increased VEGF (P=0.001). A combination of swimming and cadmium consumption decreased the cadmium effects on HIF1-α (P=0.046) and VEGF (P=0.002). So, cadmium consumption may abnormally raise cardiac HIF1-α and VEGF of pregnant rats and swimming training may balance cadmium effects and protect their hearts.  UR - https://jsb.ut.ac.ir/article_60980.html L1 - https://jsb.ut.ac.ir/article_60980_60dd7a77e8169a77a369f2fc7694d4ba.pdf ER -