Introduction: Alzheimer's disease (AD) is one of the neurodegenerative diseases associated with cognitive decline and inflammation. The aim of this study was to the effect of ginkgo biloba supplement and intermittent endurance training on serum TNF-α and BDNF activity in male Alzheimer's model tats.
Methods: For this purpose, 50 male Wistar rats were divided into seven control groups (n=8), Alzheimer's control group (n=8), placebo group (n=5), sham group (five heads), Alzheimer's + exercise group (n=8), Alzheimer's group + supplement (eight heads) and Alzheimer group + supplement and exercise (eight heads) were divided. Intermittent endurance training was performed for eight weeks, five days a week. The receiving animals received 100 mg/kg supplement by gavage for five days a week. The Alzheimer's model was induced by injecting beta-amyloid into both sides of the ventricles of the animals' brains. To check the results of Lon's test to check the homogeneity of the data, a one-way analysis of variance test was performed to check the difference between the groups at the significance level of P < 0.05 using SPSS22 software.
Results: The results of the one-way analysis of variance test showed that there is no significant difference between BDNF and TNF-α levels in the serum of male Alzheimer's model rats (P<0.05).
Conclusion: Considering that the levels of BDNF and TNF-α are found in the peripheral brain and nerves and play an important role in neuronal protection and neurogenesis, periodic endurance training did not affect their levels in the serum of male Alzheimer's model rats.