The purpose of the present study was to determine the effect of three and five sessions on of the continuous aerobic training on high sensitive C-reactive protein (HS-CRP) in wistar 14848 rats (325.6+4.93 grams, 21.5 months old and they stopped fertility for at least 3 months). For this purpose, 56 rats were divided randomly into a control group and two experimental groups. The experimental groups, in turn, were divided into 5 and 3 sessions of continuous training groups. The experimental training programs were performed five or three days a week for 12 weeks at a definite treadmill speed. Blood samples were gathered in three phases: pre-training, mid-training and post-training following 12-14 hours of an overnight fasting. The results showed that HS-CRP levels in both 5 and 3 sessions of continuous aerobic training groups decreased insignificantly in the first 6 weeks and significantly after 12 weeks, but HS-CRP level in the control group increased significantly after 6 and 12 weeks. The research findings for HS-CRP showed significant changes in two training groups after 6 and 12 weeks when compared with the control group as well as no significant changes between 5 and 3 sessions of continuous training groups after 6 and 12 weeks. However, the difference in HS-CRP levels between the control and the experimental groups was significant after 6 and 12 weeks. These findings suggest that although the effectiveness of 6 sessions of training a week is generally more than 3 sessions of training, the training duration is more important than the number of training sessions to control systemic inflammation response.